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Chemical Compound Review

Ribothymidine     1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: Ribosylthymine, PubChem14166, SureCN29298, CHEMBL106175, AG-D-90575, ...
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  • Using X-ray crystallography, we have determined the structures of three A-form DNA duplexes containing the following 2'-O-modified ribothymidine building blocks: 2'-O-methoxyethyl ribo-T, 2'-O-methyl[tri(oxyethyl)] ribo-T, and 2'-O-ethoxymethylene ribo-T [27].


  1. Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. Agarwalla, S., Kealey, J.T., Santi, D.V., Stroud, R.M. J. Biol. Chem. (2002) [Pubmed]
  2. Methylenetetrahydrofolate-dependent biosynthesis of ribothymidine in transfer RNA of Streptococcus faecalis. Evidence for reduction of the 1-carbon unit by FADH2. Delk, A.S., Nagle, D.P., Rabinowitz, J.C. J. Biol. Chem. (1980) [Pubmed]
  3. Biosynthesis of ribothymidine in the transfer RNA of Streptococcus faecalis and Bacillus subtilis. A methylation of RNA involving 5,10-methylenetetrahydrofolate. Delk, A.S., Romeo, J.M., Nagle, D.P., Rabinowitz, J.C. J. Biol. Chem. (1976) [Pubmed]
  4. Formylatable methionine transfer RNA from Mycoplasma: purification and comparison of partial nucleotide sequences with those of other prokaryotic initiator tRNAs. Walker, R.T., RajBhandary, U.L. Nucleic Acids Res. (1975) [Pubmed]
  5. Pseudouridine and ribothymidine formation in the tRNA-like domain of turnip yellow mosaic virus RNA. Becker, H.F., Motorin, Y., Florentz, C., Giegé, R., Grosjean, H. Nucleic Acids Res. (1998) [Pubmed]
  6. Defects in modification of cytoplasmic and mitochondrial transfer RNAs are caused by single nuclear mutations. Hopper, A.K., Furukawa, A.H., Pham, H.D., Martin, N.C. Cell (1982) [Pubmed]
  7. The gene for a tRNA modifying enzyme, m5U54-methyltransferase, is essential for viability in Escherichia coli. Persson, B.C., Gustafsson, C., Berg, D.E., Björk, G.R. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Role of ribothymidine in mammalian tRNAPhe. Roe, B.A., Tsen, H.Y. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  9. Temperature-dependent biosynthesis of 2-thioribothymidine of Thermus thermophilus tRNA. Shigi, N., Suzuki, T., Terada, T., Shirouzu, M., Yokoyama, S., Watanabe, K. J. Biol. Chem. (2006) [Pubmed]
  10. Utilization of an Escherichia coli mutant for carbon-13 enrichment of tRNA for NMR studies. Agris, P.F., Fujiwara, F.G., Schmidt, C.F., Loeppky, R.N. Nucleic Acids Res. (1975) [Pubmed]
  11. Role of ribothymidine in the thermal stability of transfer RNA as monitored by proton magnetic resonance. Davanloo, P., Sprinzl, M., Watanabe, K., Albani, M., Kersten, H. Nucleic Acids Res. (1979) [Pubmed]
  12. Identification of modified nucleosides in intact transfer ribonucleic acid by pyrolysis-electron impact-collisional activation mass spectrometry. Puzo, G., Wiebers, J.L. Nucleic Acids Res. (1981) [Pubmed]
  13. Occurrence of 1-methyladenosine and absence of ribothymidine in transfer ribonucleic acid of Mycobacterium smegmatis. Vani, B.R., Ramakrishnan, T., Taya, Y., Noguchi, S., Yamaizumi, Z., Nishimura, S. J. Bacteriol. (1979) [Pubmed]
  14. Tetrahydrofolate-dependent biosynthesis of ribothymidine in transfer ribonucleic acids of Gram-positive bacteria. Schmidt, W., Arnold, H.H., Kersten, H. J. Bacteriol. (1977) [Pubmed]
  15. Acetylation and cleavage of purine nucleosides. Synthesis of 6-azauridine, 5-fluorouridine, and 5-methyluridine. Beránek, J., Hrebabecký, H. Nucleic Acids Res. (1976) [Pubmed]
  16. Nuclear magnetic resonance studies on transfer ribonucleic acid: assignment of AU tertiary resonances. Hurd, R.E., Reid, B.R. Biochemistry (1979) [Pubmed]
  17. Cloning and restriction mapping of the trmA gene coding for transfer ribonucleic acid (5-methyluridine)-methyltransferase in Escherichia coli K-12. Ny, T., Björk, G.R. J. Bacteriol. (1980) [Pubmed]
  18. Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine. Pioszak, A.A., Murayama, K., Nakagawa, N., Ebihara, A., Kuramitsu, S., Shirouzu, M., Yokoyama, S. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2005) [Pubmed]
  19. The tRNA-like domains of E coli and A.aeolicus transfer-messenger RNA: structural and functional studies. Gaudin, C., Nonin-Lecomte, S., Tisné, C., Corvaisier, S., Bordeau, V., Dardel, F., Felden, B. J. Mol. Biol. (2003) [Pubmed]
  20. Tubercidin and isopropylureidopurine--inhibitors of ribothymidine synthesis in vitro. Wainfan, E., Chu, J., Chheda, G.B. Biochem. Pharmacol. (1975) [Pubmed]
  21. Isolation and identification of apoptosis inducing nucleosides from CD57(+)HLA-DRbright natural suppressor cell line. Mori, T., Guo, M.W., Li, X., Xu, J.P., Mori, E. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  22. Transductional mapping of gene trmA responsible for the production of 5-methyluridine in transfer ribonucleic acid of Escherichia coli. Björk, G.R. J. Bacteriol. (1975) [Pubmed]
  23. Beta-L-thymidine 5'-triphosphate analogs as DNA polymerase substrates. Van Draanen, N.A., Tucker, S.C., Boyd, F.L., Trotter, B.W., Reardon, J.E. J. Biol. Chem. (1992) [Pubmed]
  24. Study of yeast mitochondrial tRNAs by two-dimensional polyacrylamide gel electrophoresis: characterization of isoaccepting species and search for imported cytoplasmic tRNAs. Martin, R.P., Schneller, J.M., Stahl, A.J., Dirheimer, G. Nucleic Acids Res. (1977) [Pubmed]
  25. Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase. Lee, T.T., Agarwalla, S., Stroud, R.M. Structure (Camb.) (2004) [Pubmed]
  26. Purification and characterization of uridine and thymidine phosphorylase from Lactobacillus casei. Avraham, Y., Grossowicz, N., Yashphe, J. Biochim. Biophys. Acta (1990) [Pubmed]
  27. Correlating structure and stability of DNA duplexes with incorporated 2'-O-modified RNA analogues. Tereshko, V., Portmann, S., Tay, E.C., Martin, P., Natt, F., Altmann, K.H., Egli, M. Biochemistry (1998) [Pubmed]
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