Disease relevance of Osnervan

• A double-blind, cross-over trial of the effectiveness of piribedil, procyclidine and placebo in the control of parkinsonism induced by fluphenazine decanoate was conducted in sixteen cases of chronic schizophrenia [1].
• Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats [2].
• Female beagle dogs (body weights 9-10 kg) were shaved on the abdominal side, attached with a matrix-type patch (7x7 cm) containing 1.5% of physostigmine plus 6% procyclidine for 2 days, and challenged with subcutaneous injection of serial doses (2-10 LD50) of soman [3].
• Pancreatitis following overdose with amoxapine and procyclidine [4].
• Paradoxical autonomic response to procyclidine in the neuroleptic malignant syndrome [5].

Psychiatry related information on Osnervan

• Benactyzine and procyclidine only increased fine motor activity significantly above vehicle control levels and activity levels returned to vehicle control levels within 2-3 h [6].

High impact information on Osnervan

• Effects of procyclidine on eye movements in schizophrenia [7].
• NMDA receptors might be involved in the impairing effects of procyclidine on cognition [8].
• Results showed that procyclidine overall, relative to placebo, mildly worsened SPEM performance, as indicated by nonsignificantly reduced gain (p=0.08) and increased frequency of intrusive anticipatory saccades during pursuit (p=0.06) [7].
• In the present study, we used a sciatic nerve ligation model that produces a hyperalgesic (neuropathic pain) state in adult rats to evaluate the ability of procyclidine or ethopropazine, either alone or in combination with an alpha(2) adrenergic agonist, to ameliorate neuropathic pain [2].
• In both experiments, procyclidine reduced response amplitude over the pulse-alone trials and heart rate 1-2 h post-administration [9].

Biological context of Osnervan

• In contrast, mecamylamine, methapyrilene and procyclidine had very little effect on the dissociation rate, suggesting a competitive action at the [3H]MK801/phencyclidine binding site [10].
• Physostigmine (0.1 mg/kg) and procyclidine in a dose of 1 mg/kg did not prevent convulsions or seizures when the soman dose was 1.6 x LD50 [11].
• Effects of 10 mg and 15 mg oral procyclidine on critical flicker fusion threshold and cardiac functioning in healthy human subjects [12].
• Pharmacokinetics and Pharmacodynamics of procyclidine in man [13].
• 1. The biotransformation of procyclidine in isolated hepatocytes, prepared from untreated and from phenobarbital-pretreated rats, is described [14].

Anatomical context of Osnervan

• 2 The stereospecific index for procyclidine is not greater than 10, in contrast to 173 for acetylcholine receptors in ileum from the same mice [15].
• However, in contrast to functional data, binding results showed that 4-DAMP hexahydrosiladifenidol and procyclidine did not distinguish between the sites in the smooth muscles and those in the heart [16].
• The affinities of hexahydrosiladefinidol, procyclidine and 4-DAMP were higher in the cortex and parotid gland than in the heart, bladder and ileum [16].
• Metabolism of procyclidine in isolated rat hepatocytes [14].

Associations of Osnervan with other chemical compounds

• Results from [(3)H]MK-801-binding experiments showed that procyclidine inhibits the phencyclidine site at the NMDA receptor in a concentration-dependent manner [11].
• This study determined the effects of procyclidine, an anticholinergic drug, on PPI in patients with schizophrenia given risperidone or quetiapine and not on any anticholinergic drugs, employing a placebo-controlled, cross-over design [17].
• A sensitive (50-100 pg/ml) method is described for the analysis of the anticholinergic drugs cycrimine, procyclidine and trihexyphenidyl by capillary gas chromatography with flame thermionic detection [18].
• Long-term effects of L-dopa and procyclidine on neuroleptic-induced extrapyramidal and schizophrenic symptoms [19].

Gene context of Osnervan

• Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4 [20].

Analytical, diagnostic and therapeutic context of Osnervan

• A total of 13 patients completed a double-blind placebo-controlled crossover design, receiving 15 mg procyclidine and placebo [7].
• Effects of procyclidine on prepulse inhibition of the acoustic startle response in healthy human volunteers [9].
• METHODS: Subjects underwent testing for PPI on two occasions: once after the oral administration of a placebo and once after the oral administration of procyclidine in two separate experiments [9].
• Analysis of procyclidine in human plasma and urine by gas-liquid chromatography [21].
• Taken together, it is suggested that the combination of physostigmine and procyclidine, at adequate doses, could be a choice to provide the victims of organophosphate poisoning with chance of intensive care for survival and neuroprotection [22].

References