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Table of contents


Chemical Compound Review

Cefpimizol     2-[1-[[(6R,7S)-2-carboxy-7- [[(2R)-2-[(5...

Synonyms: Cefpimizole, Cefpimizolum, CHEMBL2103902, AC-1370, AC1Q6LOD, ...
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Disease relevance of (6R,7R)-7-[[(2R)-2-[(5-carboxy1H-imidazole-4-carbonyl)amino]-2-phenyl-acetyl]amino]-8-oxo-3-[[4-(2-sulfoethyl)-1-pyridyl]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


High impact information on (6R,7R)-7-[[(2R)-2-[(5-carboxy1H-imidazole-4-carbonyl)amino]-2-phenyl-acetyl]amino]-8-oxo-3-[[4-(2-sulfoethyl)-1-pyridyl]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Chemical compound and disease context of (6R,7R)-7-[[(2R)-2-[(5-carboxy1H-imidazole-4-carbonyl)amino]-2-phenyl-acetyl]amino]-8-oxo-3-[[4-(2-sulfoethyl)-1-pyridyl]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Thus, for acute uncomplicated gonorrhea cefpimizole is similar in efficacy to cefotaxime and APPG but has a higher frequency of pain at the injection site [4].
  • One hundred sixteen patients (92 men and 24 women) with suspected uncomplicated gonorrhea were randomized in a double-blind manner to receive intramuscular treatment with 1.0 g of cefpimizole, 1.0 g of cefotaxime, or 4.8 x 10(6) units of aqueous procaine penicillin G (APPG) with 1 g of oral probenecid [4].

Biological context of (6R,7R)-7-[[(2R)-2-[(5-carboxy1H-imidazole-4-carbonyl)amino]-2-phenyl-acetyl]amino]-8-oxo-3-[[4-(2-sulfoethyl)-1-pyridyl]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Anatomical context of (6R,7R)-7-[[(2R)-2-[(5-carboxy1H-imidazole-4-carbonyl)amino]-2-phenyl-acetyl]amino]-8-oxo-3-[[4-(2-sulfoethyl)-1-pyridyl]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Associations of (6R,7R)-7-[[(2R)-2-[(5-carboxy1H-imidazole-4-carbonyl)amino]-2-phenyl-acetyl]amino]-8-oxo-3-[[4-(2-sulfoethyl)-1-pyridyl]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid with other chemical compounds


Gene context of (6R,7R)-7-[[(2R)-2-[(5-carboxy1H-imidazole-4-carbonyl)amino]-2-phenyl-acetyl]amino]-8-oxo-3-[[4-(2-sulfoethyl)-1-pyridyl]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


Analytical, diagnostic and therapeutic context of (6R,7R)-7-[[(2R)-2-[(5-carboxy1H-imidazole-4-carbonyl)amino]-2-phenyl-acetyl]amino]-8-oxo-3-[[4-(2-sulfoethyl)-1-pyridyl]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid


  1. Dose ranging study of cefpimizole (U-63196E) for treatment of uncomplicated gonorrhea in men. Sandberg, E.T., Pegram, P.S., Roddy, R.E., Handsfield, H.H., Hampton, K.D., Shafran, K.M., Hook, E.W. Antimicrob. Agents Chemother. (1986) [Pubmed]
  2. Comparative in vitro evaluation of cefpimizole (U-63196E), a new antipseudomonal cephalosporin. LeFrock, J.L., Smith, B.R., Bihl, J. Antimicrob. Agents Chemother. (1985) [Pubmed]
  3. Effects of AC-1370, a new semisynthetic cephalosporin, on phagocyte functions. Ohnishi, H., Kosuzume, H., Inaba, H., Okura, M., Mochizuki, H., Suzuki, Y., Fujii, R. Antimicrob. Agents Chemother. (1983) [Pubmed]
  4. Comparison of cefpimizole with cefotaxime and penicillin G for treatment of uncomplicated gonorrhea. Raad, I.I., Sherertz, R.J., Loveless, M.O., Carillo, C., O'Connor, R.P., Miller, M., Mostow, S.R. Sexually transmitted diseases. (1988) [Pubmed]
  5. Acute and subacute toxicity studies of AC-1370 sodium in mice and rats. Hashimoto, S., Ishii, H., Fujimoto, T., Tsubuku, S., Takasaki, Y. Toxicol. Lett. (1984) [Pubmed]
  6. Tolerance and disposition of cefpimizole in normal human volunteers after intramuscular administration. Novak, E., Lakings, D.B., Paxton, L.M. Antimicrob. Agents Chemother. (1987) [Pubmed]
  7. Pharmacokinetics and dose proportionality of cefpimizole in normal humans after intramuscular administration. Lakings, D.B., Novak, E., Friis, J.M., Lunan, C.M., Paxton, L.M. Antimicrob. Agents Chemother. (1986) [Pubmed]
  8. Mechanism of action of AC-1370 on phagocyte functions. Ohnishi, H., Inaba, H., Mochizuki, H., Kosuzume, H. Antimicrob. Agents Chemother. (1984) [Pubmed]
  9. Pharmacokinetics of cefpimizole in normal humans after single- and multiple-dose intravenous infusions. Lakings, D.B., Friis, J.M., Brown, R.J., Allen, H.R. Antimicrob. Agents Chemother. (1984) [Pubmed]
  10. The therapeutic efficacy of AC-1370 against experimental infections in mice. Obana, Y., Nishino, T., Tanino, T. J. Antimicrob. Chemother. (1985) [Pubmed]
  11. In vitro evaluation of U63196-E (AC-1370): antimicrobial activity, beta-lactamase stability, and beta-lactamase inhibition. Jones, R.N. Diagn. Microbiol. Infect. Dis. (1984) [Pubmed]
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