Disease relevance of Emtryl

• We investigated the metabolism of dimetridazole (1,2-dimethyl-5-nitroimidazole) (DMZ) by the resting cell method in a susceptible strain of Bacteroides fragilis and in the same strain containing the nimA gene, which conferred resistance to 5-nitroimidazole drugs [1].
• Both DiacDMH and AcDMH were examined for bactericidal activity against such strains as Bacteroides fragilis, Clostridium perfringens, and Escherichia coli strain SR58, which are known to be sensitive to dimetridazole, as well as a variety of other bacteria [2].
• Sensitivity to dimetridazole of field isolates of Treponema hyodysenteriae [3].
• Thirteen affected calves were treated orally with dimetridazole (50 mg/kg of body weight, daily, for 5 days), with complete resolution of the diarrhea and elimination of the Giardia [4].
• Toxicity of dimetridazole in waterfowl [5].

High impact information on Emtryl

• A method was developed for the determination of the nitroimidazole compounds dimetridazole (DMZ), ronidazole (RNZ) and metronidazole (MNZ) by gas chromatography with nitrogen phosphorus detection [6].
• Evaluation of the genotoxic activity of metronidazole and dimetridazole in human lymphocytes by the comet assay [7].
• After laying hens had been dosed orally with dimetridazole (DMZ) for 3 days (50 and 250 mg/kg body weight (b.w.)) or intramuscularly, also for 3 days (50 mg/kg b.w.), the residues were determined in serum, liver, breast and thigh muscle by liquid chromatography [8].
• The minimal inhibitory concentrations of carbadox, dimetridazole, lincomycin, ronidazole, and tiamulin against isolates of Treponema hyodysenteriae and Treponema innocens were determined by an agar-dilution method [9].
• The anti-trichomonal efficacy and pharmacokinetics of dimetridazole were investigated in the homing pigeon (Columba livia) [10].

Chemical compound and disease context of Emtryl

• Ipronidazole, ronidazole, and dimetridazole in feed for treatment and prevention of swine dysentery in swine after multiple exposure and in swine spontaneously infected with Salmonella choleraesuis [11].

Biological context of Emtryl

• A reduction in water intake was only noted with mice receiving 10 mg/ml dimetridazole [12].

Associations of Emtryl with other chemical compounds

• The genotoxicity of metronidazole (MZ) and dimetridazole (DZ) has been evaluated in human lymphocytes using the comet assay [7].
• Extracts from 4 types of swine feed containing 0.11 ppm each of dimetridazole (DMZ) and ipronidazole (IPR) were analyzed by capillary gas chromatography/mass spectrometry (GC/MS) using multiple ion detection (MID) techniques [13].
• The use of metronidazole, tinidazole and dimetridazole in eliminating trichomonads from laboratory mice [12].

Analytical, diagnostic and therapeutic context of Emtryl

• Determination of dimetridazole in pig and poultry feeds by high-performance liquid chromatography [14].
• The minimum inhibitory concentration (MIC) of dimetridazole (DMZ) against Treponema hyodysenteriae (55 isolates) obtained over the period 1974-77 from individual pigs with swine dysentery from 41 herds where DMZ had been in use was determined [15].
• Residues of dimetridazole in eggs after treatment of laying hens [16].
• They resisted 0.12% dimetridazole, low temperature (-196 degrees C), low pH (2.2), high osmotic pressure (distilled water and 30% 'Ficoll'), centrifugation (1500 g/20 min) and desiccation (room temperature for 14 days) [17].

References