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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Sigmoidoscopy


High impact information on Sigmoidoscopy

  • US Preventive Services Task Force. Sigmoidoscopy in the periodic health examination of asymptomatic adults [6].
  • METHODS: Participants were asymptomatic subjects who underwent screening flexible sigmoidoscopy (FSG) within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Subjects underwent single-slice, computerized tomography scanning to measure VAT and serum fasting insulin, IGF-I, and IGFBP-3 measurements [7].
  • The strategies included conventional serial flexible sigmoidoscopy and two different APC gene testing approaches [8].
  • Evaluations included a review of symptoms, flexible sigmoidoscopy, rectal biopsy, and rectal dialysis to measure prostaglandin E2 and leukotriene B4 levels [9].
  • Eight months later, a 72 hour oral rechallenge period of ranitidine, was performed immediately preceded (period 1) and followed (period 2) by sigmoidoscopy and biopsy [10].

Chemical compound and disease context of Sigmoidoscopy


Biological context of Sigmoidoscopy


Associations of Sigmoidoscopy with chemical compounds


Gene context of Sigmoidoscopy

  • Additionally, we identified a new FAP patient, in whom sigmoidoscopy showed the presence of adenomatous polyps throughout the colon [21].
  • Fecal alpha 1-antitrypsin was significantly higher in patients with mucosal disease visualized at upper endoscopy or flexible sigmoidoscopy than in those without gross abnormalities (13.5 +/- 5.8 mg/g dry stool versus 2.4 +/- 0.7 mg/g dry stool; P = 0.005) [22].
  • METHODS: From 1981-1983, 549 White men were examined by flexible sigmoidoscopy and completed self-administered questionnaires including smoking histories [23].
  • Peri-procedural discomfort was significantly more common in patients undergoing flexible sigmoidoscopy than with colonoscopy (p < 0.0005) [24].
  • CONCLUSIONS: For patients with CD4 counts < 100/mm3 and unexplained AIDS-related diarrhea, flexible sigmoidoscopy with biopsy is a sufficiently thorough endoscopic evaluation [25].

