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MeSH Review

Garcinia

 
 
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Disease relevance of Garcinia

 

High impact information on Garcinia

  • Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial [5].
  • CONTEXT: Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial enzyme adenosine triphosphate-citrate (pro-3S)-lyase [5].
  • Here we report that garcinol, a polyisoprenylated benzophenone derivative from Garcinia indica fruit rind, is a potent inhibitor of histone acetyltransferases p300 (IC50 approximately 7 microm) and PCAF (IC50 approximately 5 microm) both in vitro and in vivo [6].
  • The authors have determined that the tropical tree species mangosteen (Garcinia mangostana) stores 18:0 (stearate) in its seed oil in amounts of up to 56% by weight [7].
  • Characterization of acyl-ACP thioesterases of mangosteen (Garcinia mangostana) seed and high levels of stearate production in transgenic canola [7].
 

Biological context of Garcinia

 

Anatomical context of Garcinia

 

Associations of Garcinia with chemical compounds

  • Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anticarcinogenic activities [14].
  • Three novel phloroglucinol derivatives, garcinielliptones F (1), H (3), and I (4), and two novel terpenoids, garcinielliptones G (2) and J (5), with a new skeleton have been isolated from the seeds of Garcinia subelliptica [15].
  • The values of apparent S0.5 for total isocitrate and total garcinia acid are similar with both enzymes; the apparent S0.5 of total homoisocitrate is two- to threefold higher than that of total isocitrate with the DPN-linked enzyme [16].
  • Regioselective synthesis of the bridged tricyclic core of Garcinia natural products via intramolecular aryl acrylate cycloadditions [17].
  • We investigated the possible antioxidant effects of mangostin, isolated from Garcinia mangostana, on metal ion dependent (Cu2+) and independent (aqueous peroxyl radicals) oxidation of human LDL [18].
 

Gene context of Garcinia

  • Effect of Garcinia cambogia extract on serum leptin and insulin in mice [19].
  • Afzeliixanthones A and B, two new prenylated xanthones from Garcinia afzelii ENGL. (Guttiferae) [20].
  • A significant number of studies highlight the efficacy of Super CitriMax (HCA-SX, a novel 60% calcium-potassium salt of HCA derived from Garcinia cambogia) in weight management [21].
  • Determination of organic acids in leaves and rinds of Garcinia indica (Desr.) by LC [22].
  • Studies have demonstrated the efficacy of a novel 60% calcium-potassium salt of HCA derived from Garcinia cambogia (HCA-SX, Super CitriMax) in weight management [23].

