Disease relevance of sodium picosulfate

• Sodium picosulfate in opioid-induced constipation: results of an open-label, prospective, dose-ranging study [1].
• The frequency of headache after Picolax (sodium picosulphate, Nordic Ltd) preparation for barium enema was investigated and its association with dehydration, as assessed by haemoconcentration, was determined [2].
• Shaoyao-Gancao-Tang (SGT), a traditional Chinese formulation composed of Shaoyao (Paeoniae Radix) and Gancao (Glycyrrhizae Radix), is frequently used in conjunction with laxatives such as sodium picosulfate in colonoscopy to relieve abdominal pains [3].
• Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man [4].
• Safety of Picolax (sodium picosulphate-magnesium citrate) in inflammatory bowel disease [5].

High impact information on sodium picosulfate

• Fifty-nine consecutive patients admitted for colonoscopy were randomized to receive polyethylene glycol or sodium picosulphate [6].
• This effect occurred within 1 h after oral administration, mostly within 30 min, whereas sodium picosulfate, a widely used laxative, tended to increase the frequency of defecation for several hours with much lower peak incidence than that of YM-31636, and induced diarrhea [7].
• CONCLUSIONS: Chronic treatment with anthranoids in high doses, but not with sodium picosulphate, reduces VIP and somatostatin levels in the rat colon [8].
• Sodium picosulphate: reaction or drug interaction [9]?
• Sodium picosulfate, a laxative, was biotransformed to 4,4'-dihydroxydiphenyl-(2 pyridyl)-methane by intestinal flora that produced a novel sulfotransferase (not sulfatase) [10].

Biological context of sodium picosulfate

• Because of an early and reliable onset of action compared with sodium picosulfate, YM-31636 could make it easier to control the time of defecation [7].
• Randomized trial of oral sodium phosphate compared with oral sodium picosulphate (Picolax) for elective colorectal surgery and colonoscopy [11].

Anatomical context of sodium picosulfate

• The effect of sodium picosulfate was examined in liver cell cultures of rabbit, rat and man exposed to substance concentrations of 25, 50, 100, 200, 400, 800 and 1600 micrograms/ml [4].

Associations of sodium picosulfate with other chemical compounds

• Audit of bowel preparation with Picolax (sodium picosulfate plus magnesium citrate) for colonoscopy [12].
• The protein content was lowered in liver cells of rabbit exposed to 1600 micrograms/ml sodium picosulfate and the human cells exposed to 100 micrograms/ml bisacodyl [13].
• Cytotoxic effects were studied in Chang liver cells exposed to 4,4'-dihydroxy-diphenyl-(2-pyridyl)-methane-bis(hydrogen sulfate) (ether)-disodium salt (sodium picosulfate) and the results were compared with the effects of other laxatives [14].

Analytical, diagnostic and therapeutic context of sodium picosulfate

• If a limited colonoscopy or flexible sigmoidoscopy is intended, sodium picosulphate may be preferred because of its acceptable efficacy and slightly advantageous side-effect profile [6].
• There was no clear relationship between the opioid dose and the optimum dose of sodium picosulfate, confirming that individual dose titration is necessary [1].
• Retrospective study of long-term treatment with sodium picosulfate [15].
• A randomized prospective trial was undertaken to compare the relative effectiveness of two commonly used bowel preparations (senna tablets and sodium picosulphate powder) administered to patients before they underwent out-patient intravenous urography [16].
• Because neither lavage solution displayed a marked advantage for the colonoscopist or radiologist, and sodium picosulphate was more acceptable to patients, sodium picosulphate is the preferred solution for bowel preparation [17].

References