Gene Review:
PDE5 - phosphodiesterase isozyme 5
Sus scrofa
- Phosphodiesterase 5 and effects of sildenafil on cerebral arteries of man and guinea pig. Kruuse, C., Khurana, T.S., Rybalkin, S.D., Birk, S., Engel, U., Edvinsson, L., Olesen, J. Eur. J. Pharmacol. (2005)
- Vardenafil increases coronary flow response to hypercapnic acidosis in isolated guinea pig heart. Brand, M., Deussen, A. Basic Res. Cardiol. (2007)
- Sildenafil extends survival and graft function in a large animal lung transplantation model. Korom, S., Hillinger, S., Cardell, M., Zhai, W., Tan, Q., Dutly, A., Leskosek, B., Weder, W. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2006)
- Signaling molecules in overcirculation-induced pulmonary hypertension in piglets: effects of sildenafil therapy. Rondelet, B., Kerbaul, F., Van Beneden, R., Motte, S., Fesler, P., Hubloue, I., Remmelink, M., Brimioulle, S., Salmon, I., Ketelslegers, J.M., Naeije, R. Circulation (2004)
- Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease. Toward, T.J., Smith, N., Broadley, K.J. Am. J. Respir. Crit. Care Med. (2004)
- 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. Watanabe, N., Adachi, H., Takase, Y., Ozaki, H., Matsukura, M., Miyazaki, K., Ishibashi, K., Ishihara, H., Kodama, K., Nishino, M., Kakiki, M., Kabasawa, Y. J. Med. Chem. (2000)
- 1-Arylnaphthalene lignan: a novel scaffold for type 5 phosphodiesterase inhibitor. Ukita, T., Nakamura, Y., Kubo, A., Yamamoto, Y., Takahashi, M., Kotera, J., Ikeo, T. J. Med. Chem. (1999)
- 4-Benzylamino-1-chloro-6-substituted phthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. Watanabe, N., Kabasawa, Y., Takase, Y., Matsukura, M., Miyazaki, K., Ishihara, H., Kodama, K., Adachi, H. J. Med. Chem. (1998)
- Postnatal maturation of phosphodiesterase 5 (PDE5) in piglet pulmonary arteries: activity, expression, effects of PDE5 inhibitors, and role of the nitric oxide/cyclic GMP pathway. Moreno, L., Losada, B., Cogolludo, A., Lodi, F., Lugnier, C., Villamor, E., Moro, M., Tamargo, J., Pérez-Vizcaíno, F. Pediatr. Res. (2004)
- Contribution of phosphodiesterase isoenzymes and cyclic nucleotide efflux to the regulation of cyclic GMP levels in aortic smooth muscle cells. Mercapide, J., Santiago, E., Alberdi, E., Martinez-Irujo, J.J. Biochem. Pharmacol. (1999)
- Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. Ko, W.C., Shih, C.M., Lai, Y.H., Chen, J.H., Huang, H.L. Biochem. Pharmacol. (2004)
- Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Bouley, R., Pastor-Soler, N., Cohen, O., McLaughlin, M., Breton, S., Brown, D. Am. J. Physiol. Renal Physiol. (2005)
- Bronchial anti-spasmogenic effects and selectivity of T-440, phosphodiesterase type 4 inhibitor, in the dog. Yamagata, S., Wada, K., Sugaya, T., Oka, K., Kaminuma, O., Kikkawa, H., Ikezawa, K. Biol. Pharm. Bull. (1997)