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Chemical Compound Review

Dulcolax     [4-[(4-acetyloxyphenyl)- pyridin-2-yl...

Synonyms: Brocalax, Dulcolan, Stadalax, Theralax, Durolax, ...
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Disease relevance of Dulcolax


Psychiatry related information on Dulcolax

  • Bisacodyl was used to initiate colonic motor activity, and colonic transit was monitored using 99mTc-DPTA and a gamma camera [6].
  • The aim of this study was to compare oral intake of sodium phosphate solution (SP) with a conventional method of bowel preparation using Bisacodyl combined with repeated water enemas until the appearance of clear return fluid (BE) on bowel preparation and to compare patient compliance in a randomized-investigator blinded trial [7].
  • A randomized prospective trial was performed comparing Golytely (with bisacodyl) with our standard two-day catharsis and bowel washout regimen as colon preparation for double-contrast barium enema examinations [8].

High impact information on Dulcolax

  • Although there was no significant difference in the basal sigmoid motility index between constipated patients and controls, response to intrarectal bisacodyl (5 mg) was impaired in the constipated group, being 479 +/- 22.1 and 735 +/- 24.7, respectively (p less than 0.01) [9].
  • Fleet's enema and bisacodyl by rectum may mislead the proctologist and the pathologist by altering normal rectal mucosa [10].
  • Both Fleet's enema and bisacodyl caused sloughing of surface epithelium [10].
  • In addition, bisacodyl decreased the uptake of hematoxylin and eosin by crypt epithelial cells so that the affected cells had a partially erased appearance (16 of 25 biopsies examined by light microscopy) [10].
  • Bisacodyl inhibited water absorption in rat jejunum, ileum, and colon [11].

Biological context of Dulcolax

  • Defecation was initiated by a Dulcolax suppository [12].
  • The analytical method developed was based on liquid chromatographic determination after hydrolysis of the conjugated metabolite of bisacodyl and selective isolation from the urine [13].
  • When confronted by a combined team of cardiology, gastroenterology, and psychiatry specialist, she admitted her laxative abuse and surrendered her supply of Dulcolax tablets [5].
  • The purpose of this study was to determine some relationships between colonic myoelectric spiking activity and intraluminal propulsion when colonic peristalsis was stimulated by bisacodyl [14].
  • The stimulant laxatives, danthron, sennosid A and bisacodyl, significantly induced cell proliferation in almost the entire intestinal epithelia in a clear dose-dependent manner [15].

Anatomical context of Dulcolax

  • A 1978 household survey and a 1981 survey of stores and health facilities document the availability of breast milk substitutes, promotion of infant food and formula through the medical sector, and the effects of such promotion on the infant-feeding practices of mothers in the Bicol region of the Philippines [16].
  • Bisacodyl, used to test the functional integrity of the myenteric plexus, elicited strong propulsive contractions and urgency [17].
  • Regardless of route of administration to p53(+/-) mice, phenolphthalein but not bisacodyl was unequivocally genotoxic, causing increased micronuclei in polychromatic erythrocytes [18].
  • Golytely alone was successful in only 21 (53%) of 40 patients, but Golytely followed by Dulcolax achieved good or excellent feces removal in 31 (82%) of 38 [19].
  • BACKGROUND: Bisacodyl and colchicine affect smooth-muscle contractility, intestinal water, and electrolyte transport [20].

Associations of Dulcolax with other chemical compounds


Gene context of Dulcolax

  • METHODS: One hundred fifty consecutive patients (148 men) undergoing outpatient colonoscopy were randomly selected for one of three preparations (Prep 1: 4 L PEG-ELS; Prep 2: 2 L PEG-ELS plus 296 mL magnesium citrate 1 hour prior; Prep 3: 2 L PEG-ELS plus bisacodyl 20 mg) [26].
  • Reducing the proportion of pellets to 60% per tablet, less than 10% of bisacodyl were released within 2 h during acid treatment thus fulfilling the requirements of the USP 23 [27].
  • The expression of iNOS was unaffected by bowel preparation with bisacodyl or polyethylene glycol [28].
  • The sample was incubated with beta-glucuronidase at 37 degrees C for 2 h; bisacodyl metabolite was extracted with tert-butyl methyl ether, then derivatized by methylation, and subjected to gas chromatography-mass spectrometry [29].
  • We examined the effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) and (R)-7,8-dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1 -i]purin- 5(4H)-one (KF20274), selective adenosine A1-receptor antagonists, on the gastrointestinal propulsion in rats, as compared with those of the laxative bisacodyl [30].

