The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

HHSiD     cyclohexyl-hydroxy-phenyl-[3- (1...

Synonyms: Hhsi-difenidol, GNF-Pf-5565, Bio-0768, AG-K-15151, C20H33NOSi, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of hexahydrosiladifenidol


High impact information on hexahydrosiladifenidol

  • The apparent dissociation constant values were as follows: atropine (nonselective), 1.95 +/- 0.28 nmol/L; pirenzepine (M1), 169 +/- 24 nmol/L; AF-DX 116 (M2), 1542 +/- 33 nmol/L; and hexahydrosiladifenidol (M3), 29 +/- 3.4 nmol/L [2].
  • Therefore, this study was performed to characterize muscarinic receptors on rat gastric parietal cells using the 3 subtype-selective antagonists hexahydrosiladifenidol and silahexocyclium, which have high affinity for glandular M3 subtypes, and AF-DX 116, which has high affinity to cardiac M2 receptors [3].
  • To further characterize the population of the smooth muscle receptors recognized as glandular type, we performed protection experiments with hexahydrosiladifenidol, which binds to glandular M3 receptors with high affinity [4].
  • AF-DX116 (M2 selective) bound with high affinity to approximately 83% of muscarinic binding sites, and 4-DAMP and HHSiD (M3 antagonists) bound with high affinity to approximately 24 and 28% of muscarinic binding sites, respectively [5].
  • The muscarinic antagonists, hexahydrosiladifenidol and pirenzepine, inhibited carbachol-induced phosphatidylethanol formation in a concentration-dependent manner and the inhibitory constants indicated that muscarinic M1 receptors are responsible for the major part of the phospholipase D activation [6].

Anatomical context of hexahydrosiladifenidol


Associations of hexahydrosiladifenidol with other chemical compounds


Analytical, diagnostic and therapeutic context of hexahydrosiladifenidol

  • The increase in perfusion pressure upon nerve stimulation was reduced by atropine (0.01 mumol/l) or hexahydrosiladifenidol (0.1 mumol/l) to approximately 50% and increased by about 50% in the presence of AF-DX 116 (0.1 mumol/l) [9].


  1. Mini-pig urinary bladder function: comparisons of in vitro anticholinergic responses and in vivo cystometry with drugs indicated for urinary incontinence. Peterson, J.S., Patton, A.J., Noronha-Blob, L. Journal of autonomic pharmacology. (1990) [Pubmed]
  2. The muscarinic receptor gene expressed in rabbit parietal cells is the m3 subtype. Kajimura, M., Reuben, M.A., Sachs, G. Gastroenterology (1992) [Pubmed]
  3. Muscarinic receptors mediating acid secretion in isolated rat gastric parietal cells are of M3 type. Pfeiffer, A., Rochlitz, H., Noelke, B., Tacke, R., Moser, U., Mutschler, E., Lambrecht, G. Gastroenterology (1990) [Pubmed]
  4. Characterization of muscarinic receptors in guinea pig ileum longitudinal smooth muscle. Giraldo, E., Viganò, M.A., Hammer, R., Ladinsky, H. Mol. Pharmacol. (1988) [Pubmed]
  5. A minority of muscarinic receptors mediate rabbit tracheal smooth muscle contraction. Mahesh, V.K., Nunan, L.M., Halonen, M., Yamamura, H.I., Palmer, J.D., Bloom, J.W. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  6. Characterization of phospholipase D activation by muscarinic receptors in human neuroblastoma SH-SY5Y cells. Boyano-Adánez, M.C., Lundqvist, C., Larsson, C., Gustavsson, L. Neuropharmacology (1997) [Pubmed]
  7. Pharmacological characterization of the muscarinic receptor subtype mediating contraction of human peripheral airways. Watson, N., Magnussen, H., Rabe, K.F. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  8. Organ selectivity of hexahydrosiladifenidol in blocking pre- and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart. Fuder, H., Kilbinger, H., Müller, H. Eur. J. Pharmacol. (1985) [Pubmed]
  9. Different muscarinic receptors mediate autoinhibition of acetylcholine release and vagally-induced vasoconstriction in the rat isolated perfused heart. Bognar, I.T., Beinhauer, B., Kann, P., Fuder, H. Naunyn Schmiedebergs Arch. Pharmacol. (1990) [Pubmed]
  10. Receptor binding profiles of some selective muscarinic antagonists. Nilvebrant, L., Sparf, B. Eur. J. Pharmacol. (1988) [Pubmed]
  11. Characterization of muscarinic autoreceptors in the rabbit hippocampus and caudate nucleus. Stoll, C., Schwarzwälder, U., Johann, S., Lambrecht, G., Hertting, G., Feuerstein, T.J., Jackisch, R. Neurochem. Res. (2003) [Pubmed]
  12. Human prostate muscarinic receptor subtypes. Ruggieri, M.R., Colton, M.D., Wang, P., Wang, J., Smyth, R.J., Pontari, M.A., Luthin, G.R. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  13. Binding and functional properties of antimuscarinics of the hexocyclium/sila-hexocyclium and hexahydro-diphenidol/hexahydro-sila-diphenidol type to muscarinic receptor subtypes. Waelbroeck, M., Tastenoy, M., Camus, J., Christophe, J., Strohmann, C., Linoh, H., Zilch, H., Tacke, R., Mutschler, E., Lambrecht, G. Br. J. Pharmacol. (1989) [Pubmed]
WikiGenes - Universities