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Chemical Compound Review

AC1NUSNF     (2S)-2-[[(2R,3S,4R,5S)-5- [(2R,3S,4S)-5-[4...

Synonyms: SureCN347387, tetrahydromethanopterin
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Disease relevance of tetrahydromethanopterin


High impact information on tetrahydromethanopterin


Chemical compound and disease context of tetrahydromethanopterin


Biological context of tetrahydromethanopterin


Associations of tetrahydromethanopterin with other chemical compounds


Gene context of tetrahydromethanopterin

  • Methods have been explored for detection of methylotrophs in natural samples, using environmental primers based on genes involved in the tetrahydromethanopterin (H4MPT)-linked C1 transfer pathway [21].

Analytical, diagnostic and therapeutic context of tetrahydromethanopterin

  • Genes for two enzymes of the tetrahydromethanopterin-linked C(1) transfer pathway (fae and fhcD) were detected in hypersaline, hyperalkaline Mono Lake (California), via PCR amplification and analysis [22].


  1. How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1. Acharya, P., Goenrich, M., Hagemeier, C.H., Demmer, U., Vorholt, J.A., Thauer, R.K., Ermler, U. J. Biol. Chem. (2005) [Pubmed]
  2. Analysis of gene islands involved in methanopterin-linked C1 transfer reactions reveals new functions and provides evolutionary insights. Kalyuzhnaya, M.G., Korotkova, N., Crowther, G., Marx, C.J., Lidstrom, M.E., Chistoserdova, L. J. Bacteriol. (2005) [Pubmed]
  3. Formaldehyde dehydrogenase preparations from Methylococcus capsulatus (Bath) comprise methanol dehydrogenase and methylene tetrahydromethanopterin dehydrogenase. Adeosun, E.K., Smith, T.J., Hoberg, A.M., Velarde, G., Ford, R., Dalton, H. Microbiology (Reading, Engl.) (2004) [Pubmed]
  4. Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii. Angelaccio, S., Chiaraluce, R., Consalvi, V., Buchenau, B., Giangiacomo, L., Bossa, F., Contestabile, R. J. Biol. Chem. (2003) [Pubmed]
  5. The role of formylmethanofuran: tetrahydromethanopterin formyltransferase in methanogenesis from carbon dioxide. Donnelly, M.I., Wolfe, R.S. J. Biol. Chem. (1986) [Pubmed]
  6. Genetic analysis of mch mutants in two Methanosarcina species demonstrates multiple roles for the methanopterin-dependent C-1 oxidation/reduction pathway and differences in H(2) metabolism between closely related species. Guss, A.M., Mukhopadhyay, B., Zhang, J.K., Metcalf, W.W. Mol. Microbiol. (2005) [Pubmed]
  7. The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes. Acharya, P., Warkentin, E., Ermler, U., Thauer, R.K., Shima, S. J. Mol. Biol. (2006) [Pubmed]
  8. Identification of a complete methane monooxygenase operon from soil by combining stable isotope probing and metagenomic analysis. Dumont, M.G., Radajewski, S.M., Miguez, C.B., McDonald, I.R., Murrell, J.C. Environ. Microbiol. (2006) [Pubmed]
  9. Formaldehyde-detoxifying role of the tetrahydromethanopterin-linked pathway in Methylobacterium extorquens AM1. Marx, C.J., Chistoserdova, L., Lidstrom, M.E. J. Bacteriol. (2003) [Pubmed]
  10. Purification of the formate-tetrahydrofolate ligase from Methylobacterium extorquens AM1 and demonstration of its requirement for methylotrophic growth. Marx, C.J., Laukel, M., Vorholt, J.A., Lidstrom, M.E. J. Bacteriol. (2003) [Pubmed]
  11. Characterization of two methanopterin biosynthesis mutants of Methylobacterium extorquens AM1 by use of a tetrahydromethanopterin bioassay. Rasche, M.E., Havemann, S.A., Rosenzvaig, M. J. Bacteriol. (2004) [Pubmed]
  12. Distribution of tetrahydromethanopterin-dependent enzymes in methylotrophic bacteria and phylogeny of methenyl tetrahydromethanopterin cyclohydrolases. Vorholt, J.A., Chistoserdova, L., Stolyar, S.M., Thauer, R.K., Lidstrom, M.E. J. Bacteriol. (1999) [Pubmed]
  13. Biochemical characterization of a dihydromethanopterin reductase involved in tetrahydromethanopterin biosynthesis in Methylobacterium extorquens AM1. Caccamo, M.A., Malone, C.S., Rasche, M.E. J. Bacteriol. (2004) [Pubmed]
  14. Generation of formate by the formyltransferase/hydrolase complex (Fhc) from Methylobacterium extorquens AM1. Pomper, B.K., Saurel, O., Milon, A., Vorholt, J.A. FEBS Lett. (2002) [Pubmed]
  15. Novel methylotrophy genes of Methylobacterium extorquens AM1 identified by using transposon mutagenesis including a putative dihydromethanopterin reductase. Marx, C.J., O'Brien, B.N., Breezee, J., Lidstrom, M.E. J. Bacteriol. (2003) [Pubmed]
  16. Why methanopterin? Comparative bioenergetics of the reactions catalyzed by methylene tetrahydrofolate reductase and methylene tetrahydromethanopterin reductase. Maden, B.E. Biochem. Soc. Trans. (1996) [Pubmed]
  17. Hydrogen-forming and coenzyme-F420-reducing methylene tetrahydromethanopterin dehydrogenase are genetically distinct enzymes in Methanobacterium thermoautotrophicum (Marburg). von Bünau, R., Zirngibl, C., Thauer, R.K., Klein, A. Eur. J. Biochem. (1991) [Pubmed]
  18. Autotrophic synthesis of activated acetic acid from CO2 in Methanobacterium thermoautotrophicum. Synthesis from tetrahydromethanopterin-bound C1 units and carbon monoxide. Länge, S., Fuchs, G. Eur. J. Biochem. (1987) [Pubmed]
  19. Investigation of serine hydroxymethyltransferase in methanogens. Lin, Z., Sparling, R. Can. J. Microbiol. (1998) [Pubmed]
  20. Methanopterin and tetrahydromethanopterin derivatives: isolation, synthesis, and identification by high-performance liquid chromatography. Keltjens, J.T., Caerteling, G.C., Vogels, G.D. Meth. Enzymol. (1986) [Pubmed]
  21. Utility of environmental primers targeting ancient enzymes: methylotroph detection in Lake Washington. Kalyuzhnaya, M.G., Lidstrom, M.E., Chistoserdova, L. Microb. Ecol. (2004) [Pubmed]
  22. Analysis of fae and fhcD genes in Mono Lake, California. Nercessian, O., Kalyuzhnaya, M.G., Joye, S.B., Lidstrom, M.E., Chistoserdova, L. Appl. Environ. Microbiol. (2005) [Pubmed]
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