The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Enniatin     (3S,9S,15S)-4,10,16- trimethyl-3,6,9,12,15...

Synonyms: Fusafungin, Fusafungime, Fusafungina, Fusafungine, Fusafunginum, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Enniatin

  • The mode of Pdr5p inhibition of enniatin was competitive against FK506, and its inhibitory activity was more potent with less toxicity than that of FK506 [1].

High impact information on Enniatin


Biological context of Enniatin


Anatomical context of Enniatin

  • The MRC-5 cell line in combination with the BrdU assay resulted in the lowest inhibitory concentrations (IC(50)) for exposure with enniatins in the range 0.8 microM (enniatin A) to 3.6 microM (enniatin B) [10].

Associations of Enniatin with other chemical compounds


Gene context of Enniatin

  • LC-MS conditions for enniatin analyses by API electrospray technique were set up, this allowing a unique identification of three different enniatins [11].

Analytical, diagnostic and therapeutic context of Enniatin

  • To find out whether enniatin synthesis is an intramolecular process or the result of three interacting Esyn molecules (intermolecular), analytical ultracentrifugation equilibration studies were carried out [15].


  1. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga, K., Yamamoto, S., Fukuda, H., Hamanaka, N., Oda, K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described. Lawen, A., Zocher, R. J. Biol. Chem. (1990) [Pubmed]
  3. Enniatin Exerts p53-Dependent Cytostatic and p53-Independent Cytotoxic Activities against Human Cancer Cells. Dornetshuber, R., Heffeter, P., Kamyar, M.R., Peterbauer, T., Berger, W., Lemmens-Gruber, R. Chem. Res. Toxicol. (2007) [Pubmed]
  4. Effect of disruption of the enniatin synthetase gene on the virulence of Fusarium avenaceum. Herrmann, M., Zocher, R., Haese, A. Mol. Plant Microbe Interact. (1996) [Pubmed]
  5. A new function of isonitrile as an inhibitor of the Pdr5p multidrug ABC transporter in Saccharomyces cerevisiae. Yamamoto, S., Hiraga, K., Abiko, A., Hamanaka, N., Oda, K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  6. Investigation of the electrophysiological properties of enniatins. Kamyar, M., Rawnduzi, P., Studenik, C.R., Kouri, K., Lemmens-Gruber, R. Arch. Biochem. Biophys. (2004) [Pubmed]
  7. Arrangement of catalytic sites in the multifunctional enzyme enniatin synthetase. Pieper, R., Haese, A., Schröder, W., Zocher, R. Eur. J. Biochem. (1995) [Pubmed]
  8. Alkali ion transport through lipid bilayer membranes mediated by enniatin A and B and beauvericin. Benz, R. J. Membr. Biol. (1978) [Pubmed]
  9. Highly conserved N-methyltransferases as an integral part of peptide synthetases. Burmester, J., Haese, A., Zocher, R. Biochem. Mol. Biol. Int. (1995) [Pubmed]
  10. Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum. Ivanova, L., Skjerve, E., Eriksen, G.S., Uhlig, S. Toxicon (2006) [Pubmed]
  11. Simultaneous determination of beauvericin, enniatins, and fusaproliferin by high performance liquid chromatography. Monti, S.M., Fogliano, V., Logrieco, A., Ferracane, R., Ritieni, A. J. Agric. Food Chem. (2000) [Pubmed]
  12. Enniatin production by Fusarium sambucinum: primary, secondary, and unitary metabolism. Audhya, T.K., Russell, D.W. J. Gen. Microbiol. (1975) [Pubmed]
  13. Kinetics of L-[14C]leucine transport in Saccharomyces cerevisiae: effect of energy coupling inhibitors. Ramos, E.H., de Bongioanni, L.C., Stoppani, A.O. Biochim. Biophys. Acta (1980) [Pubmed]
  14. Effects of moniliformin in presence of cyclohexadepsipeptides on isolated mammalian tissue and cells. Kamyar, M.R., Kouri, K., Rawnduzi, P., Studenik, C., Lemmens-Gruber, R. Toxicology in vitro : an international journal published in association with BIBRA. (2006) [Pubmed]
  15. Enniatin synthetase is a monomer with extended structure: evidence for an intramolecular reaction mechanism. Glinski, M., Urbanke, C., Hornbogen, T., Zocher, R. Arch. Microbiol. (2002) [Pubmed]
WikiGenes - Universities