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Chemical Compound Review

Ketose     1,2,4,5,6-pentahydroxyhexan- 3-one

Synonyms: AC1L97GH, 56550-EP2295422A2, 56550-EP2298769A1, 56550-EP2308878A2
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Disease relevance of C01383


High impact information on C01383

  • The ketose caused increases in the concentration of fructose 1-phosphate, which reached values known to relieve the inhibition exerted on glucokinase by its regulatory protein [2].
  • The epimeric specificity of the catalytic site of rabbit muscle phosphofructokinase was investigated by testing three ketose phosphates as alternate substrates [3].
  • Transport and phosphorylation of L-sorbose was catalyzed by membrane-bound enzyme IIsor of the phosphoenolpyruvate-dependent carbohydrate:phosphotransferase system, specific for and regulated by this ketose and different from all other enzymes II described thus far [4].
  • Yeast transketolase, in addition to catalyzing the transferase reaction through utilization of two substrates--the donor substrate (ketose) and the acceptor substrate (aldose)--is also able to catalyze a one-substrate reaction with only aldose (glycolaldehyde) as substrate [5].
  • Previous studies showed that carnosine can protect proteins against aldehyde-containing cross-linking agents such as aldose and ketose hexose and triose sugars, and malon-dialdehyde, the lipid peroxidation product [6].

Biological context of C01383


Anatomical context of C01383


Associations of C01383 with other chemical compounds

  • Apart from catalyzing the common two-substrate reaction with ketose as donor substrate and aldose as acceptor substrate, transketolase is also able to catalyze a one-substrate reaction utilizing only ketose (xylulose 5-phosphate) as substrate [12].

Analytical, diagnostic and therapeutic context of C01383


  1. Genetic control of manno(fructo)kinase activity in Escherichia coli. Sproul, A.A., Lambourne, L.T., Jean-Jacques D, J., Kornberg, H.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Fructose administration stimulates glucose phosphorylation in the livers of anesthetized rats. Van Schaftingen, E., Davies, D.R. FASEB J. (1991) [Pubmed]
  3. The fructose 6-phosphate site of phosphofructokinase. Epimeric specificity. Koerner, T.A., Voll, R.J., Ashour, A.L., Younathan, E.S. J. Biol. Chem. (1976) [Pubmed]
  4. L-Sorbose metabolism in Klebsiella pneumoniae and Sor+ derivatives of Escherichia coli K-12 and chemotaxis toward sorbose. Sprenger, G.A., Lengeler, J.W. J. Bacteriol. (1984) [Pubmed]
  5. A hitherto unknown transketolase-catalyzed reaction. Sevostyanova, I.A., Solovjeva, O.N., Kochetov, G.A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  6. Carnosine protects proteins against methylglyoxal-mediated modifications. Hipkiss, A.R., Chana, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  7. Somatic antigens of Pseudomonas aeruginosa. The structure of O-specific polysaccharide chains of P. aeruginosa O10 (Lányi) lipopolysaccharides. Knirel, Y.A., Vinogradov, E.V., Shashkov, A.S., Dmitriev, B.A., Kochetkov, N.K., Stanislavsky, E.S., Mashilova, G.M. Eur. J. Biochem. (1986) [Pubmed]
  8. Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Hipkiss, A.R., Preston, J.E., Himsworth, D.T., Worthington, V.C., Keown, M., Michaelis, J., Lawrence, J., Mateen, A., Allende, L., Eagles, P.A., Abbott, N.J. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  9. Improved procedures for the conjugation of oligosaccharides to protein by reductive amination. Roy, R., Katzenellenbogen, E., Jennings, H.J. Can. J. Biochem. Cell Biol. (1984) [Pubmed]
  10. Plasma D-glucose, D-fructose and insulin responses after oral administration of D-glucose, D-fructose and sucrose to normal rats. Prieto, P.G., Cancelas, J., Villanueva-Peñacarrillo, M.L., Valverde, I., Malaisse, W.J. Journal of the American College of Nutrition. (2004) [Pubmed]
  11. Ketose induced respiratory inhibition in isolated hepatocytes. Martínez, P., Carrascosa, J.M., Núñez de Castro, I. Rev. Esp. Fisiol. (1987) [Pubmed]
  12. One-substrate transketolase-catalyzed reaction. Bykova, I.A., Solovjeva, O.N., Meshalkina, L.E., Kovina, M.V., Kochetov, G.A. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  13. In situ product removal of ketoses by immobilized 3-amino phenyl boronic acid: effect of immobilization method on pH profile. Dukler, A., Freeman, A. Biotechnol. Bioeng. (2001) [Pubmed]
  14. The non-oxidative degradation of ascorbic acid at physiological conditions. Simpson, G.L., Ortwerth, B.J. Biochim. Biophys. Acta (2000) [Pubmed]
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