Disease relevance of FLOCTAFENIN

• Floctafenine and coma in cirrhosis [1].
• When comparing the results of these trials, it appears that in the GIMEMA group the capability of offering effective treatment to elderly patients with ANLL has continuously improved and that IDARAC plus Mitoxantrone is so far the most active and best tolerated regimen [2].
• Acetaminophen 375 mg and floctafenine 50 mg induced a marked flare of urticaria/angioedema in a single-blind, placebo-controlled challenge [3].
• Granulomatous interstitial nephritis after floctafenin [4].
• A controlled trial of the analgesic effects of Floctafenine against placebo in osteoarthrosis [5].

High impact information on FLOCTAFENIN

• 3. When injected into the cerebral ventricles, floctafenine was feebly antipyretic, and then only at a dose ten times the antipyretic dose of indomethacin [6].
• Effects of intracerebroventricular floctafenine and indomethacin on body temperature in febrile rabbits [6].
• The study also indicates that floctafenine, a relatively weak cyclooxygenase inhibitor, can be a valid alternative for many patients who react adversely to other nonsteroidal anti-inflammatory drugs [7].
• The pharmacokinetics of floctafenin has been studied in man, mice, rats, and dogs at pharmacological doses [8].
• All compounds tested were found to exhibit anti-inflammatory and analgesic activities and some were more potent than the references, floctafenine and indomethacin, in carragenan-induced rat's paw edema [9].

Chemical compound and disease context of FLOCTAFENIN

• The results indicate that in the treatment of osteoarthrosis, floctafenine is comparable to ibuprofen (in the dose used in the study) in terms of efficacy and toxicity [10].

Biological context of FLOCTAFENIN

• A double-blind comparative clinical trial of floctafenine and four other analgesics conducted in general practice [11].

Anatomical context of FLOCTAFENIN

• A consistant but slight decrease in both haemoglobin and red-blood-cell count under floctafenine and ASA was found to be statistically but not clinically significant [12].
• A multicenter, double-blind, cross-over, random-order study compared the efficacy of floctafenin, 800 mg/day and acetaminophen, 3000 mg/day, in providing pain relief to 192 patients with chronic pain due to osteoarthritis in the lower limbs [13].

Associations of FLOCTAFENIN with other chemical compounds

• A high-performance liquid chromatography (HPLC) assay has been developed for the determination of glafenine and floctafenine in plasma [14].

Gene context of FLOCTAFENIN

• A double-blind controlled cross-over trial comparing floctafenine 1.6 g daily with soluble aspirin 4.0 g daily and matching placebo, in 48 patients suffering from rheumatoid arthritis, is reported [15].

Analytical, diagnostic and therapeutic context of FLOCTAFENIN

• Analgesic activity of floctafenine after cholecystectomy [16].
• 1. We injected the potent prostaglandin synthesis inhibitors, floctafenine and indomethacin, intravenously and intracerebroventricularly in rabbits made febrile by intravenous injection of leucocyte pyrogen [6].
• Simultaneous plasma determination of floctafenin and its major metabolites by high-performance liquid chromatography: preliminary observations in children [17].
• Simultaneous HPLC determination of floctafenine and its main metabolites [18].
• A double-blind crossover study comparing floctafenine 200 mg, a new analgesic drug, and dihydrocodeine 60 mg, was performed on 72 patients suffering from post-operative pain [19].

References