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Chemical Compound Review

AG-D-55504     2-[2-[3-[[(2R)-4- [[[(2R,3S,4R,5R)-5-(6...

Synonyms: CHEBI:16625, AC1Q5ROZ, CTK4B5185, AR-1J6699, AC1L3XJ1, ...
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Disease relevance of Methylmalonyl coenzyme A


High impact information on Methylmalonyl coenzyme A


Chemical compound and disease context of Methylmalonyl coenzyme A


Biological context of Methylmalonyl coenzyme A


Associations of Methylmalonyl coenzyme A with other chemical compounds


Gene context of Methylmalonyl coenzyme A

  • One Hutterite child was previously known to have methylmalonyl-coenzyme A (MMCoA) mutase deficiency (mut0) which is unresponsive to vitamin B12 but is responsive to diet and other therapeutic measures [19].

Analytical, diagnostic and therapeutic context of Methylmalonyl coenzyme A


  1. Synthesis of mycocerosic acids from methylmalonyl coenzyme A by cell-free extracts of Mycobacterium tuberculosis var. bovis BCG. Rainwater, D.L., Kolattukudy, P.E. J. Biol. Chem. (1983) [Pubmed]
  2. Source of methylmalonyl-coenzyme A for erythromycin synthesis: methylmalonyl-coenzyme A mutase from Streptomyces erythreus. Hunaiti, A.A., Kolattukudy, P.E. Antimicrob. Agents Chemother. (1984) [Pubmed]
  3. Metabolic pathway for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) formation in Nocardia corallina: inactivation of mutB by chromosomal integration of a kanamycin resistance gene. Valentin, H.F., Dennis, D. Appl. Environ. Microbiol. (1996) [Pubmed]
  4. Expression of the sodium ion pump methylmalonyl-coenzyme A-decarboxylase from Veillonella parvula and of mutated enzyme specimens in Escherichia coli. Huder, J.B., Dimroth, P. J. Bacteriol. (1995) [Pubmed]
  5. Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives. Ruan, X., Pereda, A., Stassi, D.L., Zeidner, D., Summers, R.G., Jackson, M., Shivakumar, A., Kakavas, S., Staver, M.J., Donadio, S., Katz, L. J. Bacteriol. (1997) [Pubmed]
  6. Methylmalonic aciduria without vitamin B12 deficiency in an adult sibship. Giorgio, A.J., Trowbridge, M., Boone, A.W., Patten, R.S. N. Engl. J. Med. (1976) [Pubmed]
  7. Genetic characterization of a MUT locus mutation discriminating heterogeneity in mut0 and mut- methylmalonic aciduria by interallelic complementation. Raff, M.L., Crane, A.M., Jansen, R., Ledley, F.D., Rosenblatt, D.S. J. Clin. Invest. (1991) [Pubmed]
  8. Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase. Pieper, R., Gokhale, R.S., Luo, G., Cane, D.E., Khosla, C. Biochemistry (1997) [Pubmed]
  9. Incorporation of amino acid-derived carbon into tylactone by Streptomyces fradiae GS14. Dotzlaf, J.E., Metzger, L.S., Foglesong, M.A. Antimicrob. Agents Chemother. (1984) [Pubmed]
  10. Lipid biosynthesis in the sebaceous glands: synthesis of multibranched fatty acids from methylmalonyl-coenzyme A in cell-free preparations from the uropygial gland of goose. Buckner, J.S., Kolattukudy, P.E. Biochemistry (1975) [Pubmed]
  11. Insertional inactivation of methylmalonyl coenzyme A (CoA) mutase and isobutyryl-CoA mutase genes in Streptomyces cinnamonensis: influence on polyketide antibiotic biosynthesis. Vrijbloed, J.W., Zerbe-Burkhardt, K., Ratnatilleke, A., Grubelnik-Leiser, A., Robinson, J.A. J. Bacteriol. (1999) [Pubmed]
  12. MeaA, a putative coenzyme B12-dependent mutase, provides methylmalonyl coenzyme A for monensin biosynthesis in Streptomyces cinnamonensis. Zhang, W., Reynolds, K.A. J. Bacteriol. (2001) [Pubmed]
  13. Methylmalonyl coenzyme A selectivity of cloned and expressed acyltransferase and beta-ketoacyl synthase domains of mycocerosic acid synthase from Mycobacterium bovis BCG. Fernandes, N.D., Kolattukudy, P.E. J. Bacteriol. (1997) [Pubmed]
  14. Effects of somatotropin and substrates on patterns of liver metabolism in lactating dairy cattle. Knapp, J.R., Freetly, H.C., Reis, B.L., Calvert, C.C., Baldwin, R.L. J. Dairy Sci. (1992) [Pubmed]
  15. Studies of methylmalonyl-coenzyme A carbonylmutase activity in methylmalonic acidemia. II. In vitro binding kinetics with adenosylcobalamin. Morrow, G., Lebowitz, J. Biochemical medicine. (1976) [Pubmed]
  16. Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism. Lerner-Ellis, J.P., Dobson, C.M., Wai, T., Watkins, D., Tirone, J.C., Leclerc, D., Doré, C., Lepage, P., Gravel, R.A., Rosenblatt, D.S. Hum. Mutat. (2004) [Pubmed]
  17. Comparison of two methods for the measurement of rat liver methylmalonyl-coenzyme A mutase activity: HPLC and radioisotopic assays. Gaire, D., Sponne, I., Droesch, S., Charlier, A., Nicolas, J.P., Lambert, D. J. Nutr. Biochem. (1999) [Pubmed]
  18. Determination of the binding specificity of the 12S subunit of the transcarboxylase by saturation transfer difference NMR. Peikert, C., Seeger, K., Bhat, R.K., Berger, S. Org. Biomol. Chem. (2004) [Pubmed]
  19. Screening for methylmalonic aciduria in Alberta: a voluntary program with particular significance for the Hutterite Brethren. Fowlow, S.B., Holmes, T.M., Morgan, K., Snyder, F.F. Am. J. Med. Genet. (1985) [Pubmed]
  20. Expression, crystallization and preliminary characterization of methylmalonyl coenzyme A epimerase from Propionibacterium shermanii. McCarthy, A.A., Baker, H.M., Shewry, S.C., Kagawa, T.F., Saafi, E., Patchett, M.L., Baker, E.N. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
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