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MeSH Review


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Disease relevance of Scleritis


High impact information on Scleritis


Chemical compound and disease context of Scleritis

  • CONCLUSIONS: Although MMF maybe be useful as a steroid-sparing agent, it was not effective as an adjunctive immunosuppressive agent in patients with active scleritis in our small, tertiary referral series [8].
  • Mycophenolate mofetil was determined to be an effective steroid-sparing agent if the daily prednisone dosage could be reduced by 50% or more and was determined to be an effective adjunctive immunosuppressive agent if the scleral inflammation was controlled in patients with active scleritis [8].
  • Fluorescein angiography was found to be particularly useful in the detection of those patients who have early, but not clinically recognisable, necrotizing scleritis [9].
  • PURPOSE: Prospective evaluation of the efficacy and safety of subconjunctival triamcinolone injections for resistant, nonnecrotizing, anterior scleritis [10].
  • Patients with nodular and necrotizing scleritis were controlled with azathioprine and cyclophosphamide, respectively [11].

Biological context of Scleritis


Anatomical context of Scleritis

  • PURPOSE: To evaluate the usefulness of mycophenolate mofetil (MMF) (CellCept, Roche, Nutley, NJ), an antimetabolite immunosuppressant with a selective antiproliferative effect on T and B lymphocytes, for the treatment of scleritis [8].
  • Large cells containing prominent, refractile PAS-positive inclusions were found in cytological smears prepared from scrapings of the conjunctiva of an elderly diabetic patient with idiopathic scleritis progressing to scleromalacia perforans [13].
  • Autogenous periosteum offers advantages over other tissues as a tectonic graft for necrotizing scleritis, since it is easy to harvest and handle, it is strong and vascular, and is not subject to immunologic rejection [14].

Gene context of Scleritis


Analytical, diagnostic and therapeutic context of Scleritis


  1. Autoantibodies to inner ear and endothelial antigens in Cogan's syndrome. Lunardi, C., Bason, C., Leandri, M., Navone, R., Lestani, M., Millo, E., Benatti, U., Cilli, M., Beri, R., Corrocher, R., Puccetti, A. Lancet (2002) [Pubmed]
  2. Immunology of the eye and the joint. Zierhut, M., Feltkamp, B., Forrester, J., Saal, J., Dannecker, G. Immunol. Today (1994) [Pubmed]
  3. Autoimmune ocular disease in MRL/Mp-lpr/lpr mice is suppressed by anti-CD4 antibody. Jabs, D.A., Prendergast, R.A. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  4. Mortality rate in rheumatoid arthritis patients developing necrotizing scleritis or peripheral ulcerative keratitis. Effects of systemic immunosuppression. Foster, C.S., Forstot, S.L., Wilson, L.A. Ophthalmology (1984) [Pubmed]
  5. Use of laser flare photometry to assess and monitor inflammation in uveitis. Herbort, C.P., Guex-Crosier, Y., de Ancos, E., Pittet, N. Ophthalmology (1997) [Pubmed]
  6. Scleritis and IgA nephropathy. Nomoto, Y., Sakai, H., Endoh, M., Tomino, Y. Arch. Intern. Med. (1980) [Pubmed]
  7. Prescription-event monitoring study on 13,164 patients prescribed risedronate in primary care in England. Barrera, B.A., Wilton, L., Harris, S., Shakir, S.A. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2005) [Pubmed]
  8. Mycophenolate mofetil for the treatment of scleritis. Sen, H.N., Suhler, E.B., Al-Khatib, S.Q., Djalilian, A.R., Nussenblatt, R.B., Buggage, R.R. Ophthalmology (2003) [Pubmed]
  9. Anterior segment fluorescein angiography in the diagnosis of scleral inflammation. Watson, P.G., Bovey, E. Ophthalmology (1985) [Pubmed]
  10. A prospective evaluation of subconjunctival injection of triamcinolone acetonide for resistant anterior scleritis. Zamir, E., Read, R.W., Smith, R.E., Wang, R.C., Rao, N.A. Ophthalmology (2002) [Pubmed]
  11. Scleritis in relapsing polychondritis. Response to therapy. Hoang-Xaun, T., Foster, C.S., Rice, B.A. Ophthalmology (1990) [Pubmed]
  12. Clinical studies with a new steroid--fluorometholone. Buch, H.E., Ellis, R.A. Annals of ophthalmology. (1975) [Pubmed]
  13. Unusual intracytoplasmic inclusions in a case of idiopathic scleritis. Spinak, M., Dembitzer, H.M. Ophthalmologica (1978) [Pubmed]
  14. The treatment of necrotizing scleritis with an autogenous periosteal graft. Koenig, S.B., Kaufman, H.E. Ophthalmic surgery. (1983) [Pubmed]
  15. Expression of matrix metalloproteinases by human plasma cells and B lymphocytes. Di Girolamo, N., Tedla, N., Lloyd, A., Wakefield, D. Eur. J. Immunol. (1998) [Pubmed]
  16. Immunogenetics of episcleritis in leprosy. Joko, S., Numaga, J., Fujino, Y., Islam, S.M., Masuda, K., Maeda, H. Jpn. J. Ophthalmol. (1998) [Pubmed]
  17. High expression of interleukin-1beta in the corneal epithelium of MRL/lpr mice is under the control of their genetic background. Okamoto, M., Takagi, M., Kutsuna, M., Hara, Y., Nishihara, M., Zhang, M.C., Matsuda, T., Sakanaka, M., Okamoto, S., Nose, M., Ohashi, Y. Clin. Exp. Immunol. (2004) [Pubmed]
  18. Leukocyte adhesion molecule expression in scleritis. Sangwan, V.S., Merchant, A., Sainz de la Maza, M., Foster, C.S. Arch. Ophthalmol. (1998) [Pubmed]
  19. Celecoxib, a selective inhibitor of cyclooxygenase 2 for therapy of diffuse anterior scleritis. Bauer, A.M., Fiehn, C., Becker, M.D. Am. J. Ophthalmol. (2005) [Pubmed]
  20. Scleritis after glaucoma filtering surgery with mitomycin C. Fourman, S. Ophthalmology (1995) [Pubmed]
  21. Changes at the periphery of a lesion in necrotising scleritis: anterior segment fluorescein angiography correlated with electron microscopy. Watson, P.G., Young, R.D. The British journal of ophthalmology. (1985) [Pubmed]
  22. A randomised, double-blind trial of topical ketorolac vs artificial tears for the treatment of episcleritis. Williams, C.P., Browning, A.C., Sleep, T.J., Webber, S.K., McGill, J.I. Eye (London, England) (2005) [Pubmed]
  23. Corneal complications after cataract surgery in patients with rheumatoid arthritis. Jones, R.R., Maguire, L.J. Cornea (1992) [Pubmed]
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