Analytical, diagnostic and therapeutic context of Dulcolax


  1. Use of bisacodyl suppository in the diagnosis of amoebiasis. Vafai, M. Lancet (1982) [Pubmed]
  2. Efficacy and safety of bisacodyl in the acute treatment of constipation: a double-blind, randomized, placebo-controlled study. Kienzle-Horn, S., Vix, J.M., Schuijt, C., Peil, H., Jordan, C.C., Kamm, M.A. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  3. Bisacodyl and high-amplitude-propagating colonic contractions in children. Hamid, S.A., Di Lorenzo, C., Reddy, S.N., Flores, A.F., Hyman, P.E. J. Pediatr. Gastroenterol. Nutr. (1998) [Pubmed]
  4. Morphological consequences of bisacodyl on normal human rectal mucosa: effect of a prostaglandin E1 analog on mucosal injury. Saunders, D.R., Haggitt, R.C., Kimmey, M.B., Silverstein, F.E. Gastrointest. Endosc. (1990) [Pubmed]
  5. Hypokalemia leading to torsades de pointes. Munchausen's disorder or bulimia nervosa? Krahn, L.E., Lee, J., Richardson, J.W., Martin, M.J., O'Connor, M.K. General hospital psychiatry. (1997) [Pubmed]
  6. Dynamic scanning defines a colonic defect in severe idiopathic constipation. Kamm, M.A., Lennard-Jones, J.E., Thompson, D.G., Sobnack, R., Garvie, N.W., Granowska, M. Gut (1988) [Pubmed]
  7. Oral sodium phosphate compared with water enemas combined with bisacodyl as bowel preparation for elective colonoscopy. Rasmussen, M., Bohlbro, K., Qvist, N. Scand. J. Gastroenterol. (2003) [Pubmed]
  8. A comparison of Golytely and standard preparation for barium enema. Fitzsimons, P., Shorvon, P., Frost, R.A., Stevenson, G.W. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes. (1987) [Pubmed]
  9. Changes in colorectal function in severe idiopathic chronic constipation. Shouler, P., Keighley, M.R. Gastroenterology (1986) [Pubmed]
  10. Human rectal mucosa: proctoscopic and morphological changes caused by laxatives. Meisel, J.L., Bergman, D., Graney, D., Saunders, D.R., Rubin, C.E. Gastroenterology (1977) [Pubmed]
  11. Effect of bisacodyl on the structure and function of rodent and human intestine. Saunders, D.R., Sillery, J., Rachmilewitz, D., Rubin, C.E., Tytgat, G.N. Gastroenterology (1977) [Pubmed]
  12. Relaxation biofeedback conditioning as treatment of a disturbed defecation reflex. Report of a case. van Baal, J.G., Leguit, P., Brummelkamp, W.H. Dis. Colon Rectum (1984) [Pubmed]
  13. Quantitation of a bisacodyl metabolite in urine for the diagnosis of laxative abuse. Lööf, L., Hartvig, P., Lanbeck-Vallén, K., Lindström, B. Therapeutic drug monitoring. (1980) [Pubmed]
  14. Changes in colonic myoelectric spiking activity during stimulation by bisacodyl. Schang, J.C., Hémond, M., Hébert, M., Pilote, M. Can. J. Physiol. Pharmacol. (1986) [Pubmed]
  15. Cell proliferation induced by laxatives and related compounds in the rat intestine. Toyoda, K., Nishikawa, A., Furukawa, F., Kawanishi, T., Hayashi, Y., Takahashi, M. Cancer Lett. (1994) [Pubmed]
  16. Infant formula promotion and infant-feeding practices, Bicol region, Philippines. Griffin, C.C., Popkin, B.M., Spicer, D.S. American journal of public health. (1984) [Pubmed]
  17. Myoelectric and motor activity of the terminal ileum after pelvic pouch for ulcerative colitis. Pescatori, M. Dis. Colon Rectum (1985) [Pubmed]
