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Chemical Compound Review

MCYST-RR     (5R,8S,11R,12S,15S,18R,19S,22R )-8,15-bis[3...

Synonyms: microcystin RR, AC1O5PJE, LS-182802, C19995, 111755-37-4, ...
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Disease relevance of microcystin RR


Psychiatry related information on microcystin RR

  • The operating parameters such as hydrogen peroxide dosage, pH value, UV light intensity, initial concentration of microcystin-RR and reaction time were evaluated, respectively [6].

High impact information on microcystin RR


Biological context of microcystin RR


Anatomical context of microcystin RR


Associations of microcystin RR with other chemical compounds

  • The most sensitive single-chain antibody (scAb) isolated was capable of detecting microcystin-LR at levels below the World Health Organization limit in drinking water (1 microg liter(-1)) and cross-reacted with three other purified microcystin variants (microcystin-RR, -LW, and -LF) and the related cyanotoxin nodularin [16].

Gene context of microcystin RR


Analytical, diagnostic and therapeutic context of microcystin RR


  1. A LC/MS method for the determination of cyanobacteria toxins in water. Maizels, M., Budde, W.L. Anal. Chem. (2004) [Pubmed]
  2. The solution NMR structure of a blue-green algae hepatotoxin, microcystin-RR--a comparison with the structure of microcystin-LR. Trogen, G.B., Edlund, U., Larsson, G., Sethson, I. Eur. J. Biochem. (1998) [Pubmed]
  3. Physiological and biochemical analyses of microcystin-RR toxicity to the cyanobacterium Synechococcus elongatus. Hu, Z.Q., Liu, Y.D., Li, D.H. Environ. Toxicol. (2004) [Pubmed]
  4. Detection and quantification of microcystins (cyanobacterial hepatotoxins) with recombinant antibody fragments isolated from a naïve human phage display library. McElhiney, J., Lawton, L.A., Porter, A.J. FEMS Microbiol. Lett. (2000) [Pubmed]
  5. Oral exposure to Microcystis increases activity-augmented antioxidant enzymes in the liver of loach (Misgurnus mizolepis) and has no effect on lipid peroxidation. Li, X.Y., Chung, I.K., Kim, J.I., Lee, J.A. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2005) [Pubmed]
  6. Degradation of microcystin-RR by UV radiation in the presence of hydrogen peroxide. Qiao, R.P., Li, N., Qi, X.H., Wang, Q.S., Zhuang, Y.Y. Toxicon (2005) [Pubmed]
  7. Changes in the metaphase transit times and the pattern of sister chromatid separation in stamen hair cells of Tradescantia after treatment with protein phosphatase inhibitors. Wolniak, S.M., Larsen, P.M. J. Cell. Sci. (1992) [Pubmed]
  8. Microcystin-RR-induced apoptosis in tobacco BY-2 cells. Yin, L., Huang, J., Li, W., Liu, Y. Toxicon (2006) [Pubmed]
  9. Differential detoxification and antioxidant response in diverse organs of Corydoras paleatus experimentally exposed to microcystin-RR. Cazenave, J., Bistoni, M.d.e. .L., Pesce, S.F., Wunderlin, D.A. Aquat. Toxicol. (2006) [Pubmed]
  10. Responses of antioxidant system in Arabidopsis thaliana suspension cells to the toxicity of microcystin-RR. Yin, L., Huang, J., Huang, W., Li, D., Liu, Y. Toxicon (2005) [Pubmed]
  11. Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis. A field and laboratory study. Cazenave, J., Wunderlin, D.A., de Los Angeles Bistoni, M., Amé, M.V., Krause, E., Pflugmacher, S., Wiegand, C. Aquat. Toxicol. (2005) [Pubmed]
  12. Microcystin-RR-induced accumulation of reactive oxygen species and alteration of antioxidant systems in tobacco BY-2 cells. Yin, L., Huang, J., Huang, W., Li, D., Wang, G., Liu, Y. Toxicon (2005) [Pubmed]
  13. Microcystin uptake inhibits growth and protein phosphatase activity in mustard (Sinapis alba L.) seedlings. Kurki-Helasmo, K., Meriluoto, J. Toxicon (1998) [Pubmed]
  14. Microcystin-RR uptake and its effects on the growth of submerged macrophyte Vallisneria natans (lour.) hara. Yin, L., Huang, J., Li, D., Liu, Y. Environ. Toxicol. (2005) [Pubmed]
  15. Quail spleen is enlarged by microcystin RR as a blue-green algal hepatotoxin. Takahashi, S., Kaya, K. Nat. Toxins (1993) [Pubmed]
  16. Rapid isolation of a single-chain antibody against the cyanobacterial toxin microcystin-LR by phage display and its use in the immunoaffinity concentration of microcystins from water. McElhiney, J., Drever, M., Lawton, L.A., Porter, A.J. Appl. Environ. Microbiol. (2002) [Pubmed]
  17. Identification of microcystin-RR and [Dha7]microcystin-RR in commercial standards by electrospray ionization mass spectrometry. Kubwabo, C., Vais, N., Benoit, F.M. Journal of AOAC International. (2004) [Pubmed]
  18. Generation of antibodies directed against the low-immunogenic peptide-toxins microcystin-LR/RR and nodularin. Baier, W., Loleit, M., Fischer, B., Jung, G., Neumann, U., Weiss, M., Weckesser, J., Hoffmann, P., Bessler, W.G., Mittenbühler, K. Int. J. Immunopharmacol. (2000) [Pubmed]
  19. Microcystins in Slovene freshwaters (central Europe)--first report. Sedmak, B., Kosi, G. Nat. Toxins (1997) [Pubmed]
  20. Degradation of microcystins using immobilized microorganism isolated in an eutrophic lake. Tsuji, K., Asakawa, M., Anzai, Y., Sumino, T., Harada, K. Chemosphere (2006) [Pubmed]
  21. High grazer toxicity of [D-Asp(3),(E)-Dhb(7)]microcystin-RR of Planktothrix rubescens as compared to different microcystins. Blom, J.F., Robinson, J.A., Jüttner, F. Toxicon (2001) [Pubmed]
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