References

  1. Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocin-induced diabetes mellitus rats. Adaramoye, O.A., Adeyemi, E.O. J. Pharm. Pharmacol. (2006) [Pubmed]
  2. Antibacterial activity of some Garcinia benzophenone derivatives against methicillin-resistant Staphylococcus aureus. Iinuma, M., Tosa, H., Tanaka, T., Kanamaru, S., Asai, F., Kobayashi, Y., Miyauchi, K., Shimano, R. Biol. Pharm. Bull. (1996) [Pubmed]
  3. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Mahendran, P., Vanisree, A.J., Shyamala Devi, C.S. Phytotherapy research : PTR. (2002) [Pubmed]
  4. Hepatoprotection of D-galactosamine-induced toxicity in mice by purified fractions from Garcinia kola seeds. Adaramoye, O.A., Adeyemi, E.O. Basic & clinical pharmacology & toxicology. (2006) [Pubmed]
  5. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. Heymsfield, S.B., Allison, D.B., Vasselli, J.R., Pietrobelli, A., Greenfield, D., Nunez, C. JAMA (1998) [Pubmed]
  6. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. Balasubramanyam, K., Altaf, M., Varier, R.A., Swaminathan, V., Ravindran, A., Sadhale, P.P., Kundu, T.K. J. Biol. Chem. (2004) [Pubmed]
  7. Characterization of acyl-ACP thioesterases of mangosteen (Garcinia mangostana) seed and high levels of stearate production in transgenic canola. Hawkins, D.J., Kridl, J.C. Plant J. (1998) [Pubmed]
  8. Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract. Farombi, E.O., Tahnteng, J.G., Agboola, A.O., Nwankwo, J.O., Emerole, G.O. Food Chem. Toxicol. (2000) [Pubmed]
  9. Structure-activity relationship of polyisoprenyl benzophenones from Garcinia pyrifera on the tubulin/microtubule system. Roux, D., Hadi, H.A., Thoret, S., Guénard, D., Thoison, O., Païs, M., Sévenet, T. J. Nat. Prod. (2000) [Pubmed]
  10. Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex. Ohia, S.E., Awe, S.O., LeDay, A.M., Opere, C.A., Bagchi, D. Res. Commun. Mol. Pathol. Pharmacol. (2001) [Pubmed]
  11. Inhibition of citrate lyase may aid aerobic endurance. McCarty, M.F. Med. Hypotheses (1995) [Pubmed]
  12. Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines. Matsumoto, K., Akao, Y., Kobayashi, E., Ito, T., Ohguchi, K., Tanaka, T., Iinuma, M., Nozawa, Y. Biol. Pharm. Bull. (2003) [Pubmed]
  13. Attenuation of indomethacin- and HCl/ethanol-induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed. Olaleye, S.B., Farombi, E.O. Phytotherapy research : PTR. (2006) [Pubmed]
  14. Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives. Hong, J., Sang, S., Park, H.J., Kwon, S.J., Suh, N., Huang, M.T., Ho, C.T., Yang, C.S. Carcinogenesis (2006) [Pubmed]
  15. Terpenoids with a new skeleton and novel triterpenoids with anti-inflammatory effects from Garcinia subelliptica. Weng, J.R., Lin, C.N., Tsao, L.T., Wang, J.P. Chemistry (Weinheim an der Bergstrasse, Germany) (2003) [Pubmed]
  16. Substrate activity of structural analogs of isocitrate for isocitrate dehydrogenases from bovine heart. Plaut, G.W., Beach, R.L., Aogaichi, T. Biochemistry (1975) [Pubmed]
  17. Regioselective synthesis of the bridged tricyclic core of Garcinia natural products via intramolecular aryl acrylate cycloadditions. Tisdale, E.J., Chowdhury, C., Vong, B.G., Li, H., Theodorakis, E.A. Org. Lett. (2002) [Pubmed]
  18. Mangostin inhibits the oxidative modification of human low density lipoprotein. Williams, P., Ongsakul, M., Proudfoot, J., Croft, K., Beilin, L. Free Radic. Res. (1995) [Pubmed]
  19. Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Hayamizu, K., Hirakawa, H., Oikawa, D., Nakanishi, T., Takagi, T., Tachibana, T., Furuse, M. Fitoterapia (2003) [Pubmed]
  20. Afzeliixanthones A and B, two new prenylated xanthones from Garcinia afzelii ENGL. (Guttiferae). Kamdem Waffo, A.F., Mulholland, D., Wansi, J.D., Mbaze, L.M., Powo, R., Mpondo, T.N., Fomum, Z.T., König, W., Nkengfack, A.E. Chem. Pharm. Bull. (2006) [Pubmed]
  21. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Shara, M., Ohia, S.E., Yasmin, T., Zardetto-Smith, A., Kincaid, A., Bagchi, M., Chatterjee, A., Bagchi, D., Stohs, S.J. Mol. Cell. Biochem. (2003) [Pubmed]
  22. Determination of organic acids in leaves and rinds of Garcinia indica (Desr.) by LC. Jayaprakasha, G.K., Sakariah, K.K. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  23. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Shara, M., Ohia, S.E., Schmidt, R.E., Yasmin, T., Zardetto-Smith, A., Kincaid, A., Bagchi, M., Chatterjee, A., Bagchi, D., Stohs, S.J. Mol. Cell. Biochem. (2004) [Pubmed]
 
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