Disease relevance of tetraethylammonium

• Renal handling of drugs in renal failure. I: Differential effects of uranyl nitrate- and glycerol-induced acute renal failure on renal excretion of TEAB and PAH in rats [1].
• Influence of steroids and stress on toxicity and disposition of tetraethylammonium bromide [2].

High impact information on tetraethylammonium

• Cimetidine, procainamide, and tetraethylammonium bromide were used in a Chinese hamster ovary model of multidrug resistance, to study handling of noncytotoxic cationic transport probes [3].
• 0. Acid-elicited responses were independent of K+, Na+, Cl-, or Ca2+ at physiological (salivary) concentrations, and were unaffected by anthracene-9-carboxylic acid, tetraethylammonium bromide, diisothiocyanate-stilbene-2,2'-disulfonic acid, vanadate, or Cd2+ [4].
• Taste receptor cells had a mean resting potential of -61.7 +/- 15 mV, a mean input resistance of 380.3 +/- 177.2 M omega, and the I-V relationship showed pronounced outward rectification; the outward rectification persisted in high-K+ saline, but was abolished by tetraethylammonium bromide (TEA) [5].
• Perfusion with perilymphs containing 0.5-15 mM of the potassium channel blocker, tetraethylammonium bromide (TEA) reduced the hair cell's frequency selectivity, whether assayed acoustically or with extrinsic currents [6].
• High threshold calcium spikes were evoked by depolarizing pulses when sodium spikes were blocked by tetrodotoxin and the potassium conductance reduced by tetraethylammonium bromide [7].

Biological context of tetraethylammonium

• All of the conjugates had a marked effect on the uptake of both the organic anion p-aminohippuric acid (PAH) and the cation tetraethylammonium bromide (TEA) into rat kidney slices, suggesting activation of the conjugates in the slices to a toxic species which interferes with ion transport [8].
• Twenty-four hours after 200 mg/kg HCBD, i.p., there was a marked decrease in the glomerular filtration rate (inulin clearance) and in the clearance of the organic anion (p-aminohippuric acid, PAH) and the organic cation (tetraethylammonium bromide, TEA) by the kidney [9].

Anatomical context of tetraethylammonium

• In one population of hair cells, tetraethylammonium bromide (TEA) blocked all outward current, leaving only an inward calcium current (ICa) [10].
• One cell facing the stratum corneum was filled with sodium benzoate solution, and the other cell facing the dermis with lithium chloride (LiCl), potassium chloride (KCl) or tetraethylammonium bromide (TEA-Br) solution [11].

Analytical, diagnostic and therapeutic context of tetraethylammonium

• Blockade of potassium conductances with extracellular iontophoresis of barium or intracellular injection of tetraethylammonium bromide could also trigger an increased degree of burst firing in DA cells [12].
• The impinger contents are analyzed by reacting the epoxy with an excess of bromide generated in situ from tetraethylammonium bromide, and measuring the unreacted bromide in the reaction mixture by normal pulse polarography [13].
• A solution of tetraethylammonium bromide is added, the fat layer is removed, and the sample is clarified by filtration and injected onto a reverse phase LC system with detection at 365 nm [14].

References