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Chemical Compound Review

Binitrobenzene     1,3-dinitrobenzene

Synonyms: Dinitrobenzene, Dwunitrobenzen, m-DNB, CHEMBL114070, NSC-7189, ...
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Disease relevance of DINITROPHENYLENE


High impact information on DINITROPHENYLENE


Chemical compound and disease context of DINITROPHENYLENE


Biological context of DINITROPHENYLENE


Anatomical context of DINITROPHENYLENE


Associations of DINITROPHENYLENE with other chemical compounds



  • GW274150 also caused a substantial reduction of (i) the degree of colon injury, (ii) the rise in myeloperoxidase (MPO) activity (mucosa), (iii) the increase in staining (immunohistochemistry) for nitrotyrosine, as well as (iv) PARP activation caused by dinitrobenzene sulfonic acid in the colon [30].
  • Here, we investigate the effects of the selective iNOS-inhibitor (S)-2-amino-(1-iminoethylamino)-5-thiopentanoic acid (GW274150) on the development of experimental colitis induced by dinitrobenzene sulfonic acid [30].
  • The present study investigates the role of regional differences in activation of the mitochondrial permeability transition pore (mtPTP) by DNB in brainstem and cortical astrocytes and examines the expression of Bcl-2 proteins as potential regulators of mtPTP function [31].
  • Increased myeloperoxidase activity was also observed in dinitrobenzene sulfonic acid-treated Sprague-Dawley rats and Flinder's Resistant Line rats [32].
  • Superoxide dismutase, glutathione peroxidase and glutathione-S-transferase (1-chloro 2, 4 dinitrobenzene) activities were also decreased in the rotavirus infected group [33].

Analytical, diagnostic and therapeutic context of DINITROPHENYLENE


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  16. Early metabolic changes during m-Dinitrobenzene neurotoxicity and the possible role of oxidative stress. Romero, I.A., Lister, T., Richards, H.K., Seville, M.P., Wylie, S.P., Ray, D.E. Free Radic. Biol. Med. (1995) [Pubmed]
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  18. Differential Expression of Genes Encoding Constitutive and Inducible 20S Proteasomal Core Subunits in the Testis and Epididymis of Theophylline- or 1,3-Dinitrobenzene-Exposed Rats. Tengowski, M.W., Feng, D., Sutovsky, M., Sutovsky, P. Biol. Reprod. (2007) [Pubmed]
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  28. Collisionally activated dissociations of aminocyclitol-aminoglycoside antibiotics and their application in the identification of a new compound in tobramycin samples. Hu, P., Chess, E.K., Brynjelsen, S., Jakubowski, G., Melchert, J., Hammond, R.B., Wilson, T.D. J. Am. Soc. Mass Spectrom. (2000) [Pubmed]
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  31. Regional variation in the activation threshold for 1,3-DNB-induced mitochondrial permeability transition in brainstem and cortical astrocytes. Tjalkens, R.B., Phelka, A.D., Philbert, M.A. Neurotoxicology (2003) [Pubmed]
  32. Cholinergic pathways modulate experimental dinitrobenzene sulfonic acid colitis in rats. Miceli, P.C., Jacobson, K. Autonomic neuroscience : basic & clinical. (2003) [Pubmed]
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  36. Germ cell apoptosis in rat testis after administration of 1,3-dinitrobenzene. Strandgaard, C., Miller, M.G. Reprod. Toxicol. (1998) [Pubmed]
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