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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Heart Block

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Disease relevance of Heart Block


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Chemical compound and disease context of Heart Block


Biological context of Heart Block


Anatomical context of Heart Block


Gene context of Heart Block


Analytical, diagnostic and therapeutic context of Heart Block


  1. Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Miki, T., Suzuki, M., Shibasaki, T., Uemura, H., Sato, T., Yamaguchi, K., Koseki, H., Iwanaga, T., Nakaya, H., Seino, S. Nat. Med. (2002) [Pubmed]
  2. Complete heart block with hyperthyroidism. Eraker, S.A., Wickamasekaran, R., Goldman, S. JAMA (1978) [Pubmed]
  3. Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies. Wang, D., Buyon, J.P., Zhu, W., Chan, E.K. J. Clin. Invest. (1999) [Pubmed]
  4. Complete heart block and sudden death in mice overexpressing calreticulin. Nakamura, K., Robertson, M., Liu, G., Dickie, P., Nakamura, K., Guo, J.Q., Duff, H.J., Opas, M., Kavanagh, K., Michalak, M. J. Clin. Invest. (2001) [Pubmed]
  5. Adenosine in the diagnosis of broad complex tachycardia. Griffith, M.J., Linker, N.J., Ward, D.E., Camm, A.J. Lancet (1988) [Pubmed]
  6. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Pashmforoush, M., Lu, J.T., Chen, H., Amand, T.S., Kondo, R., Pradervand, S., Evans, S.M., Clark, B., Feramisco, J.R., Giles, W., Ho, S.Y., Benson, D.W., Silberbach, M., Shou, W., Chien, K.R. Cell (2004) [Pubmed]
  7. Rheumatoid arthritis in the mother of five siblings with congenital heart block. Crittenen, I.H. N. Engl. J. Med. (1978) [Pubmed]
  8. Association of maternal systemic lupus erythematosus with congenital complete heart block. Chameides, L., Truex, R.C., Vetter, V., Rashkind, W.J., Galioto, F.M., Noonan, J.A. N. Engl. J. Med. (1977) [Pubmed]
  9. High-grade atrioventricular blocks. Phibbs, B. JAMA (1985) [Pubmed]
  10. Effect of clonidine on atrioventricular conduction. Kibler, L.E., Gazes, P.C. JAMA (1977) [Pubmed]
  11. Evidence for adenosine mediation of atrioventricular block in the ischemic canine myocardium. Belardinelli, L., Mattos, E.C., Berne, R.M. J. Clin. Invest. (1981) [Pubmed]
  12. Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. Mungrue, I.N., Gros, R., You, X., Pirani, A., Azad, A., Csont, T., Schulz, R., Butany, J., Stewart, D.J., Husain, M. J. Clin. Invest. (2002) [Pubmed]
  13. Heart block in a patient on propranolol and fluoxetine. Drake, W.M., Gordon, G.D. Lancet (1994) [Pubmed]
  14. Diltiazem and heart block. Nagle, R.E., Low-Beer, T., Horton, R. Lancet (1989) [Pubmed]
  15. First-degree atrioventricular block induced by oral cimetidine. Ishizaki, M., Yamada, Y., Kido, T., Yamaya, H., Nogawa, K., Matsui, S., Murakami, E. Lancet (1987) [Pubmed]
  16. Significance of arrhythmias during the first 24 hours of acute myocardial infarction treated with alteplase and effect of early administration of a beta-blocker or a bradycardiac agent on their incidence. Heidbüchel, H., Tack, J., Vanneste, L., Ballet, A., Ector, H., Van de Werf, F. Circulation (1994) [Pubmed]
  17. Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients. Ozols, R.F., Cunnion, R.E., Klecker, R.W., Hamilton, T.C., Ostchega, Y., Parrillo, J.E., Young, R.C. J. Clin. Oncol. (1987) [Pubmed]
  18. Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages. Miranda-Carús, M.E., Askanase, A.D., Clancy, R.M., Di Donato, F., Chou, T.M., Libera, M.R., Chan, E.K., Buyon, J.P. J. Immunol. (2000) [Pubmed]
  19. Anti-Ro/SS-A antibodies in the pathophysiology of congenital heart block in neonatal lupus syndrome, an experimental model. In vitro electrophysiologic and immunocytochemical studies. Alexander, E., Buyon, J.P., Provost, T.T., Guarnieri, T. Arthritis Rheum. (1992) [Pubmed]
