Disease relevance of Calycine

• The results show that members of the calycin protein family can cause IgE antibody responses by inhalation or ingestion and are associated with asthma and food hypersensitivity [1].
• One gene, however, encoding a member of the lipocalin and calycin protein families, was 12-fold overexpressed in neu mammary tumors and was not overexpressed in ras or chemically induced carcinomas [2].
• Milk of calcium in calycine diverticula [3].

High impact information on Calycine

• The overall structure of MTCP-1 superficially resembles the structures of proteins in the lipocalin family and calycin superfamily [4].
• The results also demonstrate, however, that formation of persistent and functional synapses with NM neurons throughout development is not sufficient to induce any axon to assume the calycine form of a cochlear nerve endbulb.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
• In the light microscope, aberrant axon terminals labeled in vitro with HRP appear to form boutons quite unlike the large calycine endbulbs made by the normal cochlear nerve (CN) endings in NM [5].
• Sequence similarity searches showed that Bla g 4 was a ligand binding protein or calycin and unexpectedly revealed that this family contained several important allergens: beta-lactoglobulin, from cow milk, and rat and mouse urinary proteins [1].
• Both species produce several potent allergens, including Bla g 2 (inactive aspartic proteinase), Bla g 4 (calycin), Bla g 5 (glutathione-S-transferase), the group 1 cross-reactive allergens Bla g 1 and Per a 1, and tropomyosin [6].

Chemical compound and disease context of Calycine

• The so-called Milk of Calcium Renal Cyst is a rare condition wherein calcium salts in a fine suspension are retained in a calycine diverticulum [3].

Biological context of Calycine

• Bla g 4 is a ligand-binding protein (or calycin) that causes IgE antibody responses in 40% to 60% of patients allergic to cockroaches [7].
• Sequence homology searches have identified Bla g 2 as an aspartic protease and Bla g 4 as a calycin [8].
• A novel binding site in catalase is suggested by structural similarity to the calycin superfamily [9].

Anatomical context of Calycine

• This same subcellular distribution of Kv3.1b was seen in adult, with membranes of calycine terminals more uniformly labeled [10].
• These fibers form the largest calycine endings in the cristae ampullares and also the spoon endings in the tangential vestibular nucleus of the medulla oblongata [11].
• Differences between calycine units and the type I hair cell of mammals are discussed, and evidence that suggests an equilibratory function for the lacertilian papilla neglecta is presented [12].
• Scanning electron microscopy (SEM) shows, at papillary tips bulging into the calycine space, crystal masses covered either by the epithelium or a thin fibrous veil, or by unidentified mobile cuboidal cells [13].

Gene context of Calycine

• We have previously shown that neu oncogene-initiated rat mammary carcinomas uniquely over-express neu-related lipocalin (NRL), a member of the calycin protein superfamily [14].
• A comparison is performed between SVD-generated clusters of proteins and annotation reported in the SWISS-PROT Database for a set of protein sequences forming the calycin superfamily, entailing all entries corresponding to the lipocalin, cytosolic fatty acid-binding protein, and avidin-streptavidin Prosite patterns [15].

Analytical, diagnostic and therapeutic context of Calycine

• Sequence analysis indicated that Lma-p18 belongs to the calycin superfamily and is very similar to Lma-p22, the first known male-specific tergal protein in L. maderae [16].

References