The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Kemadrin     1-cyclohexyl-1-phenyl-3- pyrrolidin-1-yl...

Synonyms: Osnervan, Arpicolin, Elorine, Kemadrine, Lergine, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Osnervan


Psychiatry related information on Osnervan


High impact information on Osnervan

  • Effects of procyclidine on eye movements in schizophrenia [7].
  • NMDA receptors might be involved in the impairing effects of procyclidine on cognition [8].
  • Results showed that procyclidine overall, relative to placebo, mildly worsened SPEM performance, as indicated by nonsignificantly reduced gain (p=0.08) and increased frequency of intrusive anticipatory saccades during pursuit (p=0.06) [7].
  • In the present study, we used a sciatic nerve ligation model that produces a hyperalgesic (neuropathic pain) state in adult rats to evaluate the ability of procyclidine or ethopropazine, either alone or in combination with an alpha(2) adrenergic agonist, to ameliorate neuropathic pain [2].
  • In both experiments, procyclidine reduced response amplitude over the pulse-alone trials and heart rate 1-2 h post-administration [9].

Biological context of Osnervan


Anatomical context of Osnervan


Associations of Osnervan with other chemical compounds


Gene context of Osnervan

  • Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4 [20].

Analytical, diagnostic and therapeutic context of Osnervan


  1. A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism. Mindham, R.H., Lamb, P., Bradley, R. The British journal of psychiatry : the journal of mental science. (1977) [Pubmed]
  2. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Jevtovic-Todorovic, V., Meyenburg, A.P., Olney, J.W., Wozniak, D.F. Neuropharmacology (2003) [Pubmed]
  3. Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs. Kim, W.S., Cho, Y., Kim, J.C., Huang, Z.Z., Park, S.H., Choi, E.K., Shin, S., Nam, S.Y., Kang, J.K., Hwang, S.Y., Kim, Y.B. Eur. J. Pharmacol. (2005) [Pubmed]
  4. Pancreatitis following overdose with amoxapine and procyclidine. Jeffries, J.J., Masson, J. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (1985) [Pubmed]
  5. Paradoxical autonomic response to procyclidine in the neuroleptic malignant syndrome. Balzan, M.V. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1995) [Pubmed]
  6. Dose-response curves and time-course effects of selected anticholinergics on locomotor activity in rats. Sipos, M.L., Burchnell, V., Galbicka, G. Psychopharmacology (Berl.) (1999) [Pubmed]
  7. Effects of procyclidine on eye movements in schizophrenia. Ettinger, U., Kumari, V., Zachariah, E., Galea, A., Crawford, T.J., Corr, P.J., Taylor, D., Das, M., Sharma, T. Neuropsychopharmacology (2003) [Pubmed]
  8. NMDA receptors might be involved in the impairing effects of procyclidine on cognition. Roesler, R., Quevedo, J., Schröder, N. Journal of clinical psychopharmacology. (2003) [Pubmed]
  9. Effects of procyclidine on prepulse inhibition of the acoustic startle response in healthy human volunteers. Kumari, V., Zachariah, E., Galea, A., Mehrotra, R., Taylor, D., Sharma, T. Psychopharmacology (Berl.) (2001) [Pubmed]
  10. [3H]MK801 binding to the N-methyl-D-aspartate receptor reveals drug interactions with the zinc and magnesium binding sites. Reynolds, I.J., Miller, R.J. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  11. Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts. Myhrer, T., Nguyen, N.H., Andersen, J.M., Aas, P. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  12. Effects of 10 mg and 15 mg oral procyclidine on critical flicker fusion threshold and cardiac functioning in healthy human subjects. Sharma, T., Galea, A., Zachariah, E., Das, M., Taylor, D., Ruprah, M., Kumari, V. J. Psychopharmacol. (Oxford) (2002) [Pubmed]
  13. Pharmacokinetics and Pharmacodynamics of procyclidine in man. Whiteman, P.D., Fowle, A.S., Hamilton, M.J., Peck, A.W., Bye, A., Dean, K., Webster, A. Eur. J. Clin. Pharmacol. (1985) [Pubmed]
  14. Metabolism of procyclidine in isolated rat hepatocytes. Rogiers, V., Paeme, G., Sonck, W., Vercruysse, A. Xenobiotica (1987) [Pubmed]
  15. A comparison of stereospecificity at central and peripheral 'muscarine-sensitive' acetylcholine receptors: observations with the enantiomeric forms of procyclidine and tricyclamol. Barlow, R.B., Dawbarn, D., Pycock, C.J. Br. J. Pharmacol. (1981) [Pubmed]
  16. Receptor binding profiles of some selective muscarinic antagonists. Nilvebrant, L., Sparf, B. Eur. J. Pharmacol. (1988) [Pubmed]
  17. Effects of acute procyclidine administration on prepulse inhibition of the startle response in schizophrenia: a double-blind, placebo-controlled study. Kumari, V., Zachariah, E., Galea, A., Jones, H.C., Das, M., Mehrotra, R., Taylor, D., Sharma, T. J. Psychopharmacol. (Oxford) (2003) [Pubmed]
  18. Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids. Owen, J.A., Sribney, M., Lawson, J.S., Delva, N., Letemendia, F.J. J. Chromatogr. (1989) [Pubmed]
  19. Long-term effects of L-dopa and procyclidine on neuroleptic-induced extrapyramidal and schizophrenic symptoms. Chouinard, G., Annable, L., Mercier, P., Turnier, L. Psychopharmacology bulletin. (1987) [Pubmed]
  20. Stereoselectivity of procyclidine binding to muscarinic receptor subtypes M1, M2 and M4. Waelbroeck, M., Camus, J., Tastenoy, M., Lambrecht, G., Mutschler, E., Tacke, R., Christophe, J. Eur. J. Pharmacol. (1990) [Pubmed]
  21. Analysis of procyclidine in human plasma and urine by gas-liquid chromatography. Dean, K., Land, D., Bye, A. J. Chromatogr. (1980) [Pubmed]
  22. Protection by sustained release of physostigmine and procyclidine of soman poisoning in rats. Choi, E.K., Park, D., Yon, J.M., Hur, G.H., Ha, Y.C., Che, J.H., Kim, J., Shin, S., Jang, J.Y., Hwang, S.Y., Seong, Y.H., Kim, D.J., Kim, J.C., Kim, Y.B. Eur. J. Pharmacol. (2004) [Pubmed]
WikiGenes - Universities