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Chemical Compound Review

Bimoclomol     1-[(chloro-pyridin-3-yl...

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Disease relevance of Bimoclomol


High impact information on Bimoclomol


Chemical compound and disease context of Bimoclomol


Biological context of Bimoclomol

  • In conclusion, bimoclomol improved cell survival in rat neonatal cardiomyocytes, in part, by increasing the levels of HSP70 [8].
  • These findings indicate that bimoclomol may be of value in targeting HSF-1 so as to induce up-regulation of protective Hsp-s in a non-stressful manner and for therapeutic benefit [9].
  • Enantioselective plasma protein binding of bimoclomol [10].
  • [Ca2+]i transients, measured under voltage clamp control, were increased in amplitude and had accelerated decay kinetics in the presence of the compound, in addition to reduction of diastolic [Ca2+]i. Bimoclomol significantly decreased the force of contraction in right ventricular trabeculae [11].
  • Enhancement of wound healing by bimoclomol was observed after thermal injury as well as following ultraviolet (UV) irradiation [12].

Anatomical context of Bimoclomol

  • 4. Bimoclomol (10 microM - 1 mM) had no significant effect on the rate of calcium uptake into sarcoplasmic reticulum vesicles of the dog, indicating that in vivo calcium reuptake might not substantially be affected by the drug [6].

Associations of Bimoclomol with other chemical compounds


Gene context of Bimoclomol


Analytical, diagnostic and therapeutic context of Bimoclomol


  1. Effect of bimoclomol (N-[2-hydroxy-3-(1-piperidinyl) propoxy]-3 pyridine-carboximidoyl-chloride) on iminodipropionitrile-induced central effects. Tóth, E., Gerevich, Z., Dóda, M., Lajtha, A. Neurochem. Int. (1998) [Pubmed]
  2. Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats. Lubbers, N.L., Polakowski, J.S., Wegner, C.D., Burke, S.E., Diaz, G.J., Daniell, K.M., Cox, B.F. Eur. J. Pharmacol. (2002) [Pubmed]
  3. Bimoclomol improves early electrophysiological signs of retinopathy in diabetic rats. Bíró, K., Pálhalmi, J., Tóth, A.J., Kukorelli, T., Juhász, G. Neuroreport (1998) [Pubmed]
  4. Bimoclomol protects against vascular consequences of experimental subarachnoid hemorrhage in rats. Erdö, F., Erdö, S.L. Brain Res. Bull. (1998) [Pubmed]
  5. Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase. Török, Z., Tsvetkova, N.M., Balogh, G., Horváth, I., Nagy, E., Pénzes, Z., Hargitai, J., Bensaude, O., Csermely, P., Crowe, J.H., Maresca, B., Vigh, L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Biphasic effect of bimoclomol on calcium handling in mammalian ventricular myocardium. Nánási, P.P., Sárközi, S., Szigeti, G., Jóna, I., Szegedi, C., Szabó, A., Bányász, T., Magyar, J., Szigligeti, P., Körtvély, A., Csernoch, L., Kovács, L., Jednákovits, A. Br. J. Pharmacol. (2000) [Pubmed]
  7. Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats. Bíró, K., Jednákovits, A., Kukorelli, T., Hegedüs, E., Korányi, L. Brain Res. Bull. (1997) [Pubmed]
  8. Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Polakowski, J.S., Wegner, C.D., Cox, B.F. Eur. J. Pharmacol. (2002) [Pubmed]
  9. Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Hargitai, J., Lewis, H., Boros, I., Rácz, T., Fiser, A., Kurucz, I., Benjamin, I., Vígh, L., Pénzes, Z., Csermely, P., Latchman, D.S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  10. Enantioselective plasma protein binding of bimoclomol. Visy, J., Fitos, I., Mády, G., Urge, L., Krajcsi, P., Simonyi, M. Chirality. (2002) [Pubmed]
  11. Effects of bimoclomol, the novel heat shock protein coinducer, in dog ventricular myocardium. Szigeti, G., Bányász, T., Magyar, J., Körtvély, A., Szigligeti, P., Kovács, L., Jednákovits, A., Nánási, P.P. Life Sci. (2000) [Pubmed]
  12. Multilateral in vivo and in vitro protective effects of the novel heat shock protein coinducer, bimoclomol: results of preclinical studies. Nánási, P.P., Jednákovits, A. Cardiovascular drug reviews. (2001) [Pubmed]
  13. Effect of subchronic bimoclomol treatment on vascular responsiveness and heat shock protein production in spontaneously hypertensive rats. Jednákovits, A., Kurucz, I., Nánási, P.P. Life Sci. (2000) [Pubmed]
  14. Electrophysiological effects of bimoclomol in canine ventricular myocytes. Magyar, J., Bányász, T., Szigligeti, P., Körtvély, A., Jednákovits, A., Nánási, P.P. Naunyn Schmiedebergs Arch. Pharmacol. (2000) [Pubmed]
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