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Chemical Compound Review

CTK8I0335     1$l^{3}-stannacyclohexa- 1,3,5-triene

Synonyms: AC1O3S5R
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Disease relevance of Stannin


High impact information on Stannin


Chemical compound and disease context of Stannin

  • Based on current findings, we suggest that stannin expression is necessary but not sufficient for TMT toxicity [3].

Biological context of Stannin


Anatomical context of Stannin


Associations of Stannin with other chemical compounds


Gene context of Stannin


Analytical, diagnostic and therapeutic context of Stannin

  • High stringency Southern blot analysis of genomic DNA identified stannin homologs in rabbit, Drosophila, and human [1].


  1. Molecular neurotoxicology of trimethyltin: identification of stannin, a novel protein expressed in trimethyltin-sensitive cells. Toggas, S.M., Krady, J.K., Billingsley, M.L. Mol. Pharmacol. (1992) [Pubmed]
  2. Induction of apoptosis by organotin compounds in vitro: neuronal protection with antisense oligonucleotides directed against stannin. Thompson, T.A., Lewis, J.M., Dejneka, N.S., Severs, W.B., Polavarapu, R., Billingsley, M.L. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  3. Localization and characterization of stannin: relationship to cellular sensitivity to organotin compounds. Dejneka, N.S., Patanow, C.M., Polavarapu, R., Toggas, S.M., Krady, J.K., Billingsley, M.L. Neurochem. Int. (1997) [Pubmed]
  4. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. Horrevoets, A.J., Fontijn, R.D., van Zonneveld, A.J., de Vries, C.J., ten Cate, J.W., Pannekoek, H. Blood (1999) [Pubmed]
  5. Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride. Buck-Koehntop, B.A., Mascioni, A., Buffy, J.J., Veglia, G. J. Mol. Biol. (2005) [Pubmed]
  6. Stannin, a protein that localizes to the mitochondria and sensitizes NIH-3T3 cells to trimethyltin and dimethyltin toxicity. Davidson, C.E., Reese, B.E., Billingsley, M.L., Yun, J.K. Mol. Pharmacol. (2004) [Pubmed]
  7. Protein kinase C epsilon regulates tumor necrosis factor-alpha-induced stannin gene expression. Reese, B.E., Davidson, C., Billingsley, M.L., Yun, J. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  8. Elucidation of stannin function using microarray analysis: implications for cell cycle control. Reese, B.E., Krissinger, D., Yun, J.K., Billingsley, M.L. Gene Expr. (2006) [Pubmed]
  9. Chromosomal localization and characterization of the stannin (Snn) gene. Dejneka, N.S., Polavarapu, R., Deng, X., Martin-DeLeon, P.A., Billingsley, M.L. Mamm. Genome (1998) [Pubmed]
  10. Alterations in hippocampal expression of SNAP-25, GAP-43, stannin and glial fibrillary acidic protein following mechanical and trimethyltin-induced injury in the rat. Patanow, C.M., Day, J.R., Billingsley, M.L. Neuroscience (1997) [Pubmed]
  11. The protein stannin binds 14-3-3zeta and modulates mitogen-activated protein kinase signaling. Davidson, C.E., Reese, B.E., Billingsley, M.L., Yun, J.K. Brain Res. Mol. Brain Res. (2005) [Pubmed]
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