Disease relevance of triethyllead

• Influence of triethyl lead on the activity of enzymes of the ascites tumor cell plasma membrane and its microviscosity [1].
• The influence of triethyl lead (TriEL) on the activity of plasma membrane-bound enzymes of Ehrlich ascites tumor cells and on membrane fluidity has been investigated [1].
• Subchronic oral toxicity of triethyl lead in the male weanling rat. Clinical, biochemical, hematological, and histopathological effects [2].

Psychiatry related information on triethyllead

• These data suggest that acute exposure to triethyl lead enhances the responsiveness of dopaminergic processes which contribute to locomotor activity [3].

High impact information on triethyllead

• Treatment of rats with triethyl lead caused diminished reactions of the antibodies against Yb1 and Yp GSTs and increased reactions of anti-Ya with its retinal targets, whereas the total GST activity did not change significantly [4].
• The interaction of triethyl lead with tubulin and microtubules [5].
• This enhanced sensitivity to dopaminergic agonists was not due to altered pharmacokinetics of the challenge drugs, since the onset and duration of their behavioral effects were not affected by triethyl lead [3].
• Methyl mercury (IC50 0.9 microM) and triethyl lead (IC50 2.6 microM) inhibited binding as well [6].
• This suggests that although the total number of glia may return to normal the number of each type of glial cell present changes following injection of triethyl lead [7].

Biological context of triethyllead

• On postpartum day 5, pups were administered either 12, 13, 14, or 15 mg/kg TEL, with each design represented by 12 litters [8].
• Tetraethyl lead and triethyl lead inhibit cytokinesis of the chrysophycean flagellate Poterioochromonas [9].
• The increased heat production rate was accompanied by degradation of Et4Pb, as verified by speciation analysis (GC-MS) of the remaining Et4Pb and its ionic degradation products (triethyl lead and diethyl lead cations) [10].
• Assessment of developmental consequences due to triethyl lead (TEL) intoxication presently included (1) determination of the acute LD50 as 13 +/- 1 mg/kg, and (2) detailed examination of early neurobehavioral sequelae [11].

Anatomical context of triethyllead

• Although changes in more than one factor may account for the antinociceptive effect of triethyl lead, the hippocampus seems especially vulnerable to this amphiphilic organometal [12].
• Triethyl lead has been shown to disrupt cytoskeletal elements, particularly neurofilaments, at very low levels, suggesting a possible mechanism for its inhibition of neurite branching at nanomolar concentrations [13].
• Apparent Km values for triethyl lead formation in microsomes were determined [14].
• In the concentration range 12 to 30 microM, triethyl lead disturbed normal development of the algae, caused changed dictyosomal ultrastructure, disturbed the formation of the secondary cell wall, and caused accumulation of lipid material [15].
• Furthermore, Ishikawa cells treated with 10(-5) M triethyl lead and stained with anti-HSP90 antibodies demonstrated residual filamentous structures, clearly different from those of reorganized vimentin intermediate filaments [16].

Associations of triethyllead with other chemical compounds

• Effect of triethyl lead on the placental uptake and transfer of the non-metabolisable alpha-aminoisobutyric acid in guinea pigs [17].
• Effects of triethyl lead administration on the expression of glutathione S-transferase isoenzymes and quinone reductase in rat kidney and liver [18].
• All antidotes markedly increased inhibition of algal growth caused by triethyl lead and some were even lethal to the poisoned algae either at the highest (Na2EDTA, EDTA, DPA) or at all concentrations used (DIZO, BAL) [19].
• Kinetic parameters of the inhibition of red blood cell aminolevulinic acid dehydratase by triethyl lead and its reversal by dithiothreitol and zinc [20].
• Progesterone and oestrogen concentrations in plasma during blastocyst implantation in mice exposed to triethyl lead [21].

Gene context of triethyllead

• M triethyl lead and double stained with anti-HSP90 and anti-vimentin antibodies demonstrated clearly different filamentous patterns, when exposed on the same photographic plaque.(ABSTRACT TRUNCATED AT 250 WORDS)[16]

Analytical, diagnostic and therapeutic context of triethyllead

• Developing cells of three strains of the desmidiacean alga Micrasterias were treated with inorganic and triethyl lead and examined by light and electron microscopy [15].
• Using conventional two electrode voltage clamp techniques we have studied the effects of Pb2+, triethyl lead (TEL) and Hg2+ on voltage-activated calcium channels of Aplysia neurons and found that all three metals are potent inhibitors at micromolar concentrations [22].
• It was found that triethyl lead treatment (2.5 mg/kg body wt) decreased the AIB-concentration in perfusion media compared with that of the control group [17].
• After dosing with triethyl lead, in vivo inhibition of ALAD only occurred at the high dose, but activation analysis in vitro showed increased ALAD activity to be present at all dose levels in a dose-dependent fashion [20].

References