The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Diverticulum

  • Targeted projections, made up of a limited number of coronal source images, showed diverticula and smaller polyps more clearly [1].
  • In 11 patients abnormalities were diagnosed on the basis of iohexol esophagograms; the abnormalities included extraluminal extravasation of contrast material (n = 7), aspiration (n = 1), esophageal stricture with intramural diverticulosis (n = 1), edema of the gastroesophageal junction (n = 1), and epiphrenic diverticulum (n = 1) [2].
  • Serum samples from 84 benign colorectal disease cases were examined; of these, 0 of 28 (0%) colorectal adenoma, 1 of 39 (3%) ulcerative proctocolitis, 0 of 15 (0%) diverticulosis, and 0 of 2 (0%) irritable bowel disease sera contained more than 10 mu/ml CA 72 [3].
  • In conclusion patients with spinal meningeal diverticula (frequently seen in Marfan's syndrome) might be at increased risk of developing CSF leaks, possibly secondary to Valsalva maneuver or minor unrecognized trauma [4].
  • This article describes the clinical and morphologic features of this unusual case, reviews the topic of neoplasms involving hernia sacs and Meckel's diverticula, and includes a brief review of immunocytochemical findings in carcinoid tumors [5].

Psychiatry related information on Diverticulum


High impact information on Diverticulum


Chemical compound and disease context of Diverticulum


Biological context of Diverticulum

  • This line, HBC-3, stains positively for alpha-fetoprotein, albumin, and cytokeratin 14 (CK-14), protein markers expressed by the embryonic liver diverticulum, indicating that HBC-3 cells retain an undifferentiated hepatoblast phenotype [17].
  • Reporter gene expression analyses also revealed several previously unknown sites of Nkx3.1 expression in males, including urethral glands, glandular cells in the urethral diverticulum and basal epithelial cells in the prostate [18].
  • STUDY DESIGN/MATERIAL AND METHODS: Between 1976 and 1993, 109 patients with a hypopharyngeal diverticulum were operated on at the Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, either transcutaneously combined with a cricopharyngeal myotomy (n = 76), or microendoscopically (n = 37) using the CO2 laser [19].
  • Digestive cells ensure intracellular digestion of nutrients absorbed by pinocytosis and store glycogen, lipids and mineral salts; the wastes of the digestive process (guanine, uric acid, mineral elements, pigments) are concentrated in "brown body vacuoles" which are ejected into the lumen of the diverticula [20].
  • A disappearance of apoptotic cells was associated with strong Bcl-2 expression in the foregut diverticulum at 10.5 and 11.5 days of gestation [21].

Anatomical context of Diverticulum


Gene context of Diverticulum

  • In situ hybridization studies of staged specific embryos demonstrate that HNF-6 and its potential target gene, HNF-3 beta, are coexpressed in the pancreatic and hepatic diverticulum [27].
  • T/ebp/Nkx2.1 haploinsufficiency causes abnormal fusion of the UBB with the thyroid diverticulum, which stays as a cluster of C-cells around the vesicular structure, similar to the one observed in mice null for T/ebp/Nkx2.1 expression [24].
  • In particular, in the region of the foregut that gives rise to the liver, Hex expression is nuclear in the endodermal cells of the hepatic diverticulum, whereas expression is primarily cytoplasmic in cells lateral to the liver-forming region [28].
  • In humans, AFP is expressed in the hepatic diverticulum at 26 d postovulation as it differentiates from the foregut endoderm (i.e. in the most primitive hepatocytes) [29].
  • Right atrial diverticulum and hypertrophic cardiomyopathy [30].

