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Chemical Compound Review

CEFPIROME     (6R,7S)-7-[[(2Z)-2-(2-amino- 1,3-thiazol-4...

Synonyms: Cefpiroma, Broact, Cefpiromum, Cerfpirome, Keiten, ...
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Disease relevance of (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-(2-azoniabicyclo[4.3.0]nona-2,4,10-trien-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


High impact information on (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-(2-azoniabicyclo[4.3.0]nona-2,4,10-trien-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Chemical compound and disease context of (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-(2-azoniabicyclo[4.3.0]nona-2,4,10-trien-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Biological context of (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-(2-azoniabicyclo[4.3.0]nona-2,4,10-trien-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Analytical, diagnostic and therapeutic context of (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-(2-azoniabicyclo[4.3.0]nona-2,4,10-trien-2-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Microanalytical high-performance liquid chromatography assay for cefpirome (HR 810) in serum [14].
  • After intravenous injection of a single dose of 2.0 g cefpirome (HR 810) and multiple doses of 2.0 g b.i.d. (11 doses) to 10 healthy male volunteers in an open design, concentrations of unchanged drug were measured at various times in serum and urine over 24 and 96 h, respectively [15].


  1. Pharmacokinetics and antibacterial efficacy of cefpirome (HR 810) in experimental Escherichia coli and Haemophilus influenzae type b meningitis. Jafari, H.S., Sáez-Llorens, X., Ramilo, O., Shelton, S.L., McCracken, G.H. Antimicrob. Agents Chemother. (1991) [Pubmed]
  2. New cephalosporins cefotaxime, cefpimizole, BMY 28142, and HR 810 in experimental pneumococcal meningitis in rabbits. Täuber, M.G., Hackbarth, C.J., Scott, K.G., Rusnak, M.G., Sande, M.A. Antimicrob. Agents Chemother. (1985) [Pubmed]
  3. Distribution of cefpirome (HR 810) to exudate in the croton oil-induced rat granuloma pouch and its therapeutic effects on experimental infections in the pouch. Arai, S., Kobayashi, S., Hayashi, S., Sakaguchi, T. Antimicrob. Agents Chemother. (1988) [Pubmed]
  4. Comparison of cefpiramide (HR-810) and four anti-pseudomonal beta-lactam agents against pseudomonas isolates from children with cystic fibrosis. Aronoff, S.C., Klinger, J.D. J. Antimicrob. Chemother. (1985) [Pubmed]
  5. Bactericidal activity of cefpirome (HR 810) against 513 gram-negative bacteria isolated from blood of septicemic patients. Bergeron, M.G., Bernier, M. Infection (1994) [Pubmed]
  6. Beta-lactamase stability of cefpirome (HR 810), a new cephalosporin with a broad antimicrobial spectrum. Kobayashi, S., Arai, S., Hayashi, S., Fujimoto, K. Antimicrob. Agents Chemother. (1986) [Pubmed]
  7. High-pressure liquid chromatographic assay and pharmacokinetics of HR 810 after intramuscular injection in rabbits. Bawdon, R.E., Lu, Y.S., Brater, D.C. Antimicrob. Agents Chemother. (1985) [Pubmed]
  8. In vitro activity of HR 810, a new cephalosporin. Bertram, M.A., Bruckner, D.A., Young, L.S. Antimicrob. Agents Chemother. (1984) [Pubmed]
  9. In-vitro activity of cefpirome (HR-810), WIN-49375, BMY-28142 and other antibiotics against nosocomially important isolates from cancer patients. Rolston, K.V., Alvarez, M.E., Hsu, K.C., Bodey, G.P. J. Antimicrob. Chemother. (1986) [Pubmed]
  10. The Antibacterial activity in vitro and beta-lactamase stability of the new cephalosporin HR 810 in comparison with five other cephalosporins and two aminoglycosides. Seibert, G., Limbert, M., Winkler, I., Dick, T. Infection (1983) [Pubmed]
  11. The in vitro activity and beta-lactamase stability of cefpirome (HR 810), a pyridine cephalosporin agent active against staphylococci, Enterobacteriaceae and Pseudomonas aeruginosa. Neu, H.C., Chin, N.X., Labthavikul, P. Infection (1985) [Pubmed]
  12. In vitro antimicrobial activity of cefpirome, a new cephalosporin with a broad antimicrobial spectrum. Arai, S., Kobayashi, S., Hayashi, S., Fujimoto, K. The Japanese journal of antibiotics. (1987) [Pubmed]
  13. Structure-activity relationships in the cefpirome (HR 810) series: synthesis and antibacterial activity of 7 alpha-methoxy and 7 alpha-formylamino analogues of HR 810. Lattrell, R., Dürckheimer, W., Kirrstetter, R., Limbert, M., Seibert, G. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1987) [Pubmed]
  14. Microanalytical high-performance liquid chromatography assay for cefpirome (HR 810) in serum. Turley, C.P., Kearns, G.L., Jacobs, R.F. Antimicrob. Agents Chemother. (1988) [Pubmed]
  15. Safety, tolerance and pharmacokinetics of 2.0 g cefpirome (HR 810) after single and multiple dosing. Badian, M., Malerczyk, V., Collins, J.D., Dixon, G.T., Verho, M., Eckert, H.G. Chemotherapy. (1988) [Pubmed]
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