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Chemical Compound Review

Carbicron     (E)-3-dimethoxyphosphoryloxy- N,N-dimethyl...

Synonyms: Diapadrin, Ektafos, Karbicron, Bidrin, Dicrotofos, ...
 
 
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Disease relevance of DICROTOPHOS

  • Since reactive oxygen species (ROS) are known mediators of many toxin-induced renal injuries, this study was conducted to investigate whether ROS play a role in Bidrin (BD)-induced renal tubular epithelial cell (LLC-PK1) toxicity [1].
  • A 52-year-old comatose white male was admitted to the hospital with what was later learned to be severe poisoning by a turpentine solution of dicrotophos, an organophosphorous insecticide he had ingested while drunk [2].
 

High impact information on DICROTOPHOS

 

Chemical compound and disease context of DICROTOPHOS

  • In the oral toxicity test, where N. viridula fed on food covered with insecticide residues, none of the insecticides were toxic to adults of this stink bug, but acetamiprid, dicrotophos, and thiamethoxam were moderately toxic to the nymphs [6].
 

Anatomical context of DICROTOPHOS

  • 3. The specific activity of membrane-bound phospholipase A2 and phospholipase C were decreased in both types of membranes, whereas acyl-CoA:lysophosphatidylcholine acyltransferase activity was augmented due to carbicron treatment [7].
  • 1. Treatment of rats with carbicron induced a reduction of the phospholipids in both microsomal and plasma membranes [7].
  • Teratogenic effects of two organophosphate insecticides, diazinon and dicrotophos, were investigated in regard to skeletal development, particularly of the extremities and vertebrae [8].
  • Diazinon and dicrotophos (200 micrograms/egg), injected on d 3, inhibited growth of the following skeletal elements: femur, tibia, metatarsi and digits of the leg [8].
 

Associations of DICROTOPHOS with other chemical compounds

  • Influence of carbicron (O-[(2-butenoic acid)-N,N-dimethylamide-3-yl] O,O-dimethylphosphate) on some biochemical and biophysical parameters of rat liver membranes [7].
  • In vitro studies using pralidoxime iodide up to ten times the recommended concentrations, produced insignificant reactivation of cholinesterases inhibited by the organophosphate insecticide Bidrin (di-methyl-3-hydroxyl-N, N-dimethyl-crotonamide phosphate) [9].
  • Malathion, parathion, and dicrotophos were not detected even at millimolar concentrations; however, longer exposure or prior modification of these compounds (i.e., to malaoxon, paraoxon) may increase the biosensor detection limits [10].
 

Analytical, diagnostic and therapeutic context of DICROTOPHOS

References

  1. Role of reactive oxygen metabolites in organophosphate-bidrin-induced renal tubular cytotoxicity. Poovala, V.S., Huang, H., Salahudeen, A.K. J. Am. Soc. Nephrol. (1999) [Pubmed]
  2. Severe organophosphate poisoning complicated by alcohol and turpentine ingestion. Warriner, R.A., Nies, A.S., Hayes, W.J. Arch. Environ. Health (1977) [Pubmed]
  3. Teratogenic effects of the organophosphate insecticide dicrotophos (Bidrin): histological characterization of defects. Garrison, J.C., Wyttenbach, C.R. Anat. Rec. (1985) [Pubmed]
  4. Notochordal development as influenced by the insecticide dicrotophos (Bidrin). Garrison, J.C., Wyttenbach, C.R. J. Exp. Zool. (1985) [Pubmed]
  5. Recovery of brain and plasma cholinesterase activities in ducklings exposed to organophosphorus pesticides. Fleming, W.J. Arch. Environ. Contam. Toxicol. (1981) [Pubmed]
  6. Susceptibility of pest Nezara viridula (Heteroptera: Pentatomidae) and parasitoid Trichopoda pennipes (Diptera: Tachinidae) to selected insecticides. Tillman, P.G. J. Econ. Entomol. (2006) [Pubmed]
  7. Influence of carbicron (O-[(2-butenoic acid)-N,N-dimethylamide-3-yl] O,O-dimethylphosphate) on some biochemical and biophysical parameters of rat liver membranes. Markovska, T., Koshlukova, S., Momchilova, A., Pankov, R., Yanev, E. Int. J. Biochem. (1993) [Pubmed]
  8. Teratogenic effects of cholinergic insecticides in chick embryos. III. Development of cartilage and bone. Misawa, M., Doull, J., Uyeki, E.M. Journal of toxicology and environmental health. (1982) [Pubmed]
  9. Pralidoxime as an insignificant reactivator in severe anticholinesterase (organophosphate insecticide) poisoning. Ganendran, A., Balabaskaran, S. Southeast Asian J. Trop. Med. Public Health (1976) [Pubmed]
  10. Acetylcholinesterase fiber-optic biosensor for detection of anticholinesterases. Rogers, K.R., Cao, C.J., Valdes, J.J., Eldefrawi, A.T., Eldefrawi, M.E. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1991) [Pubmed]
  11. Managing Eastern tent caterpillars Malacosoma americanum (F) on horse farms to reduce risk of mare reproductive loss syndrome. Potter, D.A., Foss, L., Baumler, R.E., Held, D.W. Pest Manag. Sci. (2005) [Pubmed]
 
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