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Chemical Compound Review

ubiquinone-8     2,3-dimethoxy-5-methyl-6- [(2E,6E,10E,14E...

Synonyms: coenzyme-Q8, Ubiquinone 8, Ubiquinone 40, Ubiquinone Q8, ubiquinone(8), ...
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Disease relevance of Ubiquinone 8

  • Nonspecific resistance to bacterial infections. Enhancement by ubiquinone-8 [1].
  • The incorporation of 2H- and 13C-labelled precursors into ubiquinone-8 (Uq-8) by strains of Escherichia coli was measured in order to define the pathway for the early steps in the biosynthesis of isoprenoids in these eubacteria [2].
  • The effect of exogenous ubiquinone-8 (Q8) on IgG- and C3b-mediated phagocytosis of sensitized sheep red blood cells and of opsonized Staphylococcus aureus by macrophages was studied by morphological and quantitative methods [3].
  • The NO-2 guanine-plus-cytosine content (61.5 to 62.3 mol%) and major ubiquinone analysis (ubiquinone-8) results were both consistent with those for the genus Bordetella [4].
  • Respiratory lipoquinone and cellular fatty acid analyses showed that the type strain of P. elongata has characteristics similar to those of the genus Microbulbifer, not those of the genus PSEUDOMONAS: P. elongata DSM 6810(T) contained ubiquinone-8 as the predominant respiratory lipoquinone and iso-C(15 : 0) as the major fatty acid [5].

High impact information on Ubiquinone 8


Chemical compound and disease context of Ubiquinone 8


Biological context of Ubiquinone 8


Anatomical context of Ubiquinone 8


Associations of Ubiquinone 8 with other chemical compounds


Gene context of Ubiquinone 8


  1. Nonspecific resistance to bacterial infections. Enhancement by ubiquinone-8. Block, L.H., Georgopoulos, A., Mayer, P., Drews, J. J. Exp. Med. (1978) [Pubmed]
  2. Early steps of isoprenoid biosynthesis in Escherichia coli. Zhou, D., White, R.H. Biochem. J. (1991) [Pubmed]
  3. Ubiquinone-8 stimulates phagocytosis in macrophages by modulation of the kinetics of the Fc receptor. Block, L.H., Georgopoulos, A., Biemesderfer, D., Herzog, C., Kashgarian, M., Sitaramam, V. J. Infect. Dis. (1986) [Pubmed]
  4. Bordetella holmesii sp. nov., a new gram-negative species associated with septicemia. Weyant, R.S., Hollis, D.G., Weaver, R.E., Amin, M.F., Steigerwalt, A.G., O'Connor, S.P., Whitney, A.M., Daneshvar, M.I., Moss, C.W., Brenner, D.J. J. Clin. Microbiol. (1995) [Pubmed]
  5. Transfer of Pseudomonas elongata Humm 1946 to the genus Microbulbifer as Microbulbifer elongatus comb. nov. Yoon, J.H., Kim, H., Kang, K.H., Oh, T.K., Park, Y.H. Int. J. Syst. Evol. Microbiol. (2003) [Pubmed]
  6. Reaction of the Escherichia coli quinol oxidase cytochrome bo3 with dioxygen: the role of a bound ubiquinone molecule. Puustinen, A., Verkhovsky, M.I., Morgan, J.E., Belevich, N.P., Wikstrom, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria. Jonassen, T., Marbois, B.N., Faull, K.F., Clarke, C.F., Larsen, P.L. J. Biol. Chem. (2002) [Pubmed]
  8. Myeloperoxidase-mediated damage to the succinate oxidase system of Escherichia coli. Evidence for selective inactivation of the dehydrogenase component. Rosen, H., Rakita, R.M., Waltersdorph, A.M., Klebanoff, S.J. J. Biol. Chem. (1987) [Pubmed]
  9. Cytochrome b558 monitors the steady state redox state of the ubiquinone pool in the aerobic respiratory chain of Escherichia coli. Lorence, R.M., Carter, K., Green, G.N., Gennis, R.B. J. Biol. Chem. (1987) [Pubmed]
  10. Sulfide oxidation by gene expressions of sulfide-quinone oxidoreductase and ubiquinone-8 biosynthase in Escherichia coli. Shibata, H., Takahashi, M., Yamaguchi, I., Kobayashi, S. J. Biosci. Bioeng. (1999) [Pubmed]
  11. Kinetic studies of the lipid-activated pyruvate oxidase flavoprotein of Escherichia coli. Mather, M.W., Gennis, R.B. J. Biol. Chem. (1985) [Pubmed]
  12. Psychrobacter okhotskensis sp. nov., a lipase-producing facultative psychrophile isolated from the coast of the Okhotsk Sea. Yumoto, I., Hirota, K., Sogabe, Y., Nodasaka, Y., Yokota, Y., Hoshino, T. Int. J. Syst. Evol. Microbiol. (2003) [Pubmed]
  13. Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans. Arroyo, A., Santos-Ocaña, C., Ruiz-Ferrer, M., Padilla, S., Gavilán, A., Rodríguez-Aguilera, J.C., Navas, P. FEBS Lett. (2006) [Pubmed]
  14. Coenzyme Q homologs and vitamin E in synaptic and non-synaptic occipital cerebral cortex mitochondria in the ageing rat. Battino, M., Svegliati Baroni, S., Littarru, G.P., Bompadre, S., Leone, L., Gorini, A., Villa, R.F. Mol. Aspects Med. (1997) [Pubmed]
  15. Reconstitution of the Ubiquinone-dependent pyruvate oxidase system of Escherichia coli with the cytochrome o terminal oxidase complex. Carter, K., Gennis, R.B. J. Biol. Chem. (1985) [Pubmed]
  16. Menaquinone-specific prenyl reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus. Hemmi, H., Takahashi, Y., Shibuya, K., Nakayama, T., Nishino, T. J. Bacteriol. (2005) [Pubmed]
  17. Polaromonas naphthalenivorans sp. nov., a naphthalene-degrading bacterium from naphthalene-contaminated sediment. Jeon, C.O., Park, W., Ghiorse, W.C., Madsen, E.L. Int. J. Syst. Evol. Microbiol. (2004) [Pubmed]
  18. Biosynthesis of isoprenoids in intact cells of Escherichia coli. Fujisaki, S., Nishino, T., Katsuki, H. J. Biochem. (1986) [Pubmed]
  19. Dioxygen and temperature dependence of ubiquinone formation in Escherichia coli: studies of cells charged with 2-octaprenyl phenol. Knoell, H.E., Kraft, R., Knappe, J. Eur. J. Biochem. (1978) [Pubmed]
  20. Polyprenyl diphosphate synthase essentially defines the length of the side chain of ubiquinone. Okada, K., Suzuki, K., Kamiya, Y., Zhu, X., Fujisaki, S., Nishimura, Y., Nishino, T., Nakagawa, T., Kawamukai, M., Matsuda, H. Biochim. Biophys. Acta (1996) [Pubmed]
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