Analytical, diagnostic and therapeutic context of Sigmoidoscopy


  1. Screening men for prostate and colorectal cancer in the United States: does practice reflect the evidence? Sirovich, B.E., Schwartz, L.M., Woloshin, S. JAMA (2003) [Pubmed]
  2. Glutathione transferase (GSTM1) null genotype, smoking, and prevalence of colorectal adenomas. Lin, H.J., Probst-Hensch, N.M., Ingles, S.A., Han, C.Y., Lin, B.K., Lee, D.B., Frankl, H.D., Lee, E.R., Longnecker, M.P., Haile, R.W. Cancer Res. (1995) [Pubmed]
  3. Enterococcal endocarditis following sigmoidoscopy and mitral valve prolapse. Rigilano, J., Mahapatra, R., Barnhill, J., Gutierrez, J. Arch. Intern. Med. (1984) [Pubmed]
  4. Atypical mycobacterial infection of the gastrointestinal tract in AIDS patients. Gray, J.R., Rabeneck, L. Am. J. Gastroenterol. (1989) [Pubmed]
  5. Is colorectal cancer screening necessary in the preoperative assessment of inguinal herniorrhaphy? A case-control study. Gerson, L.B., Triadafilopoulos, G. Am. J. Gastroenterol. (2001) [Pubmed]
  6. US Preventive Services Task Force. Sigmoidoscopy in the periodic health examination of asymptomatic adults. Selby, J.V., Friedman, G.D. JAMA (1989) [Pubmed]
  7. Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Schoen, R.E., Weissfeld, J.L., Kuller, L.H., Thaete, F.L., Evans, R.W., Hayes, R.B., Rosen, C.J. Gastroenterology (2005) [Pubmed]
  8. Cost analysis of alternative approaches to colorectal screening in familial adenomatous polyposis. Cromwell, D.M., Moore, R.D., Brensinger, J.D., Petersen, G.M., Bass, E.B., Giardiello, F.M. Gastroenterology (1998) [Pubmed]
  9. Dietary supplementation with fish oil in ulcerative colitis. Stenson, W.F., Cort, D., Rodgers, J., Burakoff, R., DeSchryver-Kecskemeti, K., Gramlich, T.L., Beeken, W. Ann. Intern. Med. (1992) [Pubmed]
  10. Ranitidine, diarrhoea, and lymphocytic colitis. Beaugerie, L., Patey, N., Brousse, N. Gut (1995) [Pubmed]
  11. High-resolution chromoendoscopy for classifying colonic polyps: a multicenter study. Eisen, G.M., Kim, C.Y., Fleischer, D.E., Kozarek, R.A., Carr-Locke, D.L., Li, T.C., Gostout, C.J., Heller, S.J., Montgomery, E.A., Al-Kawas, F.H., Lewis, J.H., Benjamin, S.B. Gastrointest. Endosc. (2002) [Pubmed]
  12. Rectosigmoid lipoma an unusual colonic lipoma. Case report and review of the literature. Bolaños, G., Camps, J.I., Figueroa, M.J., Ortiz, V.N. Boletín de la Asociación Médica de Puerto Rico. (1994) [Pubmed]
  13. Liposarcoma of the mesocolon--case report of a rare lesion. Goel, A.K., Sinha, S., Kumar, A., Karak, A.K., Chattopadhyay, T.K. Surgery today. (1994) [Pubmed]
  14. Nitrous oxide inhalation as sedation for flexible sigmoidoscopy. Fich, A., Efrat, R., Sperber, A.D., Wengrower, D., Goldin, E. Gastrointest. Endosc. (1997) [Pubmed]
  15. Comparison of omega-3 fatty acids and sulfasalazine in ulcerative colitis. Dichi, I., Frenhane, P., Dichi, J.B., Correa, C.R., Angeleli, A.Y., Bicudo, M.H., Rodrigues, M.A., Victória, C.R., Burini, R.C. Nutrition (Burbank, Los Angeles County, Calif.) (2000) [Pubmed]
  16. Colorectal leukotriene B4 synthesis in vitro in inflammatory bowel disease: inhibition by the selective 5-lipoxygenase inhibitor BWA4C. Hawthorne, A.B., Boughton-Smith, N.K., Whittle, B.J., Hawkey, C.J. Gut (1992) [Pubmed]
  17. A comparison of bowel preparations for flexible sigmoidoscopy: oral magnesium citrate combined with oral bisacodyl, one hypertonic phosphate enema, or two hypertonic phosphate enemas. Fincher, R.K., Osgard, E.M., Jackson, J.L., Strong, J.S., Wong, R.K. Am. J. Gastroenterol. (1999) [Pubmed]
  18. A randomized trial comparing three methods of bowel preparation for flexible sigmoidoscopy. Osgard, E., Jackson, J.L., Strong, J. Am. J. Gastroenterol. (1998) [Pubmed]
  19. A randomized, controlled trial to assess a novel colorectal cancer screening strategy: the conversion strategy--a comparison of sequential sigmoidoscopy and colonoscopy with immediate conversion from sigmoidoscopy to colonoscopy in patients with an abnormal screening sigmoidoscopy. Stern, M.A., Fendrick, A.M., McDonnell, W.M., Gunaratnam, N., Moseley, R., Chey, W.D. Am. J. Gastroenterol. (2000) [Pubmed]
  20. Glutaraldehyde as a possible cause of diarrhoea after sigmoidoscopy. Hanson, J.M., Plusa, S.M., Bennett, M.K., Browell, D.A., Cunliffe, W.J. The British journal of surgery. (1998) [Pubmed]
  21. The use of DNA markers in the pre-clinical diagnosis of familial adenomatous polyposis. Amikam, D., Niv, D., Lachter, J., Eidelman, S., Ben-Ishai, Z. Isr. J. Med. Sci. (1997) [Pubmed]
  22. Protein-losing enteropathy and hypoalbuminemia in AIDS. Laine, L., Garcia, F., McGilligan, K., Malinko, A., Sinatra, F.R., Thomas, D.W. AIDS (1993) [Pubmed]
  23. Tobacco smoking as a risk factor for colon polyps. Zahm, S.H., Cocco, P., Blair, A. American journal of public health. (1991) [Pubmed]
  24. Procedure-related abdominal discomfort in patients undergoing colorectal cancer screening: a comparison of colonoscopy and flexible sigmoidoscopy. Zubarik, R., Ganguly, E., Benway, D., Ferrentino, N., Moses, P., Vecchio, J. Am. J. Gastroenterol. (2002) [Pubmed]
  25. A prospective study of endoscopy in HIV-associated diarrhea. Kearney, D.J., Steuerwald, M., Koch, J., Cello, J.P. Am. J. Gastroenterol. (1999) [Pubmed]
  26. The clinical significance of antibiotic-associated pseudomembranous colitis in the 1990s. Andréjak, M., Schmit, J.L., Tondriaux, A. Drug safety : an international journal of medical toxicology and drug experience. (1991) [Pubmed]
  27. Sublingual hyoscyamine for patient comfort during screening sigmoidoscopy: a randomized, double-blind, placebo-controlled clinical trial. Dumot, J.A., Verzola, E., Nicol, S., Easley, K.A., Vargo, J.J., van Stolk, R.U. Gastrointest. Endosc. (1998) [Pubmed]
  28. Colon cancer screening in the ambulatory setting. Walsh, J.M., Posner, S.F., Perez-Stable, E.J. Preventive medicine. (2002) [Pubmed]
  29. Colorectal cancer screening, 1997-1999: role of income, insurance and policy. Adams, E.K., Thorpe, K.E., Becker, E.R., Joski, P.J., Flome, J. Preventive medicine. (2004) [Pubmed]
  30. Carbon dioxide insufflation reduces discomfort due to flexible sigmoidoscopy in colorectal cancer screening. Bretthauer, M., Hoff, G., Thiis-Evensen, E., Grotmol, T., Holmsen, S.T., Moritz, V., Skovlund, E. Scand. J. Gastroenterol. (2002) [Pubmed]
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