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Chemical Compound Review

Vogonin     5,7-dihydroxy-8-methoxy-2- phenyl-chromen-4...

Synonyms: Wogonin, wagonin, AC1NQYXJ, CHEMBL16171, SureCN139083, ...
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Disease relevance of C10197


High impact information on C10197


Chemical compound and disease context of C10197


Biological context of C10197


Anatomical context of C10197


Associations of C10197 with other chemical compounds


Gene context of C10197


Analytical, diagnostic and therapeutic context of C10197


  1. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Bonham, M., Posakony, J., Coleman, I., Montgomery, B., Simon, J., Nelson, P.S. Clin. Cancer Res. (2005) [Pubmed]
  2. Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Chi, Y.S., Lim, H., Park, H., Kim, H.P. Biochem. Pharmacol. (2003) [Pubmed]
  3. Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities. Ueng, Y.F., Shyu, C.C., Liu, T.Y., Oda, Y., Lin, Y.L., Liao, J.F., Chen, C.F. Biochem. Pharmacol. (2001) [Pubmed]
  4. Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. Hu, Y., Yang, Y., You, Q.D., Liu, W., Gu, H.Y., Zhao, L., Zhang, K., Wang, W., Wang, X.T., Guo, Q.L. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  5. Wogonin sensitizes resistant malignant cells to TNF{alpha}- and TRAIL-induced apoptosis. Fas, S.C., Baumann, S., Zhu, J.Y., Giaisi, M., Treiber, M.K., Mahlknecht, U., Krammer, P.H., Li-Weber, M. Blood (2006) [Pubmed]
  6. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. Chang, Y.L., Shen, J.J., Wung, B.S., Cheng, J.J., Wang, D.L. Mol. Pharmacol. (2001) [Pubmed]
  7. Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids. Shen, S.C., Lin, C.W., Lee, H.M., Chien, L.L., Chen, Y.C. Neuroscience (2006) [Pubmed]
  8. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. Zhao, Y., Li, H., Gao, Z., Gong, Y., Xu, H. Eur. J. Pharmacol. (2006) [Pubmed]
  9. Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. Chang, W.H., Chen, C.H., Lu, F.J. Planta Med. (2002) [Pubmed]
  10. Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. Chen, Y.C., Shen, S.C., Lee, W.R., Lin, H.Y., Ko, C.H., Shih, C.M., Yang, L.L. Arch. Toxicol. (2002) [Pubmed]
  11. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. Lee, H., Kim, Y.O., Kim, H., Kim, S.Y., Noh, H.S., Kang, S.S., Cho, G.J., Choi, W.S., Suk, K. FASEB J. (2003) [Pubmed]
  12. Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. Lee, W.R., Shen, S.C., Lin, H.Y., Hou, W.C., Yang, L.L., Chen, Y.C. Biochem. Pharmacol. (2002) [Pubmed]
  13. The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation. Ohtake, N., Yamamoto, M., Takeda, S., Aburada, M., Ishige, A., Watanabe, K., Inoue, M. Eur. J. Pharmacol. (2005) [Pubmed]
  14. Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. Cho, J., Lee, H.K. Eur. J. Pharmacol. (2004) [Pubmed]
  15. Wogonin Inhibits IL-6-Induced Angiogenesis via Down-Regulation of VEGF and VEGFR-1, not VEGFR-2. Lin, C.M., Chang, H., Chen, Y.H., Wu, I.H., Chiu, J.H. Planta Med. (2006) [Pubmed]
  16. Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Chi, Y.S., Cheon, B.S., Kim, H.P. Biochem. Pharmacol. (2001) [Pubmed]
  17. Wogonin inhibits inducible prostaglandin E(2) production in macrophages. Wakabayashi, I., Yasui, K. Eur. J. Pharmacol. (2000) [Pubmed]
  18. Pharmacological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. Chung, C.P., Park, J.B., Bae, K.H. Planta Med. (1995) [Pubmed]
  19. Antiproliferative effect of baicalein, a flavonoid from a Chinese herb, on vascular smooth muscle cell. Huang, H.C., Wang, H.R., Hsieh, L.M. Eur. J. Pharmacol. (1994) [Pubmed]
  20. Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Ma, Z., Otsuyama, K., Liu, S., Abroun, S., Ishikawa, H., Tsuyama, N., Obata, M., Li, F.J., Zheng, X., Maki, Y., Miyamoto, K., Kawano, M.M. Blood (2005) [Pubmed]
  21. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Kim, H.K., Cheon, B.S., Kim, Y.H., Kim, S.Y., Kim, H.P. Biochem. Pharmacol. (1999) [Pubmed]
  22. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Hui, K.M., Huen, M.S., Wang, H.Y., Zheng, H., Sigel, E., Baur, R., Ren, H., Li, Z.W., Wong, J.T., Xue, H. Biochem. Pharmacol. (2002) [Pubmed]
  23. Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. Lee, S.O., Jeong, Y.J., Yu, M.H., Lee, J.W., Hwangbo, M.H., Kim, C.H., Lee, I.S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  24. Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. Chi, Y.S., Kim, H.P. Prostaglandins Leukot. Essent. Fatty Acids (2005) [Pubmed]
  25. Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2, not VEGFR-1. Lin, C.M., Chang, H., Chen, Y.H., Li, S.Y., Wu, I.H., Chiu, J.H. Int. Immunopharmacol. (2006) [Pubmed]
  26. Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line. Nakamura, N., Hayasaka, S., Zhang, X.Y., Nagaki, Y., Matsumoto, M., Hayasaka, Y., Terasawa, K. Exp. Eye Res. (2003) [Pubmed]
  27. Tumor necrosis factor-producing activity of wogonin in RAW 264.7 murine macrophage cell line. Chiu, J.H., Lay, I.S., Su, M.Y., Chiu, H.L., Chiu, A.C., Lui, W.Y., Wu, C.W. Planta Med. (2002) [Pubmed]
  28. Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. Park, B.K., Heo, M.Y., Park, H., Kim, H.P. Eur. J. Pharmacol. (2001) [Pubmed]
  29. Binding of wogonin to human gammaglobulin. Liu, Y., He, W., Gao, W., Hu, Z., Chen, X. Int. J. Biol. Macromol. (2005) [Pubmed]
  30. Wogonin inhibits N-acetyltransferase activity and gene expression in human leukemia HL-60 cells. Yu, C.S., Yu, F.S., Chuang, Y.C., Lu, H.F., Lin, S.Y., Chiu, T.H., Chung, J.G. Anticancer Res. (2005) [Pubmed]
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