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Gene Review

MTCP1  -  mature T-cell proliferation 1

Homo sapiens

Synonyms: C6.1B, MTCP-1 type B1, Mature T-cell proliferation-1 type B1, P13MTCP1, Protein p13 MTCP-1, ...
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Disease relevance of MTCP1


High impact information on MTCP1


Chemical compound and disease context of MTCP1

  • MTCPP bound to the HIV-1 envelope glycoprotein gp120 and to full-length V3 loop peptides corresponding to several HIV-1 isolates but not to other peptides from gp120 + gp41 [9].

Biological context of MTCP1


Anatomical context of MTCP1


Associations of MTCP1 with chemical compounds

  • The three-dimensional solution structure of the human p8MTCP1 protein encoded by the MTCP1 oncogene has been previously determined by homonuclear proton two-dimensional NMR methods at 600 MHz: it consists of an original scaffold comprising three alpha-helices, associated with a new cysteine motif [17].
  • The MTCP-1 crystals grown from 1.5 M ammonium sulfate diffracted to only 3.0 A resolution with some disorder in the diffraction [18].

Other interactions of MTCP1

  • This association is functional, as the presence of TCL1 but not MTCP1 or TCL1b increased Akt3 kinase activity in in vitro kinase assays [19].
  • This is the first time that TCRB has been implicated in MTCP1 B1 activation [14].

Analytical, diagnostic and therapeutic context of MTCP1


  1. Transgenic mice for MTCP1 develop T-cell prolymphocytic leukemia. Gritti, C., Dastot, H., Soulier, J., Janin, A., Daniel, M.T., Madani, A., Grimber, G., Briand, P., Sigaux, F., Stern, M.H. Blood (1998) [Pubmed]
  2. Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations. Madani, A., Choukroun, V., Soulier, J., Cacheux, V., Claisse, J.F., Valensi, F., Daliphard, S., Cazin, B., Levy, V., Leblond, V., Daniel, M.T., Sigaux, F., Stern, M.H. Blood (1996) [Pubmed]
  3. Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients. Thick, J., Metcalfe, J.A., Mak, Y.F., Beatty, D., Minegishi, M., Dyer, M.J., Lucas, G., Taylor, A.M. Oncogene (1996) [Pubmed]
  4. TCL-1, MTCP-1 and TML-1 gene expression profile in non-leukemic clonal proliferations associated with ataxia-telangiectasia. Chun, H.H., Castellví-Bel, S., Wang, Z., Nagourney, R.A., Plaeger, S., Becker-Catania, S.G., Naeim, F., Sparkes, R.S., Gatti, R.A. Int. J. Cancer (2002) [Pubmed]
  5. Molecular analysis of the mature T cell proliferation-1 (MTCP-1) gene in Xq28-linked incontinentia pigmenti. Woffendin, H., Esposito, T., Jakins, T., Bardaro, T., Stern, M.H., Kenwrick, S. Eur. J. Hum. Genet. (2000) [Pubmed]
  6. The protooncogene TCL1 is an Akt kinase coactivator. Laine, J., Künstle, G., Obata, T., Sha, M., Noguchi, M. Mol. Cell (2000) [Pubmed]
  7. Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. Fu, Z.Q., Du Bois, G.C., Song, S.P., Kulikovskaya, I., Virgilio, L., Rothstein, J.L., Croce, C.M., Weber, I.T., Harrison, R.W. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1. Künstle, G., Laine, J., Pierron, G., Kagami Si, S., Nakajima, H., Hoh, F., Roumestand, C., Stern, M.H., Noguchi, M. Mol. Cell. Biol. (2002) [Pubmed]
  9. Structural requirements for and consequences of an antiviral porphyrin binding to the V3 loop of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp120. Neurath, A.R., Strick, N., Debnath, A.K. J. Mol. Recognit. (1995) [Pubmed]
  10. Expression and stabilization of the MCT-1 protein by DNA damaging agents. Herbert, G.B., Shi, B., Gartenhaus, R.B. Oncogene (2001) [Pubmed]
  11. Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations. Gritti, C., Choukroun, V., Soulier, J., Madani, A., Dastot, H., Leblond, V., Radford-Weiss, I., Valensi, F., Varet, B., Sigaux, F., Stern, M.H. Oncogene (1997) [Pubmed]
  12. Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data. Guignard, L., Padilla, A., Mispelter, J., Yang, Y.S., Stern, M.H., Lhoste, J.M., Roumestand, C. J. Biomol. NMR (2000) [Pubmed]
  13. Solution structure of the recombinant human oncoprotein p13MTCP1. Yang, Y.S., Guignard, L., Padilla, A., Hoh, F., Strub, M.P., Stern, M.H., Lhoste, J.M., Roumestand, C. J. Biomol. NMR (1998) [Pubmed]
  14. T-cell prolymphocytic leukaemia: antigen receptor gene rearrangement and a novel mode of MTCP1 B1 activation. De Schouwer, P.J., Dyer, M.J., Brito-Babapulle, V.B., Matutes, E., Catovsky, D., Yuille, M.R. Br. J. Haematol. (2000) [Pubmed]
  15. The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation. Soulier, J., Madani, A., Cacheux, V., Rosenzwajg, M., Sigaux, F., Stern, M.H. Oncogene (1994) [Pubmed]
  16. Biochemical markers evaluation of RAW transformed cells during treatment with various biomaterials. Johnston, W., Carr, S., Benghuzzi, H., Tucci, M., Puckett, A., Tsao, A., Hughes, J. Biomedical sciences instrumentation. (1999) [Pubmed]
  17. Refined solution structure and backbone dynamics of 15N-labeled C12A-p8MTCP1 studied by NMR relaxation. Barthe, P., Chiche, L., Declerck, N., Delsuc, M.A., Lefèvre, J.F., Malliavin, T., Mispelter, J., Stern, M.H., Lhoste, J.M., Roumestand, C. J. Biomol. NMR (1999) [Pubmed]
  18. Improving the diffraction quality of MTCP-1 crystals by post-crystallization soaking. Fu, Z.Q., Du Bois, G.C., Song, S.P., Harrison, R.W., Weber, I.T. Acta Crystallogr. D Biol. Crystallogr. (1999) [Pubmed]
  19. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. Laine, J., Künstle, G., Obata, T., Noguchi, M. J. Biol. Chem. (2002) [Pubmed]
  20. Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins. Du Bois, G.C., Song, S.P., Kulikovskaya, I., Virgilio, L., Varnum, J., Germann, M.W., Croce, C.M. Protein Expr. Purif. (1998) [Pubmed]
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