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Chemical Compound Review

Diosmetin     5,7-dihydroxy-2-(3-hydroxy-4- methoxy...

Synonyms: Diosmetine, Pillon, AC1NQYQA, CHEMBL90568, S2380_Selleck, ...
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Disease relevance of C10038

  • Diosmetin inhibited 3H-dopamine uptake in control and differentiated neuroblastoma cells, as well as in small-cell lung carcinoma cells [1].

High impact information on C10038


Biological context of C10038


Anatomical context of C10038


Associations of C10038 with other chemical compounds


Analytical, diagnostic and therapeutic context of C10038

  • In this study, we investigate the metabolism of diosmetin as a model compound in the rat, particularly its level in blood after treatment (100 mg/kg, po) and the presence of its glucuronide(s) in both blood and urine [6].
  • A validated HPLC determination of the flavone aglycone diosmetin in human plasma [11].


  1. Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines. Sher, E., Codignola, A., Biancardi, E., Cova, D., Clementi, F. Pharmacol. Res. (1992) [Pubmed]
  2. Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. Ciolino, H.P., Wang, T.T., Yeh, G.C. Cancer Res. (1998) [Pubmed]
  3. Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. Ko, W.C., Shih, C.M., Lai, Y.H., Chen, J.H., Huang, H.L. Biochem. Pharmacol. (2004) [Pubmed]
  4. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Morel, I., Lescoat, G., Cogrel, P., Sergent, O., Pasdeloup, N., Brissot, P., Cillard, P., Cillard, J. Biochem. Pharmacol. (1993) [Pubmed]
  5. Resistance of MCF-7 cells to dimethylbenz(a)anthracene-induced apoptosis is due to reduced CYP1A1 expression. Ciolino, H.P., Dankwah, M., Yeh, G.C. Int. J. Oncol. (2002) [Pubmed]
  6. In vivo and in vitro glucuronidation of the flavonoid diosmetin in rats. Boutin, J.A., Meunier, F., Lambert, P.H., Hennig, P., Bertin, D., Serkiz, B., Volland, J.P. Drug Metab. Dispos. (1993) [Pubmed]
  7. Protective effect of diosmetin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes. Villa, P., Cova, D., De Francesco, L., Guaitani, A., Palladini, G., Perego, R. Toxicology (1992) [Pubmed]
  8. Degradation of flavonoid aglycones by rabbit, rat and human fecal flora. Lin, Y.T., Hsiu, S.L., Hou, Y.C., Chen, H.Y., Chao, P.D. Biol. Pharm. Bull. (2003) [Pubmed]
  9. Schizonodiol, Schizonol, and Schizonepetosides D and E, Monoterpenoids of Schizonepeta tenuifolia Spikes1. Oshima, Y., Takata, S., Hikino, H. Planta Med. (1989) [Pubmed]
  10. Anti-inflammatory effects of South American Tanacetum vulgare. Schinella, G.R., Giner, R.M., Recio, M.C., Mordujovich de Buschiazzo, P., Ríos, J.L., Máñez, S. J. Pharm. Pharmacol. (1998) [Pubmed]
  11. A validated HPLC determination of the flavone aglycone diosmetin in human plasma. Kanaze, F.I., Bounartzi, M.I., Niopas, I. Biomed. Chromatogr. (2004) [Pubmed]
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