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Chemical Compound Review

Sematilide HCl     N-(2-diethylaminoethyl)-4...

Synonyms: CHEMBL553757, SureCN122585, RU-752, CK-1752, AC1Q6VTZ, ...
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Disease relevance of N-(2-diethylaminoethyl)-4-methanesulfonamido-benzamide


High impact information on N-(2-diethylaminoethyl)-4-methanesulfonamido-benzamide


Chemical compound and disease context of N-(2-diethylaminoethyl)-4-methanesulfonamido-benzamide


Biological context of N-(2-diethylaminoethyl)-4-methanesulfonamido-benzamide


Anatomical context of N-(2-diethylaminoethyl)-4-methanesulfonamido-benzamide


Associations of N-(2-diethylaminoethyl)-4-methanesulfonamido-benzamide with other chemical compounds


Gene context of N-(2-diethylaminoethyl)-4-methanesulfonamido-benzamide


Analytical, diagnostic and therapeutic context of N-(2-diethylaminoethyl)-4-methanesulfonamido-benzamide

  • After treatment with oral sematilide (mean dose, 133 +/- 29 mg every 8 hours), the patients underwent repeat 24-hour ambulatory ECG monitoring and electrophysiologic study [1].
  • Compounds 6a,d,f-k and 11 exhibited potency in the in vitro Purkinje fiber assay comparable to that of N-[2-(diethylamino)ethyl]-4- [(methylsulfonyl)amino]benzamide (1, sematilide), a potent selective class III agent which is undergoing clinical trials [15].
  • Determination of sematilide in plasma by high-performance liquid chromatography [16].
  • Separated by a 14-day washout period, the subjects received a constant rate intravenous infusion of 40 mg sematilide HCl over 30 minutes and a tablet containing 100 mg of the drug [3].
  • The goals of this retrospective study with the novel class III antiarrhythmic sematilide HCI were to investigate: a) whether there existed interspecies correlations and b) whether reliable animal-to-human predictions were possible for the main pharmacokinetics parameters [9].


  1. Antiarrhythmic effects of selective prolongation of refractoriness. Electrophysiologic actions of sematilide HCl in humans. Sager, P.T., Nademanee, K., Antimisiaris, M., Pacifico, A., Pruitt, C., Godfrey, R., Singh, B.N. Circulation (1993) [Pubmed]
  2. Hemodynamic effects of intravenous sematilide in patients with congestive heart failure: a class III antiarrhythmic agent without cardiodepressant effects. Stambler, B.S., Gottlieb, S.S., Singh, B.N., Ramanathan, K.B., Ogilby, J.D., Ellenbogen, K.A. J. Am. Coll. Cardiol. (1995) [Pubmed]
  3. Pharmacokinetics of sematilide in renal failure. Shi, J., Ripley, E., Gehr, T.W., Sica, D.A., Dandekar, K.A., Hinderling, P.H. Journal of clinical pharmacology. (1996) [Pubmed]
  4. Rate-dependent effects of sematilide on action potential duration in isolated guinea pig ventricular myocytes. Sawanobori, T., Adaniya, H., Namiki, T., Hiraoka, M. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  5. Relationship between myocardial cation content and injury in reperfused rat hearts treated with cation channel blockers. Tanonaka, K., Kajiwara, H., Kameda, H., Takasaki, A., Takeo, S. Eur. J. Pharmacol. (1999) [Pubmed]
  6. Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models. Xue, Y.X., Eto, K., Akie, Y., Hashimoto, K. Jpn. J. Pharmacol. (1996) [Pubmed]
  7. Comparison of the in vivo electrophysiological and proarrhythmic effects of amiodarone with those of a selective class III drug, sematilide, using a canine chronic atrioventricular block model. Yoshida, H., Sugiyama, A., Satoh, Y., Ishida, Y., Yoneyama, M., Kugiyama, K., Hashimoto, K. Circ. J. (2002) [Pubmed]
  8. Kinetics and dynamics of sematilide. Shi, J., Lasser, T., Koziol, T., Hinderling, P.H. Therapeutic drug monitoring. (1995) [Pubmed]
  9. Comparative kinetics of sematilide in four species. Hinderling, P.H., Dilea, C., Koziol, T., Millington, G. Drug Metab. Dispos. (1993) [Pubmed]
  10. Effects of sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes. Ishii, Y., Muraki, K., Kurihara, A., Imaizumi, Y., Watanabe, M. Eur. J. Pharmacol. (1997) [Pubmed]
  11. Cellular electrophysiological effects of the class III antiarrhythmic agents sematilide and clofilium on rabbit atrial tissues. Argentieri, T.M., Carroll, M.S., Sullivan, M.E. J. Cardiovasc. Pharmacol. (1991) [Pubmed]
  12. Rate-dependent effects of sematilide on ventricular monophasic action potential duration and delayed rectifier K+ current in rabbits. Beatch, G.N., Davis, D.R., Laganière, S., Williams, B.A. J. Cardiovasc. Pharmacol. (1996) [Pubmed]
  13. Sematilide blocks the inward rectifier potassium channel in isolated guinea pig ventricular myocytes. Takai, H., Sato, R., Katori, R. Gen. Pharmacol. (1997) [Pubmed]
  14. Effects of sematilide, a novel class III antiarrhythmic agent, on action potential in guinea pig atrium. Ishii, Y., Muraki, K., Kurihara, A., Imaizumi, Y., Watanabe, M. Jpn. J. Pharmacol. (1995) [Pubmed]
  15. Synthesis and cardiac electrophysiological activity of N-substituted-4-(1H-imidazol-1-yl)benzamides--new selective class III agents. Morgan, T.K., Lis, R., Lumma, W.C., Nickisch, K., Wohl, R.A., Phillips, G.B., Gomez, R.P., Lampe, J.W., Di Meo, S.V., Marisca, A.J. J. Med. Chem. (1990) [Pubmed]
  16. Determination of sematilide in plasma by high-performance liquid chromatography. Dancik, S., Koziol, T., Nisperos, E., Woolf, E. Journal of pharmaceutical sciences. (1991) [Pubmed]
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