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Gene Review

CETN2  -  centrin, EF-hand protein, 2

Homo sapiens

Synonyms: CALT, CEN2, Caltractin isoform 1, Centrin-2
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Disease relevance of CETN2


High impact information on CETN2


Biological context of CETN2


Anatomical context of CETN2

  • CEN2 has been shown to play an important role in centrosome duplication [1].
  • Centrin-2 is required for centriole duplication in mammalian cells [7].
  • We found only one example of organised conjunctival lymphoid tissue in our study and suggest that the presence of CALT in humans is not universal [9].

Associations of CETN2 with chemical compounds

  • The two standard peptides bind human centrin 2 and its isolated C-terminal domain with high affinity ( approximately 10(7) m(-1)) by an enthalpy-driven mechanism, with a moderate Ca(2+) dependence [6].

Physical interactions of CETN2


Other interactions of CETN2


Analytical, diagnostic and therapeutic context of CETN2


  1. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. Araki, M., Masutani, C., Takemura, M., Uchida, A., Sugasawa, K., Kondoh, J., Ohkuma, Y., Hanaoka, F. J. Biol. Chem. (2001) [Pubmed]
  2. Caloric tests on platform: "paradoxical responsiveness". Hadj-Djilani, A.M. Acta oto-laryngologica. Supplementum. (1995) [Pubmed]
  3. Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. Nishi, R., Okuda, Y., Watanabe, E., Mori, T., Iwai, S., Masutani, C., Sugasawa, K., Hanaoka, F. Mol. Cell. Biol. (2005) [Pubmed]
  4. The structure of the human centrin 2-xeroderma pigmentosum group C protein complex. Thompson, J.R., Ryan, Z.C., Salisbury, J.L., Kumar, R. J. Biol. Chem. (2006) [Pubmed]
  5. Xeroderma pigmentosum group C protein possesses a high affinity binding site to human centrin 2 and calmodulin. Popescu, A., Miron, S., Blouquit, Y., Duchambon, P., Christova, P., Craescu, C.T. J. Biol. Chem. (2003) [Pubmed]
  6. Binding of human centrin 2 to the centrosomal protein hSfi1. Martinez-Sanz, J., Yang, A., Blouquit, Y., Duchambon, P., Assairi, L., Craescu, C.T. FEBS J. (2006) [Pubmed]
  7. Centrin-2 is required for centriole duplication in mammalian cells. Salisbury, J.L., Suino, K.M., Busby, R., Springett, M. Curr. Biol. (2002) [Pubmed]
  8. Centrin isoforms in mammals. Relation to calmodulin. Friedberg, F. Mol. Biol. Rep. (2006) [Pubmed]
  9. Characterisation of the normal conjunctival leukocyte population. Hingorani, M., Metz, D., Lightman, S.L. Exp. Eye Res. (1997) [Pubmed]
  10. Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair. Yang, A., Miron, S., Mouawad, L., Duchambon, P., Blouquit, Y., Craescu, C.T. Biochemistry (2006) [Pubmed]
  11. Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization. Tanaka, T., Okui, K., Nakamura, Y. Genomics (1994) [Pubmed]
  12. Crystallization and preliminary X-ray diffraction data of the complex between human centrin 2 and a peptide from the protein XPC. Charbonnier, J.B., Christova, P., Shosheva, A., Stura, E., Le Du, M.H., Blouquit, Y., Duchambon, P., Miron, S., Craescu, C.T. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
  13. Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. Laoukili, J., Perret, E., Middendorp, S., Houcine, O., Guennou, C., Marano, F., Bornens, M., Tournier, F. J. Cell. Sci. (2000) [Pubmed]
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