Analytical, diagnostic and therapeutic context of Diverticulum


  1. Preliminary assessment of three-dimensional magnetic resonance imaging for various colonic disorders. Luboldt, W., Bauerfeind, P., Steiner, P., Fried, M., Krestin, G.P., Debatin, J.F. Lancet (1997) [Pubmed]
  2. Esophageal disruption: evaluation with iohexol esophagography. Brick, S.H., Caroline, D.F., Lev-Toaff, A.S., Friedman, A.C., Grumbach, K., Radecki, P.D. Radiology. (1988) [Pubmed]
  3. Monoclonal antibody immunoradiometric assay for an antigenic determinant (CA 72) on a novel pancarcinoma antigen (TAG-72). Klug, T.L., Sattler, M.A., Colcher, D., Schlom, J. Int. J. Cancer (1986) [Pubmed]
  4. Postural headache in a patient with Marfan's syndrome. Ferrante, E., Citterio, A., Savino, A., Santalucia, P. Cephalalgia : an international journal of headache. (2003) [Pubmed]
  5. Dual carcinoid tumors of Meckel's diverticulum presenting as metastasis in an inguinal hernia sac: case report with literature review. Dixon, A.Y., McAnaw, M., McGregor, D.H., Keushkerian, S., Miller, L.K., Pierce, P.D. Am. J. Gastroenterol. (1988) [Pubmed]
  6. Urethral diverticulum presenting with chronic pelvic pain: a case report. Juang, C.M., Wang, P.H., Yu, K.J., Yuan, C.C., Ng, H.T. Zhonghua Yi Xue Za Zhi (Taipei) (1999) [Pubmed]
  7. Sonic hedgehog is essential to foregut development. Litingtung, Y., Lei, L., Westphal, H., Chiang, C. Nat. Genet. (1998) [Pubmed]
  8. Insulin-promoter-factor 1 is required for pancreas development in mice. Jonsson, J., Carlsson, L., Edlund, T., Edlund, H. Nature (1994) [Pubmed]
  9. Spinal meningeal diverticula in autosomal dominant polycystic kidney disease. Schievink, W.I., Torres, V.E. Lancet (1997) [Pubmed]
  10. Role of intestinal bacterial overgrowth in ethanol production and metabolism in rats. Baraona, E., Julkunen, R., Tannenbaum, L., Lieber, C.S. Gastroenterology (1986) [Pubmed]
  11. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Duncan, S.A., Manova, K., Chen, W.S., Hoodless, P., Weinstein, D.C., Bachvarova, R.F., Darnell, J.E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  12. Short chain fatty acid distributions of enema samples from a sigmoidoscopy population: an association of high acetate and low butyrate ratios with adenomatous polyps and colon cancer. Weaver, G.A., Krause, J.A., Miller, T.L., Wolin, M.J. Gut (1988) [Pubmed]
  13. Diverticular disease: imaging with post-double-contrast sigmoid flush. Lappas, J.C., Maglinte, D.D., Kopecky, K.K., Cockerill, E.M., Lehman, G.A. Radiology. (1988) [Pubmed]
  14. Hyperechoic foci in the gallbladder wall as a sign of microabscess formation or diverticula. Graif, M., Horovitz, A., Itzchak, Y., Strauss, S. Radiology. (1984) [Pubmed]
  15. Pitfalls in technetium-99m HIDA biliary imaging: duodenal diverticulum simulating the gallbladder. Brown, J.F., Buchanan, J.W., Wagner, H.N. J. Nucl. Med. (1981) [Pubmed]
  16. Immunohistochemical detection of telomerase reverse transcriptase in colorectal adenocarcinoma and benign colonic mucosa. Wei, R., Younes, M. Hum. Pathol. (2002) [Pubmed]
  17. Selective bipotential differentiation of mouse embryonic hepatoblasts in vitro. Rogler, L.E. Am. J. Pathol. (1997) [Pubmed]
  18. Distinct regulatory elements mediate the dynamic expression pattern of Nkx3.1. Chen, H., Mutton, L.N., Prins, G.S., Bieberich, C.J. Dev. Dyn. (2005) [Pubmed]
  19. Microendoscopic treatment of the hypopharyngeal diverticulum with the CO2 laser. Lippert, B.M., Folz, B.J., Gottschlich, S., Werner, J.A. Lasers in surgery and medicine. (1997) [Pubmed]
  20. Cytophysiological aspects of digestion and storage in the liver of a scorpion, Androctonus australis (Arachnida). Goyffon, M., Martoja, R. Cell Tissue Res. (1983) [Pubmed]
  21. Apoptosis in normal rat embryo tissues during early organogenesis: the possible involvement of Bax and Bcl-2. Sun, F., Akazawa, S., Sugahara, K., Kamihira, S., Kawasaki, E., Eguchi, K., Koji, T. Arch. Histol. Cytol. (2002) [Pubmed]
  22. Distal fallopian tube occlusion: false diagnosis with hysterosalpingography in cases of tubal diverticula. Muzii, L., Marana, R., Mancuso, S. Radiology. (1996) [Pubmed]
  23. Protective factors in posterior urethral valves. Rittenberg, M.H., Hulbert, W.C., Snyder, H.M., Duckett, J.W. J. Urol. (1988) [Pubmed]
  24. Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid. Kusakabe, T., Hoshi, N., Kimura, S. Dev. Dyn. (2006) [Pubmed]
  25. Mucin histochemistry of heterotopic gastric mucosa of the upper esophagus in adults: possible pathogenic implications. Bogomoletz, W.V., Geboes, K., Feydy, P., Nasca, S., Ectors, N., Rigaud, C. Hum. Pathol. (1988) [Pubmed]
  26. Congenital diverticulum of the right ventricle with ventricular septal defect. Terai, M., Nakanishi, T., Momma, K., Ohta, F., Imai, Y., Takao, A., Ando, M., Minami, Y., Satomi, G. Am. Heart J. (1985) [Pubmed]
  27. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. Rausa, F., Samadani, U., Ye, H., Lim, L., Fletcher, C.F., Jenkins, N.A., Copeland, N.G., Costa, R.H. Dev. Biol. (1997) [Pubmed]
  28. Immunocytochemical characterization of murine Hex, a homeobox-containing protein. Ghosh, B., Ganea, G.R., Denson, L.A., Iannucci, R., Jacobs, H.C., Bogue, C.W. Pediatr. Res. (2000) [Pubmed]
  29. Differences between human and mouse alpha-fetoprotein expression during early development. Jones, E.A., Clement-Jones, M., James, O.F., Wilson, D.I. J. Anat. (2001) [Pubmed]
  30. Right atrial diverticulum and hypertrophic cardiomyopathy. Vilacosta, I., San Román, J.A., Camino, A., Zamorano, J., Javier Cortés, F., Sánchez Harguindey, L. Eur. Heart J. (1993) [Pubmed]
  31. Laparoscopic management of caliceal diverticular calculi. Miller, S.D., Ng, C.S., Streem, S.B., Gill, I.S. J. Urol. (2002) [Pubmed]
  32. Role of aztreonam in urinary tract infections. Roberts, J.A. Urology (1988) [Pubmed]
  33. An analysis of the relationship between bile duct stones and periampullary duodenal diverticula. Chandy, G., Hart, W.J., Roberts-Thomson, I.C. J. Gastroenterol. Hepatol. (1997) [Pubmed]
  34. Intralesional administration of formalin for treatment of epidermal inclusion cysts in five horses. Frankeny, R.L. J. Am. Vet. Med. Assoc. (2003) [Pubmed]
  35. Intraoperative catheter management during laparoscopic excision of a giant bladder diverticulum. Khonsari, S., Lee, D.I., Basillote, J.B., McDougall, E.M., Clayman, R.V. Journal of laparoendoscopic & advanced surgical techniques. Part A. (2004) [Pubmed]
WikiGenes - Universities