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Chemical Compound Review

Calycine     (3E)-3-(5-hydroxy-3-oxo-4- phenyl-2...

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Disease relevance of Calycine


High impact information on Calycine

  • The overall structure of MTCP-1 superficially resembles the structures of proteins in the lipocalin family and calycin superfamily [4].
  • The results also demonstrate, however, that formation of persistent and functional synapses with NM neurons throughout development is not sufficient to induce any axon to assume the calycine form of a cochlear nerve endbulb.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
  • In the light microscope, aberrant axon terminals labeled in vitro with HRP appear to form boutons quite unlike the large calycine endbulbs made by the normal cochlear nerve (CN) endings in NM [5].
  • Sequence similarity searches showed that Bla g 4 was a ligand binding protein or calycin and unexpectedly revealed that this family contained several important allergens: beta-lactoglobulin, from cow milk, and rat and mouse urinary proteins [1].
  • Both species produce several potent allergens, including Bla g 2 (inactive aspartic proteinase), Bla g 4 (calycin), Bla g 5 (glutathione-S-transferase), the group 1 cross-reactive allergens Bla g 1 and Per a 1, and tropomyosin [6].

Chemical compound and disease context of Calycine


Biological context of Calycine


Anatomical context of Calycine

  • This same subcellular distribution of Kv3.1b was seen in adult, with membranes of calycine terminals more uniformly labeled [10].
  • These fibers form the largest calycine endings in the cristae ampullares and also the spoon endings in the tangential vestibular nucleus of the medulla oblongata [11].
  • Differences between calycine units and the type I hair cell of mammals are discussed, and evidence that suggests an equilibratory function for the lacertilian papilla neglecta is presented [12].
  • Scanning electron microscopy (SEM) shows, at papillary tips bulging into the calycine space, crystal masses covered either by the epithelium or a thin fibrous veil, or by unidentified mobile cuboidal cells [13].

Gene context of Calycine

  • We have previously shown that neu oncogene-initiated rat mammary carcinomas uniquely over-express neu-related lipocalin (NRL), a member of the calycin protein superfamily [14].
  • A comparison is performed between SVD-generated clusters of proteins and annotation reported in the SWISS-PROT Database for a set of protein sequences forming the calycin superfamily, entailing all entries corresponding to the lipocalin, cytosolic fatty acid-binding protein, and avidin-streptavidin Prosite patterns [15].

Analytical, diagnostic and therapeutic context of Calycine

  • Sequence analysis indicated that Lma-p18 belongs to the calycin superfamily and is very similar to Lma-p22, the first known male-specific tergal protein in L. maderae [16].


  1. Cloning of cockroach allergen, Bla g 4, identifies ligand binding proteins (or calycins) as a cause of IgE antibody responses. Arruda, L.K., Vailes, L.D., Hayden, M.L., Benjamin, D.C., Chapman, M.D. J. Biol. Chem. (1995) [Pubmed]
  2. Overexpression of neu-related lipocalin (NRL) in neu-initiated but not ras or chemically initiated rat mammary carcinomas. Stoesz, S.P., Gould, M.N. Oncogene (1995) [Pubmed]
  3. Milk of calcium in calycine diverticula. Healey, T., Way, B.G., Grundy, W.R. The British journal of radiology. (1980) [Pubmed]
  4. Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. Fu, Z.Q., Du Bois, G.C., Song, S.P., Kulikovskaya, I., Virgilio, L., Rothstein, J.L., Croce, C.M., Weber, I.T., Harrison, R.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Adaptations of synaptic form in an aberrant projection to the avian cochlear nucleus. Parks, T.N., Taylor, D.A., Jackson, H. J. Neurosci. (1990) [Pubmed]
  6. Cockroach allergens and asthma. Arruda, L.K., Vailes, L.D., Ferriani, V.P., Santos, A.B., Pomés, A., Chapman, M.D. J. Allergy Clin. Immunol. (2001) [Pubmed]
  7. High-level expression of cockroach allergen, Bla g 4, in Pichia pastoris. Vailes, L.D., Kinter, M.T., Arruda, L.K., Chapman, M.D. J. Allergy Clin. Immunol. (1998) [Pubmed]
  8. Molecular cloning of German cockroach (Blattella germanica) allergens. Arruda, L.K., Vailes, L.D., Benjamin, D.C., Chapman, M.D. Int. Arch. Allergy Immunol. (1995) [Pubmed]
  9. A novel binding site in catalase is suggested by structural similarity to the calycin superfamily. Russell, R.B., Sternberg, M.J. Protein Eng. (1996) [Pubmed]
  10. Subcellular localization of the voltage-dependent potassium channel Kv3.1b in postnatal and adult rat medial nucleus of the trapezoid body. Elezgarai, I., Díez, J., Puente, N., Azkue, J.J., Benítez, R., Bilbao, A., Knöpfel, T., Doñate-Oliver, F., Grandes, P. Neuroscience (2003) [Pubmed]
  11. Ultrastructural study of calycine synaptic endings of colossal vestibular fibers in the cristae ampullares of the developing chick. Peusner, K.D., Lindberg, N.H., Mansfield, P.F. Int. J. Dev. Neurosci. (1988) [Pubmed]
  12. A study of the structure of the papilla neglecta in the lizard, Anolis carolinensis. Baird, I.L., Lowman, G.F. Anat. Rec. (1978) [Pubmed]
  13. Etiology of calcium oxalate nephrolithiasis in rats. II. The role of the papilla in stone formation. de Bruijn, W.C., Boevé, E.R., van Run, P.R., van Miert, P.P., de Water, R., Romijn, J.C., Verkoelen, C.F., Cao, L.C., van 't Noordende, J.M., Schrder, F.H. Scanning Microsc. (1995) [Pubmed]
  14. Heterogeneous expression of the lipocalin NGAL in primary breast cancers. Stoesz, S.P., Friedl, A., Haag, J.D., Lindstrom, M.J., Clark, G.M., Gould, M.N. Int. J. Cancer (1998) [Pubmed]
  15. Singular value decomposition analysis of protein sequence alignment score data. Fogolari, F., Tessari, S., Molinari, H. Proteins (2002) [Pubmed]
  16. Molecular characterization of a new adult male putative calycin specific to tergal aphrodisiac secretion in the cockroach Leucophaea maderae. Cornette, R., Farine, J.P., Quennedey, B., Brossut, R. FEBS Lett. (2001) [Pubmed]
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