Disease relevance of TETRAETHYL LEAD

• These include intoxications with bismuth, methyl bromide, cooking oil containing anilines, and tetraethyl lead [1].
• Tetraethyl lead contributed to the toxicity of the leaded fractions [2].
• He had no symptoms or physical signs of lead poisoning and comparisons are made between this case and previously reported cases of poisoning by tetraethyl lead [3].

Psychiatry related information on TETRAETHYL LEAD

• Effect of tetraethyl lead and restricted food intake on locomotor activity in the rat [4].

High impact information on TETRAETHYL LEAD

• Following acute tetraethyllead intoxication in rabbits classic neurofibrillary tangles develop [5].
• Triethyllead (TEL), the active metabolite of tetraethyllead, was shown previously to inhibit selectively high-affinity Na+-dependent uptake of gamma-aminobutyric acid (GABA) into cerebrocortical synaptosomes [6].
• Erythrocytic ALAD activity was used as a screening test for the detection of tetraethyl lead (TEL) poisoning in a group of 43 children who were presumed gasoline sniffers [7].
• The triethyllead concentration in the circulating water accounted for 60-80% of the maximal amount, that could be formed from tetraethyllead by a single dealkylation [8].
• Tetraethyl lead was still in use as an antiknock agent in Paris during the sampling period of the study, while it has been replaced by methylcyclopentadienyl manganese tricarbonyl (MMT) in Canada since 1977 [9].

Chemical compound and disease context of TETRAETHYL LEAD

• Dependent on the level of occupational exposure to tetraethyl lead, the occurrence of early signs of toxicity and the urinary excretion of triethyl lead, diethyl lead and total lead compounds were investigated [10].

Biological context of TETRAETHYL LEAD

• Metabolism of tetraorganolead compounds by rat-liver microsomal mono-oxygenase. II. Enzymic dealkylation of tetraethyl lead [11].
• Effect of tetraethyl lead on food and water intake in the rat [12].
• Biological monitoring of lead in workers exposed to tetraethyllead [13].
• After the 1920s, environmental pollution by lead caused by the introduction of tetraethyl lead in gasoline became an alarming public health problem [14].
• On the toxic effects of tetraethyl lead and its derivatives on the chrysophyte Poterioochromonas malhamensis. VI. Effects on lorica formation, mitosis, and cytokinesis [15].

Anatomical context of TETRAETHYL LEAD

• The biological degradation of tetraethyl lead to the triethyl lead cation by rat-liver microsomes from untreated, phenobarbital-pretreated and methylcholanthrene-pretreated rats has been studied; NADPH and oxygen are essential [11].

Associations of TETRAETHYL LEAD with other chemical compounds

• Effects of tetraethyl lead (TEL) and derivatives triethyl lead (TriEL), diethyl lead (DiEL), and inorganic lead (Pb) on lorica formation of the unicellular alga Poterioochromonas malhamensis were investigated by light and electron microscopy [15].
• The volatile lead species PbEt4 was derivatized from NIST isotopic certified lead standard SRM 981 and different amounts of PbEt4 dissolved in iso-octane were injected into the GC [16].
• Diethyllead as a specific indicator of occupational exposure to tetraethyllead [17].

Gene context of TETRAETHYL LEAD

• The transplacental effect of lead compounds (lead acetate and tetraethyl lead) on the tissue plasminogen activator activity (PAA), plasminogen activator inhibition (PAI) and plasmin inhibition (PI) was studied in the rat [18].

Analytical, diagnostic and therapeutic context of TETRAETHYL LEAD

• Case-control study of cancer risk in tetraethyl lead manufacturing [19].
• CONCLUSIONS: The elimination of tetraethyl lead from petrol resulted in a significant decrease in hospitalization of petrol sniffers [20].

References