Disease relevance of Stannin

• These findings indicate that stannin is present in TMT-sensitive cells and may play a role in the selective toxicity of organotin compounds [1].
• Stannin was absent in the resistant HTB-14 glioma cell line [2].
• Stannin was also expressed in a baculovirus system, using a series of constructs containing the entire cDNA, 1.0 kb of DNA flanking the open reading frame, and a 400 bp open reading frame minimal construct [3].

High impact information on Stannin

• Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes [4].
• Stannin (SNN), an 88-residue mitochondrial membrane protein, has been identified as the specific marker for neuronal cell apoptosis induced by TMT intoxication [5].
• Stannin (Snn) is a highly conserved, 88-amino acid protein that may mediate the selective toxicity of organotins [6].
• In situ hybridization in human hippocampus demonstrated a stannin mRNA in pyramidal and dentate gyrus neurons [1].
• This 2.9-kilobase cDNA encodes a putative 10-kDa peptide of 88 amino acids, termed "stannin." In immunocytochemical experiments, antisera raised against the amino terminus of stannin exhibited strong immunoreactivity in TMT-sensitive neurons in the hippocampus and entorhinal cortex, areas previously identified by in situ hybridization [1].

Chemical compound and disease context of Stannin

• Based on current findings, we suggest that stannin expression is necessary but not sufficient for TMT toxicity [3].

Biological context of Stannin

• Protein kinase C epsilon regulates tumor necrosis factor-alpha-induced stannin gene expression [7].
• Elucidation of stannin function using microarray analysis: implications for cell cycle control [8].
• In this study, we have isolated a mouse stannin genomic clone and have characterized the gene's intron-exon organization, promoter region, and chromosomal location [9].
• Fluorescence in situ hybridization analysis localized stannin to mouse Chromosome (Chr) 16 at band A2 [9].

Anatomical context of Stannin

• Northern blot and in situ hybridization experiments detected a 3.0-kilobase stannin mRNA in brain, spleen, and kidney; expression occurred as early as embryonic day 15 in rat brain and thymus [1].
• Liver, heart, skeletal muscle and testis showed no detectable expression of stannin mRNA [3].
• Northern blot analysis showed that the stannin 3.0 kb mRNA transcript was present, in decreasing amounts, in: spleen, hippocampus, neocortex, cerebellum, striatum, midbrain, kidney and lung [3].

Associations of Stannin with other chemical compounds

• Thus, TMT may induce apoptosis in sensitive cells, which is partly mediated by stannin [2].
• Alterations in hippocampal expression of SNAP-25, GAP-43, stannin and glial fibrillary acidic protein following mechanical and trimethyltin-induced injury in the rat [10].

Gene context of Stannin

• The protein stannin binds 14-3-3zeta and modulates mitogen-activated protein kinase signaling [11].

Analytical, diagnostic and therapeutic context of Stannin

• High stringency Southern blot analysis of genomic DNA identified stannin homologs in rabbit, Drosophila, and human [1].

References