  18. Phenolphthalein and bisacodyl: assessment of genotoxic and carcinogenic responses in heterozygous p53 (+/-) mice and syrian hamster embryo (SHE) assay. Stoll, R.E., Blanchard, K.T., Stoltz, J.H., Majeska, J.B., Furst, S., Lilly, P.D., Mennear, J.H. Toxicol. Sci. (2006) [Pubmed]
  19. Comparison of Golytely lavage with standard diet/cathartic preparation for double-contrast barium enema. Girard, C.M., Rugh, K.S., DiPalma, J.A., Brady, C.E., Pierson, W.P. AJR. American journal of roentgenology. (1984) [Pubmed]
  20. Effect of colchicine and bisacodyl on rat intestinal transit and nitric oxide synthase activity. Karmeli, F., Stalnikowicz, R., Rachmilewitz, D. Scand. J. Gastroenterol. (1997) [Pubmed]
  21. Value of bowel preparation in adrenocortical scintigraphy with NP-59. Shapiro, B., Nakajo, M., Gross, M.D., Freitas, J., Copp, J., Beierwaltes, W.H. J. Nucl. Med. (1983) [Pubmed]
  22. Randomized, controlled comparison of two forms of preparation for screening flexible sigmoidoscopy. Sharma, V.K., Chockalingham, S., Clark, V., Kapur, A., Steinberg, E.N., Heinzelmann, E.J., Vasudeva, R., Howden, C.W. Am. J. Gastroenterol. (1997) [Pubmed]
  23. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Ramkumar, D., Rao, S.S. Am. J. Gastroenterol. (2005) [Pubmed]
  24. Colostomy irrigation with prostaglandin E2 and bisacodyl. A double-blind cross-over study. Kjaergaard, J., Christensen, U., Stadil, F., Anderson, B. The British journal of surgery. (1984) [Pubmed]
  25. Oral sodium phosphate solution is a superior colonoscopy preparation to polyethylene glycol with bisacodyl. Young, C.J., Simpson, R.R., King, D.W., Lubowski, D.Z. Dis. Colon Rectum (2000) [Pubmed]
  26. Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation. Sharma, V.K., Chockalingham, S.K., Ugheoke, E.A., Kapur, A., Ling, P.H., Vasudeva, R., Howden, C.W. Gastrointest. Endosc. (1998) [Pubmed]
  27. Development of disintegrating multiple-unit tablets on a high-speed rotary tablet press. Wagner, K.G., Krumme, M., Beckert, T.E., Schmidt, P.C. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2000) [Pubmed]
  28. Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium. Perner, A., Andresen, L., Normark, M., Rask-Madsen, J. Scand. J. Gastroenterol. (2002) [Pubmed]
  29. Laxative poisoning: toxicological analysis of bisacodyl and its metabolite in urine, serum, and stool. Kudo, K., Miyazaki, C., Kadoya, R., Imamura, T., Jitsufuchi, N., Ikeda, N. Journal of analytical toxicology. (1998) [Pubmed]
  30. Effects of the adenosine A1-receptor antagonist on defecation, small intestinal propulsion and gastric emptying in rats. Suzuki, M., Tomaru, A., Kishibayashi, N., Karasawa, A. Jpn. J. Pharmacol. (1995) [Pubmed]
  31. A prospective randomized trial comparing low-dose oral sodium phosphate plus stimulant laxatives with large volume polyethylene glycol solution for colon cleansing. Hookey, L.C., Depew, W.T., Vanner, S.J. Am. J. Gastroenterol. (2004) [Pubmed]
  32. Review article: colon cleansing preparation for gastrointestinal procedures. Toledo, T.K., DiPalma, J.A. Aliment. Pharmacol. Ther. (2001) [Pubmed]
  33. A comparison of bowel preparations for flexible sigmoidoscopy: oral magnesium citrate combined with oral bisacodyl, one hypertonic phosphate enema, or two hypertonic phosphate enemas. Fincher, R.K., Osgard, E.M., Jackson, J.L., Strong, J.S., Wong, R.K. Am. J. Gastroenterol. (1999) [Pubmed]
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