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Chemical Compound Review

Norathyriol     1,3,6,7-tetrahydroxyxanthen- 9-one

Synonyms: AC1NQYTS, CHEMBL187265, CHEBI:7622, SureCN2418732, CHEBI:411327, ...
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Disease relevance of C10086


High impact information on C10086


Chemical compound and disease context of C10086


Biological context of C10086


Anatomical context of C10086

  • 7. These data suggest that xanthone and norathyriol can induce Ca2+ release from the SR of skeletal muscle through a direct interaction with the Ca2+ release channel, also known as the ryanodine receptor [1].
  • The pharmacological effects of norathyriol on isolated rat thoracic aorta were examined [7].
  • In conclusion, norathyriol attenuates the serotonin-induced permeability of rat heart endothelial cells to macromolecules in association with inhibition of protein kinase C activation [2].
  • On the immunoblot analysis of protein kinase C subcellular distribution, the PMA-induced translocation of protein kinase C-beta from the cytosol to the membrane was not affected by norathyriol [8].

Associations of C10086 with other chemical compounds


Analytical, diagnostic and therapeutic context of C10086

  • Western blot analysis showed that norathyriol significantly inhibited the serotonin-induced translocation of the alpha protein kinase C isozyme from the cytosolic to the particulate fraction [2].


  1. Induction of calcium release from sarcoplasmic reticulum of skeletal muscle by xanthone and norathyriol. Kang, J.J., Cheng, Y.W., Ko, F.N., Kuo, M.L., Lin, C.N., Teng, C.M. Br. J. Pharmacol. (1996) [Pubmed]
  2. Decreased protein kinase C activation mediates inhibitory effect of norathyriol on serotonin-mediated endothelial permeability. Lee, H.Z., Lin, W.C., Yeh, F.T., Lin, C.N., Wu, C.H. Eur. J. Pharmacol. (1998) [Pubmed]
  3. Inhibitory effect of norathyriol, a xanthone from Tripterospermum lanceolatum, on cutaneous plasma extravasation. Wang, J.P., Raung, S.L., Lin, C.N., Teng, C.M. Eur. J. Pharmacol. (1994) [Pubmed]
  4. Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs. Teng, C.M., Ko, F.N., Wang, J.P., Lin, C.N., Wu, T.S., Chen, C.C., Huang, T.F. J. Pharm. Pharmacol. (1991) [Pubmed]
  5. Examination of the inhibitory effect of norathyriol in formylmethionyl-leucyl-phenylalanine-induced respiratory burst in rat neutrophils. Hsu, M.F., Raung, S.L., Tsao, L.T., Lin, C.N., Wang, J.P. Free Radic. Biol. Med. (1997) [Pubmed]
  6. Inhibition of the arachidonic acid cascade by norathyriol via blockade of cyclooxygenase and lipoxygenase activity in neutrophils. Hsu, M.F., Lin, C.N., Lu, M.C., Wang, J.P. Naunyn Schmiedebergs Arch. Pharmacol. (2004) [Pubmed]
  7. Vasorelaxation of rat thoracic aorta caused by norathyriol isolated from Gentianaceae. Ko, F.N., Lin, C.N., Liou, S.S., Huang, T.F., Teng, C.M. Eur. J. Pharmacol. (1991) [Pubmed]
  8. Evidence for the involvement of protein kinase C inhibition by norathyriol in the reduction of phorbol ester-induced neutrophil superoxide anion generation and aggregation. Wang, J.P., Raung, S.L., Tsao, L.T., Lin, C.N. Eur. J. Pharmacol. (1997) [Pubmed]
  9. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Wang, J.P., Ho, T.F., Lin, C.N., Teng, C.M. Naunyn Schmiedebergs Arch. Pharmacol. (1994) [Pubmed]
  10. Two proteins, Mn2+, and low molecular cofactor are required for C-glucosyl-cleavage of mangiferin. Sanugul, K., Akao, T., Nakamura, N., Hattori, M. Biol. Pharm. Bull. (2005) [Pubmed]
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