The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

GRISELIMYCINE     4-methoxy-2-methyl-1,3- dinitro-5-tert...

Synonyms: Ambrette musk, MUSK AMBRETTE, Amber musk, CCRIS 2390, AG-J-28172, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LS-1827


High impact information on LS-1827

  • Lymphocytes from naive mice or mice photosensitized with musk ambrette (MA) demonstrated a significantly lower response to LC-EC modified with TCSA + UVA, indicating the specificity of the response [6].
  • This study reports the induction of contact photodermatitis to musk ambrette, 2-methoxy-3,5-dinitro-4-methyl-t-butylbenzene, in guinea pigs [2].
  • Phtotoxicity tests to musk ambrette at concentrations between 1 and 50% and a dose of 10.2 joules/cm2 from "Black Light" fluorescent tubes were all negative [2].
  • Musk ambrette (2,6-dinitro-3-methoxy-4-tert-butyltoluene), a nitro-musk compound widely used as a fixative in fragrance formulations and found to a lesser degree in flavor compositions, produces hindlimb weakness when administered in the diet or applied to skin of rats for periods up to 12 weeks [7].
  • To clarify the role of bacterial nitroreductases (NR) in the toxification of musk ambrette to mutagenic metabolites the compound was examined with the Salmonella/mammalian microsome assay using the NR deficient strain S.typhimurium TA 100 NR in the presence and absence of S9 [5].

Chemical compound and disease context of LS-1827


Biological context of LS-1827

  • Musk ambrette showed mutagenicity in Salmonella typhimurium TA 100 requiring metabolic activation by rat liver postmitochondrial supernatant (S9) but it lacked mutagenicity in the absence of S9 and genotoxicity in the SOS chromotest [11].

Anatomical context of LS-1827


Associations of LS-1827 with other chemical compounds


Analytical, diagnostic and therapeutic context of LS-1827


  1. Current status of predictive animal models for drug photoallergy and their correlation with drug photoallergy in humans. Harber, L.C., Armstrong, R.B., Ichikawa, H. J. Natl. Cancer Inst. (1982) [Pubmed]
  2. Assay of contact photosensitivity to musk ambrette in guinea pigs. Kochever, I.E., Zalar, G.L., Einbinder, J., Harber, L.C. J. Invest. Dermatol. (1979) [Pubmed]
  3. Contact and photocontact allergy to musk ambrette. Wojnarowska, F., Calnan, C.D. Br. J. Dermatol. (1986) [Pubmed]
  4. Persistent photosensitivity caused by musk ambrette. Zugerman, C. Archives of dermatology. (1981) [Pubmed]
  5. Salmonella mutagenicity of musk ambrette depends on both microsomal and bacterial enzyme activity. Mersch-Sundermann, V., Emig, M. Anticancer Res. (1998) [Pubmed]
  6. Examination of tetrachlorosalicylanilide (TCSA) photoallergy using in vitro photohapten-modified Langerhans cell-enriched epidermal cells. Gerberick, G.F., Ryan, C.A., Von Bargen, E.C., Stuard, S.B., Ridder, G.M. J. Invest. Dermatol. (1991) [Pubmed]
  7. Neurotoxic properties of musk ambrette. Spencer, P.S., Bischoff-Fenton, M.C., Moreno, O.M., Opdyke, D.L., Ford, R.A. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
  8. A predictive mouse ear-swelling model for investigating topical photoallergy. Gerberick, G.F., Ryan, C.A. Food Chem. Toxicol. (1990) [Pubmed]
  9. Patch and photopatch testing in chronic actinic dermatitis. Barber, K.A., Cronin, E. Contact Derm. (1984) [Pubmed]
  10. Perfume dermatitis. Part II. Photodermatitis to Musk Ambrette and 6-methylcoumarin. Fisher, A.A. Cutis; cutaneous medicine for the practitioner. (1980) [Pubmed]
  11. A comparative study of five nitro musk compounds for genotoxicity in the SOS chromotest and Salmonella mutagenicity. Emig, M., Reinhardt, A., Mersch-Sundermann, V. Toxicol. Lett. (1996) [Pubmed]
  12. Airborne pigmented contact dermatitis due to musk ambrette in incense. Hayakawa, R., Matsunaga, K., Arima, Y. Contact Derm. (1987) [Pubmed]
  13. A simple method of qualitative analysis for musk ambrette, musk ketone and musk xylene in cologne. Goh, C.L., Kwok, S.F. Contact Derm. (1986) [Pubmed]
  14. The guinea pig as a model for predicting photoallergic contact dermatitis. Jordan, W.P. Contact Derm. (1982) [Pubmed]
  15. Identification, occurrence and mutagenicity in Salmonella typhimurium of two synthetic nitroarenes, musk ambrette and musk xylene, in Indian chewing tobacco and betel quid. Nair, J., Ohshima, H., Malaveille, C., Friesen, M., O'Neill, I.K., Hautefeuille, A., Bartsch, H. Food Chem. Toxicol. (1986) [Pubmed]
  16. Thin layer chromatography and high pressure liquid chromatography of musk ambrette and other nitromusk compounds including photopatch studies. Bruze, M., Edman, B., Niklasson, B., Möller, H. Photo-dermatology. (1985) [Pubmed]
  17. Photosensitivity to musk ambrette. Cronin, E. Contact Derm. (1984) [Pubmed]
  18. Determination of musk ambrette in fragrance products by capillary gas chromatography with electron capture detection: interlaboratory study. Wisneski, H.H., Yates, R.L., Havery, D.C. Journal of AOAC International. (1994) [Pubmed]
  19. Phototoxicity, photoallergy, and contact sensitization of nitro musk perfume raw materials. Parker, R.D., Buehler, E.V., Newmann, E.A. Contact Derm. (1986) [Pubmed]
WikiGenes - Universities