  20. Cardiac contraction and intramyocardial venous pressure generation in the anaesthetized dog. Vergroesen, I., Han, Y., Goto, M., Spaan, J.A. J. Physiol. (Lond.) (1994) [Pubmed]
  21. Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block. Salomonsson, S., Sonesson, S.E., Ottosson, L., Muhallab, S., Olsson, T., Sunnerhagen, M., Kuchroo, V.K., Thorén, P., Herlenius, E., Wahren-Herlenius, M. J. Exp. Med. (2005) [Pubmed]
  22. Corrected transposition and repair of associated intracardiac defects. Westerman, G.R., Lang, P., Castaneda, A.R., Norwood, W.I. Circulation (1982) [Pubmed]
  23. Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women. Brucato, A., Frassi, M., Franceschini, F., Cimaz, R., Faden, D., Pisoni, M.P., Muscarà, M., Vignati, G., Stramba-Badiale, M., Catelli, L., Lojacono, A., Cavazzana, I., Ghirardello, A., Vescovi, F., Gambari, P.F., Doria, A., Meroni, P.L., Tincani, A. Arthritis Rheum. (2001) [Pubmed]
  24. Differential modulation of autonomic activity by ethmozin and ethacizin (analog of ethmozin) on the canine sinus node and atrioventricular junction. Urthaler, F., Rosenshtraukh, L.V., Hageman, G.R., Anjukhovsky, E.P., James, T.N. J. Am. Coll. Cardiol. (1986) [Pubmed]
  25. Outcomes of left atrial isomerism over a 28-year period at a single institution. Gilljam, T., McCrindle, B.W., Smallhorn, J.F., Williams, W.G., Freedom, R.M. J. Am. Coll. Cardiol. (2000) [Pubmed]
  26. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. Berul, C.I., Maguire, C.T., Aronovitz, M.J., Greenwood, J., Miller, C., Gehrmann, J., Housman, D., Mendelsohn, M.E., Reddy, S. J. Clin. Invest. (1999) [Pubmed]
  27. Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Hagiwara, N., Klewer, S.E., Samson, R.A., Erickson, D.T., Lyon, M.F., Brilliant, M.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  28. Cytokine polymorphisms and histologic expression in autopsy studies: contribution of TNF-alpha and TGF-beta 1 to the pathogenesis of autoimmune-associated congenital heart block. Clancy, R.M., Backer, C.B., Yin, X., Kapur, R.P., Molad, Y., Buyon, J.P. J. Immunol. (2003) [Pubmed]
  29. Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations. Lupoglazoff, J.M., Denjoy, I., Villain, E., Fressart, V., Simon, F., Bozio, A., Berthet, M., Benammar, N., Hainque, B., Guicheney, P. J. Am. Coll. Cardiol. (2004) [Pubmed]
  30. Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease. Arbustini, E., Pilotto, A., Repetto, A., Grasso, M., Negri, A., Diegoli, M., Campana, C., Scelsi, L., Baldini, E., Gavazzi, A., Tavazzi, L. J. Am. Coll. Cardiol. (2002) [Pubmed]
  31. Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. Sah, V.P., Minamisawa, S., Tam, S.P., Wu, T.H., Dorn, G.W., Ross, J., Chien, K.R., Brown, J.H. J. Clin. Invest. (1999) [Pubmed]
  32. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. Comparison of enzyme-linked immunosorbent assay and immunoblot for measurement of anti-SS-A/Ro and anti-SS-B/La antibodies. Buyon, J.P., Winchester, R.J., Slade, S.G., Arnett, F., Copel, J., Friedman, D., Lockshin, M.D. Arthritis Rheum. (1993) [Pubmed]
  33. DNA typing of maternal HLA in congenital complete heart block: comparison with systemic lupus erythematosus and primary Sjögren's syndrome. Colombo, G., Brucato, A., Coluccio, E., Compasso, S., Luzzana, C., Franceschini, F., Quinzanini, M., Scorza, R. Arthritis Rheum. (1999) [Pubmed]
  34. Comparison of ethanol septal reduction therapy with surgical myectomy for the treatment of hypertrophic obstructive cardiomyopathy. Nagueh, S.F., Ommen, S.R., Lakkis, N.M., Killip, D., Zoghbi, W.A., Schaff, H.V., Danielson, G.K., Quiñones, M.A., Tajik, A.J., Spencer, W.H. J. Am. Coll. Cardiol. (2001) [Pubmed]
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