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Chemical Compound Review

Bromfenac     sodium 2-[2-amino-3-(4...

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Disease relevance of Bromfenac


Psychiatry related information on Bromfenac


High impact information on Bromfenac


Chemical compound and disease context of Bromfenac


Biological context of Bromfenac

  • Concomitant administration of the two drugs caused an approximate 40% decrease in the mean peak plasma concentration (Cmax) and the interdose area under the concentration-time curve (AUC) of bromfenac [14].
  • Absolute bioavailability of bromfenac in humans [15].

Anatomical context of Bromfenac


Associations of Bromfenac with other chemical compounds


Gene context of Bromfenac


Analytical, diagnostic and therapeutic context of Bromfenac


  1. Analgesic efficacy of bromfenac, ibuprofen, and aspirin in postoperative oral surgery pain. Forbes, J.A., Beaver, W.T., Jones, K.F., Edquist, I.A., Gongloff, C.M., Smith, W.K., Smith, F.G., Schwartz, M.K. Clin. Pharmacol. Ther. (1992) [Pubmed]
  2. Bromfenac disposition in patients with impaired kidney function. Ermer, J.C., Boni, J.P., Cevallos, W.H., DeCleene, S., Burghart, P., Rudnick, M.R., Fruncillo, R.J., Berns, J.S., Cohen, R.M. Clin. Pharmacol. Ther. (1997) [Pubmed]
  3. Clinical pharmacokinetics and pharmacodynamics of bromfenac. Skjodt, N.M., Davies, N.M. Clinical pharmacokinetics. (1999) [Pubmed]
  4. Bromfenac, a new nonsteroidal anti-inflammatory drug: relationship between the anti-inflammatory and analgesic activity and plasma drug levels in rodents. Nolan, J.C., Osman, M.A., Cheng, L.K., Sancilio, L.F. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  5. Severe hepatotoxicity associated with bromfenac sodium. Moses, P.L., Schroeder, B., Alkhatib, O., Ferrentino, N., Suppan, T., Lidofsky, S.D. Am. J. Gastroenterol. (1999) [Pubmed]
  6. Effects of an opioid (oxycodone/paracetamol) and an NSAID (bromfenac) on driving ability, memory functioning, psychomotor performance, pupil size, and mood. Verster, J.C., Veldhuijzen, D.S., Volkerts, E.R. The Clinical journal of pain. (2006) [Pubmed]
  7. Bromfenac, acetaminophen, and placebo in orthopedic postoperative pain. McQuay, H.J., Carroll, D., Frankland, T., Harvey, M., Moore, A. Clin. Pharmacol. Ther. (1990) [Pubmed]
  8. The effect of prostaglandin synthetase inhibitors on human preovulatory follicular fluid prostaglandin, thromboxane, and leukotriene concentrations. Priddy, A.R., Killick, S.R., Elstein, M., Morris, J., Sullivan, M., Patel, L., Elder, M. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  9. Bromfenac (Duract)-associated hepatic failure requiring liver transplantation. Hunter, E.B., Johnston, P.E., Tanner, G., Pinson, C.W., Awad, J.A. Am. J. Gastroenterol. (1999) [Pubmed]
  10. A crossover comparison of bromfenac sodium, naproxen sodium, and placebo for relief of pain from primary dysmenorrhea. Mehlisch, D.R., Fulmer, R.I. Journal of women's health / the official publication of the Society for the Advancement of Women's Health Research. (1997) [Pubmed]
  11. Fatal fulminant hepatitis associated with bromfenac use. Rabkin, J.M., Smith, M.J., Orloff, S.L., Corless, C.L., Stenzel, P., Olyaei, A.J. The Annals of pharmacotherapy. (1999) [Pubmed]
  12. Acute liver failure. Fontana, R.J. Curr. Opin. Gastroenterol. (1999) [Pubmed]
  13. Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis. Miyake-Kashima, M., Takano, Y., Tanaka, M., Satake, Y., Kawakita, T., Dogru, M., Asano-Kato, N., Fukagawa, K., Fujishima, H. Jpn. J. Ophthalmol. (2004) [Pubmed]
  14. Evaluation of pharmacokinetic interaction between bromfenac and phenytoin in healthy males. Gumbhir-Shah, K., Cevallos, W.H., DeCleene, S.A., Korth-Bradley, J.M. Journal of clinical pharmacology. (1997) [Pubmed]
  15. Absolute bioavailability of bromfenac in humans. Gumbhir-Shah, K., Cevallos, W.H., DeCleene, S.A., Halstenson, C.E., Korth-Bradley, J.M. The Annals of pharmacotherapy. (1997) [Pubmed]
  16. The analgesic and antiinflammatory activity and pharmacologic properties of bromfenac. Sancilio, L.F., Nolan, J.C., Wagner, L.E., Ward, J.W. Arzneimittel-Forschung. (1987) [Pubmed]
  17. Bromfenac sodium, acetaminophen/oxycodone, ibuprofen, and placebo for relief of postoperative pain. Johnson, G.H., Van Wagoner, J.D., Brown, J., Cooper, S.A. Clinical therapeutics. (1997) [Pubmed]
  18. Lack of interaction between bromfenac and methotrexate in patients with rheumatoid arthritis. Gumbhir-Shah, K., Cevallos, W.H., DeCleene, S.A., Korth-Bradley, J.M. J. Rheumatol. (1996) [Pubmed]
  19. The effect of food on bromfenac, naproxen sodium, and acetaminophen in postoperative pain after orthopedic surgery. Forbes, J.A., Sandberg, R.A., Bood-Björklund, L. Pharmacotherapy (1998) [Pubmed]
  20. The influence of bromfenac on the pharmacokinetics and pharmacodynamic responses to glyburide in diabetic subjects. Boni, J.P., Cevallos, W.H., DeCleene, S., Korth-Bradley, J.M. Pharmacotherapy (1997) [Pubmed]
  21. Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug. Asai, T., Nakagami, T., Mochizuki, M., Hata, N., Tsuchiya, T., Hotta, Y. Cornea (2006) [Pubmed]
  22. Determination of bromfenac in plasma by high-performance liquid chromatography. Osman, M.A., Dunning, L.K., Cheng, L.K., Wright, G.J. J. Chromatogr. (1989) [Pubmed]
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