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Chemical Compound Review

menaquinol-7     2-[(2E,6E,10E,14E,18E,22E)- 3,7,11,15,19,23...

Synonyms: menaquinol(7), MKH2-7, CHEBI:64834, CPD-12125, AC1L9LDY
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Disease relevance of Menaquinone-7


High impact information on Menaquinone-7


Chemical compound and disease context of Menaquinone-7


Biological context of Menaquinone-7


Anatomical context of Menaquinone-7

  • The menaquinone-7 level in feces was similar to that in non-warfarin-administered patients [13].
  • A slightly halophilic, extremely halotolerant, alkaliphilic, and facultatively anaerobic rod bacterium was isolated from a decomposing marine alga collected in Okinawa, Japan. The isolate, designated O15-7(T), was Gram-positive, endospore-forming, catalase-positive, menaquinone-7-possessing bacterium that is motile by peritrichous flagella [14].

Associations of Menaquinone-7 with other chemical compounds


Analytical, diagnostic and therapeutic context of Menaquinone-7


  1. Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus. Koike-Takeshita, A., Koyama, T., Ogura, K. J. Biol. Chem. (1997) [Pubmed]
  2. Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex. Zhang, Y.W., Koyama, T., Marecak, D.M., Prestwich, G.D., Maki, Y., Ogura, K. Biochemistry (1998) [Pubmed]
  3. Menaquinone-7 in the reaction center complex of the green sulfur bacterium Chlorobium vibrioforme functions as the electron acceptor A1. Kjaer, B., Frigaard, N.U., Yang, F., Zybailov, B., Miller, M., Golbeck, J.H., Scheller, H.V. Biochemistry (1998) [Pubmed]
  4. Zeaxanthin and menaquinone-7 biosynthesis in Sphingobacterium multivorum via the methylerythritol phosphate pathway. Rosa-Putra, S., Hemmerlin, A., Epperson, J., Bach, T.J., Guerra, L.H., Rohmer, M. FEMS Microbiol. Lett. (2001) [Pubmed]
  5. Effect of vitamin K2 (menaquinone-7) on bone metabolism in the femoral-metaphyseal tissues of normal and skeletal-unloaded rats: enhancement with zinc. Ehara, Y., Takahashi, H., Hanahisa, Y., Yamaguchi, M. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1996) [Pubmed]
  6. The effects of vitamin K on the generation of des-gamma-carboxy prothrombin (PIVKA-II) in patients with hepatocellular carcinoma. Sakon, M., Monden, M., Gotoh, M., Kobayashi, K., Kanai, T., Umeshita, K., Endoh, W., Mori, T. Am. J. Gastroenterol. (1991) [Pubmed]
  7. Olivibacter sitiensis gen. nov., sp. nov., isolated from alkaline olive-oil mill wastes in the region of Sitia, Crete. Ntougias, S., Fasseas, C., Zervakis, G.I. Int. J. Syst. Evol. Microbiol. (2007) [Pubmed]
  8. The gerC locus of Bacillus subtilis, required for menaquinone biosynthesis, is concerned only indirectly with spore germination. Leatherbarrow, A.J., Yazdi, M.A., Curson, J.P., Moir, A. Microbiology (Reading, Engl.) (1998) [Pubmed]
  9. Menaquinone-7 regulates gene expression in osteoblastic MC3T3E1 cells. Katsuyama, H., Saijoh, K., Otsuki, T., Tomita, M., Fukunaga, M., Sunami, S. Int. J. Mol. Med. (2007) [Pubmed]
  10. Menaquinone-7 regulates the expressions of osteocalcin, OPG, RANKL and RANK in osteoblastic MC3T3E1 cells. Katsuyama, H., Otsuki, T., Tomita, M., Fukunaga, M., Fukunaga, T., Suzuki, N., Saijoh, K., Fushimi, S., Sunami, S. Int. J. Mol. Med. (2005) [Pubmed]
  11. Construction of a Bacillus subtilis (natto) with high productivity of vitamin K2 (menaquinone-7) by analog resistance. Tsukamoto, Y., Kasai, M., Kakuda, H. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
  12. Stimulatory effect of menaquinone-7 (vitamin K2) on osteoblastic bone formation in vitro. Yamaguchi, M., Sugimoto, E., Hachiya, S. Mol. Cell. Biochem. (2001) [Pubmed]
  13. Anticoagulant effects of warfarin and kinetics of K vitamins in blood and feces. Nakamura, K., Toyohira, H., Kariyazono, H., Ishibashi, M., Saigenji, H., Shimokawa, S., Taira, A. Artery (1994) [Pubmed]
  14. Paraliobacillus ryukyuensis gen. nov., sp. nov., a new Gram-positive, slightly halophilic, extremely halotolerant, facultative anaerobe isolated from a decomposing marine alga. Ishikawa, M., Ishizaki, S., Yamamoto, Y., Yamasato, K. J. Gen. Appl. Microbiol. (2002) [Pubmed]
  15. Prolonged intake of fermented soybean (natto) diets containing vitamin K2 (menaquinone-7) prevents bone loss in ovariectomized rats. Yamaguchi, M., Kakuda, H., Gao, Y.H., Tsukamoto, Y. J. Bone Miner. Metab. (2000) [Pubmed]
  16. Production of menaquinones by lactic acid bacteria. Morishita, T., Tamura, N., Makino, T., Kudo, S. J. Dairy Sci. (1999) [Pubmed]
  17. Effects of temperature on biodegradation characteristics of organic pollutants and microbial community in a solid phase aerobic bioreactor treating high strength organic wastewater. Lim, B.R., Huang, X., Hu, H.Y., Goto, N., Fujie, K. Water Sci. Technol. (2001) [Pubmed]
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