Chemical Compound Review:
Barosmin 5-hydroxy-2-(3-hydroxy-4- methoxy-phenyl)-7...
Synonyms:
Diosmine, Diovenor, Diosmil, Diosminum, Flebosten, ...
Bouskela,
Cyrino,
Lerond,
Ciolino,
Wang,
Yeh,
Melzig,
Loose,
Struckmann,
Danielsson,
Norgren,
Truedsson,
Andreasson,
Danielsson,
Nilsson,
Swartbol,
- Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination. Tanaka, T., Makita, H., Ohnishi, M., Mori, H., Satoh, K., Hara, A., Sumida, T., Fukutani, K., Tanaka, T., Ogawa, H. Cancer Res. (1997)
- Modulation of N-methyl-N-amylnitrosamine-induced rat oesophageal tumourigenesis by dietary feeding of diosmin and hesperidin, both alone and in combination. Tanaka, T., Makita, H., Kawabata, K., Mori, H., Kakumoto, M., Satoh, K., Hara, A., Sumida, T., Fukutani, K., Tanaka, T., Ogawa, H. Carcinogenesis (1997)
- Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin. Tanaka, T., Makita, H., Kawabata, K., Mori, H., Kakumoto, M., Satoh, K., Hara, A., Sumida, T., Tanaka, T., Ogawa, H. Carcinogenesis (1997)
- Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids. Thanapongsathorn, W., Vajrabukka, T. Dis. Colon Rectum (1992)
- Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS. Crespo, M.E., Gálvez, J., Cruz, T., Ocete, M.A., Zarzuelo, A. Planta Med. (1999)
- Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. Ciolino, H.P., Wang, T.T., Yeh, G.C. Cancer Res. (1998)
- Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice. Yang, M., Tanaka, T., Hirose, Y., Deguchi, T., Mori, H., Kawada, Y. Int. J. Cancer (1997)
- Flavonoid treatment in patients with healed venous ulcer: flow cytometry analysis suggests increased CD11b expression on neutrophil granulocytes in the circulation. Danielsson, G., Norgren, L., Truedsson, L., Andreasson, A., Danielsson, P., Nilsson, A., Swartbol, P. Vascular medicine (London, England) (2003)
- Effects of citrus flavonoids on the mutagenicity of heterocyclic amines and on cytochrome P450 1A2 activity. Bear, W.L., Teel, R.W. Anticancer Res. (2000)
- Protective effect of diosmetin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes. Villa, P., Cova, D., De Francesco, L., Guaitani, A., Palladini, G., Perego, R. Toxicology (1992)
- Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines. Sher, E., Codignola, A., Biancardi, E., Cova, D., Clementi, F. Pharmacol. Res. (1992)
- Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency. Cesarone, M.R., Belcaro, G., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Di Renzo, A., Ruffini, I., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., Cornelli, U., Hosoi, M., Cacchio, M. Angiology. (2006)
- Pharmacokinetic studies of diosmin and diosmetin in perfused rat liver. Perego, R., Beccaglia, P., Angelini, M., Villa, P., Cova, D. Xenobiotica (1993)
- Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity by diosmin. Melzig, M.F., Loose, R. Die Pharmazie. (1999)
- Biochemical mediators involved in the inflammatory reaction. Protective activity of S 5682. Vargaftig, B.B. International angiology : a journal of the International Union of Angiology. (1988)
- Pharmacokinetics and metabolism of oral diosmin in healthy volunteers. Cova, D., De Angelis, L., Giavarini, F., Palladini, G., Perego, R. International journal of clinical pharmacology, therapy, and toxicology. (1992)
- Diosmin-induced increase in sensitivity to Ca2+ of the smooth muscle contractile apparatus in the rat isolated femoral vein. Savineau, J.P., Marthan, R. Br. J. Pharmacol. (1994)
- Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils. Cypriani, B., Limasset, B., Carrié, M.L., Le Doucen, C., Roussie, M., de Paulet, A.C., Damon, M. Biochem. Pharmacol. (1993)
- Effects of the phlebotropic drug Daflon 500 mg on postischemic reperfusion injury in striated skin muscle: a histomorphologic study in the hamster. Pickelmann, S., Nolte, D., Leiderer, R., Möllmann, M., Schütze, E., Messmer, K. J. Lab. Clin. Med. (1999)
- The effect of the flavonoid diosmin, grape seed extract and red wine on the pulmonary metastatic B16F10 melanoma. Martínez, C., Vicente, V., Yáñez, J., Alcaraz, M., Castells, M.T., Canteras, M., Benavente-García, O., Castillo, J. Histol. Histopathol. (2005)
- Distribution of Flavone Glycoside Diosmin in Hyssopus officinalis Plants: Changes During Growth. Marin, F.R., Ortuño, A., Benavente-Garcia, O., Del Rio, J.A. Planta Med. (1998)
- Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations. Kanaze, F.I., Gabrieli, C., Kokkalou, E., Georgarakis, M., Niopas, I. Journal of pharmaceutical and biomedical analysis. (2003)
- Effects of citrus phytochemicals on liver and lung cytochrome P450 activity and on the in vitro metabolism of the tobacco-specific nitrosamine NNK. Bear, W.L., Teel, R.W. Anticancer Res. (2000)
- Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin. Martínez Conesa, C., Vicente Ortega, V., Yáñez Gascón, M.J., Alcaraz Baños, M., Canteras Jordana, M., Benavente-García, O., Castillo, J. J. Agric. Food Chem. (2005)
- Effects of plant-derived phenols on rat liver cytochrome P450 2B1 activity. Huynh, H.T., Teel, R.W. Anticancer Res. (2002)
- The influence of the fibrinolytic system on the affinity of fibrinogen for the endothelial-plasma interface. Witte, S. Thromb. Res. (1988)
- Comparative effect of tropolone and diosmin on venous COMT and sympathetic activity in rat. Boudet, C., Peyrin, L. Archives internationales de pharmacodynamie et de thérapie. (1986)
- Leukocyte adhesion after oxidant challenge in the hamster cheek pouch microcirculation. Bouskela, E., Cyrino, F.Z., Lerond, L. J. Vasc. Res. (1999)
- Clinical efficacy of micronized purified flavonoid fraction: an overview. Struckmann, J.R. J. Vasc. Res. (1999)
- The effect of diosmin hesperidin on intestinal ischaemia--reperfusion injury. Pehlivan, M., Hazinedaroglu, S.M., Kayaoglu, H.A., Erkek, A.B., Keklik, T., Canbolat, O., Kocak, S. Acta chirurgica Belgica. (2004)