Disease relevance of C12506

• EEG and SPECT 99mTc exametazime scanning failed to reveal any significant slowing or any major changes in cortical perfusion during hemiplegia as compared with nonhemiplegic periods [1].
• Technetium-99m scintigraphy: more accurate assessment of ulcerative colitis with exametazime-labelled leucocytes than with antigranulocyte antibodies [2].
• OBJECTIVE: To review clinical outcomes in patients referred for confirmation of brain death by (99m)Tc-labelled exametazime scintigraphy and to assess any tangible benefit [3].
• MATERIALS AND METHODS: A 76-year-old man who was hospitalized with fever and possible postoperative osteomyelitis underwent scintigraphic imaging with Tc-99m exametazime-labeled leukocytes [4].
• Technetium-99m exametazime brain SPECT and magnetic resonance images in the diagnosis of herpes simplex encephalitis [5].

Psychiatry related information on C12506

• Ten patients with Alzheimer-type dementia and nine age-matched normal controls were examined with SPECT, using split-dose 99mTc-labelled exametazime [6].
• Consensus development for producing diagnostic procedure guidelines: SPECT brain perfusion imaging with exametazime [7].
• Although specific patterns of technetium-99m exametazime [99mTc-hexamethylpropylene amine oxime (HMPAO)] brain single-photon emission tomography (SPET) uptake have been described for patients with dementia, no multi-institutional study has evaluated interobserver agreement [8].

High impact information on C12506

• Regional cerebral blood flow was estimated by SPECT with 99mTechnetium Exametazime in 20 patients with IDDM [9].
• DESIGN: Twenty HIV-positive subjects (12 without cognitive impairment and eight with mild cognitive impairment) and 10 HIV-negative subjects underwent neurological, neuropsychological, magnetic resonance imaging, and technetium Tc 99m exametazime SPECT examinations [10].
• Technetium-99m exametazime (99mTc-HMPAO)-labeled white blood cells: a high efficiency multidose procedure [11].
• The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18) [12].
• Applications to use exametazime as a blood pool marker in nuclear medicine are discussed [13].

Biological context of C12506

• Tc-99m exametazime-labeled leukocyte scans in the study of infections in skull neurosurgery [14].

Associations of C12506 with other chemical compounds

• MEASUREMENTS: Computed tomography and single photon emission computed tomography, with technetium Tc 99m exametazime used as a flow tracer [15].
• White blood cells were not successfully labelled with mebrofenin, disofenin, gluceptate or dimercaptosuccinic acid but were successfully labelled with exametazime, albumin colloid, sulphur colloid, sestamibi and teboroxime [16].

Analytical, diagnostic and therapeutic context of C12506

• Compared with endoscopy, sensitivity for inflammation in individual segments was 0.51 for antibody scan and 0.87 for exametazime scan; specificity was 0.67 and 0.55, respectively [2].
• Cerebral hemodynamic patterns with technetium Tc 99m exametazime single photon emission computed tomography and transcranial Doppler sonography: a validation study using visual stimulation [17].
• 99Tcm-exametazime-labelled leucocytes: effect of volume and concentration of exametazime on labelling efficiency, and clinical protocol for high efficiency multi-dose radiolabelling [18].
• The blood flow velocities were recorded using transcranial Doppler sonography, and the regional cerebral blood flow measurements were recorded with the use of technetium Tc 99m exametazime and a single photon emission computed tomographic gamma camera system [17].

References