The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

TRIMETHYLTIN     trimethyltin

Synonyms: AG-E-22062, AC1NSC02, CTK4D4330, LS-186103, (CH3)3SnH, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Trimethylstannane


High impact information on Trimethylstannane

  • Macrophage-1 antigen (Mac-1) mRNA levels were lower in all op/op mice and were not induced by TMT exposure [4].
  • Reverse transcriptase polymerase chain reaction (RT-PCR) showed a TMT-induced elevation in INFalpha and INFbeta mRNA levels and no elevation of INFgamma. mRNA levels of the CSF-1 receptor, c-fms, were unaltered [4].
  • TMT-induced astrocyte reactivity was similar in both groups [4].
  • Extending these tissue culture findings in vivo, we examined the actions of N-benzylhydroxylamine in the trimethyltin (TMT) rat model of hippocampal CA3 neurodegeneration [1].
  • Significant shortening of the OHC cell body occurred at all doses to both organotins, with a mean reduction in length of 15.1 and 20.2% for 1.0 mM TMT and TET, respectively, at the end of testing; control cells were only 3.4% shorter at the end of 90 min of perfusion with bathing medium [5].

Biological context of Trimethylstannane


Anatomical context of Trimethylstannane

  • In vivo studies suggest that the initial effect of TMT on hearing occurs at the inner hair cell/spiral ganglion cell synapse, while later, the outer hair cell (OHC) undergoes structural and functional damage [5].
  • In contrast to MeHg, the structurally similar organotin trimethyltin (TMT) elicits specific apoptotic destruction of pyramidal neurons in the CA3 region of the hippocampus and in other limbic structures [3].
  • The results of the TMT linear morphometry were compared with those from stereologic counting of neurons in the cerebral cortex, piriform cortex, and hippocampus [7].

Associations of Trimethylstannane with other chemical compounds


  1. Neurotoxicity of reactive aldehydes: the concept of "aldehyde load" as demonstrated by neuroprotection with hydroxylamines. Wood, P.L., Khan, M.A., Kulow, S.R., Mahmood, S.A., Moskal, J.R. Brain Res. (2006) [Pubmed]
  2. Beneficial effects of FK506 for experimental temporal lobe epilepsy. Nishimura, T., Imai, H., Minabe, Y., Sawa, A., Kato, N. Neurosci. Res. (2006) [Pubmed]
  3. Mechanisms of injury in the central nervous system. Philbert, M.A., Billingsley, M.L., Reuhl, K.R. Toxicologic pathology. (2000) [Pubmed]
  4. Chemical-induced hippocampal neurodegeneration and elevations in TNFalpha, TNFbeta, IL-1alpha, IP-10, and MCP-1 mRNA in osteopetrotic (op/op) mice. Bruccoleri, A., Harry, G.J. J. Neurosci. Res. (2000) [Pubmed]
  5. In vitro organotin administration alters guinea pig cochlear outer hair cell shape and viability. Clerici, W.J., Chertoff, M.E., Brownell, W.E., Fechter, L.D. Toxicol. Appl. Pharmacol. (1993) [Pubmed]
  6. The cyto- and genotoxicity of organotin compounds is dependent on the cellular uptake capability. Dopp, E., Hartmann, L.M., von Recklinghausen, U., Florea, A.M., Rabieh, S., Shokouhi, B., Hirner, A.V., Obe, G., Rettenmeier, A.W. Toxicology (2007) [Pubmed]
  7. Morphometric analysis of the developing rat brain. Duffell, S.J., Soames, A.R., Gunby, S. Toxicologic pathology. (2000) [Pubmed]
  8. Chronic neonatal organotin exposure alters radial-arm maze performance in adult rats. Miller, D.B., Eckerman, D.A., Krigman, M.R., Grant, L.D. Neurobehavioral toxicology and teratology. (1982) [Pubmed]
WikiGenes - Universities