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Gene Review

BVES  -  blood vessel epicardial substance

Homo sapiens

Synonyms: Blood vessel epicardial substance, HBVES, POP1, POPDC1, Popeye domain-containing protein 1, ...
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Disease relevance of BVES

  • In the present work the NA gene from the H1N1 influenza virus strain A/Beijing/262/95 was cloned from viral RNA and expressed in expresSF+ insect cells using the baculovirus expression vector system (BVES) [1].
  • Popeye ate spinach because the association of spinach with strength was a product of the first national nutrition crisis in the United States: the 1920s fight against child malnutrition [2].
  • The Popeye syndrome--brachial artery entrapment as a result of muscular hypertrophy [3].

High impact information on BVES

  • We conclude that a MAPK-related pathway cooperates with Wnt signal transduction to downregulate POP-1 activity [4].
  • We identify three lysines that are acetylated in vivo, and demonstrate their essential requirement for proper nuclear localization and biological activity of POP-1 during C. elegans embryogenesis [5].
  • Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1 [5].
  • Here we report that acetylation enhances nuclear retention of POP-1, the Caenorhabditis elegans LEF/TCF homolog, through increasing nuclear import and blocking nuclear export [5].
  • All our data suggest that RNT-1/MAB-2 functions with POP-1 to control the asymmetry of the T cell division [6].

Biological context of BVES

  • Chromosomal mapping indicates that Pop1 and Pop3 genes are clustered on mouse chromosome 10, whereas Pop2 maps to mouse chromosome 16 [7].
  • Bves (blood vessel/epicardial substance) is a transmembrane protein postulated to play a role in cell adhesion [8].
  • Furthermore, Bves protein is observed in epithelial tissues during organogenesis, specifically the developing epidermis, the gut endoderm, and the epicardium of the heart [8].
  • Expression of bves antisense RNA during oogenesis causes reduced viability in the resulting embryos [9].
  • In POP 1, no differences were seen among genotypes in disease symptom severity, number and severity of adverse drug effects, or attitudes toward drug treatment at baseline and at the end of the study [10].

Anatomical context of BVES

  • The enzymatic properties of the re-proteins and their inhibition by protein kinase inhibitors were comparable to the native enzyme (LCK N) derived from Jurkat cells and wild-type LCK derived from the BVES [11].
  • Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart [7].
  • Pop1 and Pop2 expression is upregulated in uterus of pregnant mice [7].
  • Presently, the literature supports a hypothesis that Bves is essential to the junctional architecture of muscle and epithelial cell types [12].
  • In this study, we present an expression analysis of Bves during chick gastrulation and germ layer formation [8].


  1. Development of recombinant protein-based influenza vaccine Expression and affinity purification of H1N1 influenza virus neuraminidase. Dalakouras, T., Smith, B.J., Platis, D., Cox, M.M., Labrou, N.E. Journal of chromatography. A (2006) [Pubmed]
  2. The Popeye principle: selling child health in the first nutrition crisis. Lovett, L. Journal of health politics, policy and law. (2005) [Pubmed]
  3. The Popeye syndrome--brachial artery entrapment as a result of muscular hypertrophy. Biemans, R.G. The Netherlands journal of surgery. (1984) [Pubmed]
  4. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Meneghini, M.D., Ishitani, T., Carter, J.C., Hisamoto, N., Ninomiya-Tsuji, J., Thorpe, C.J., Hamill, D.R., Matsumoto, K., Bowerman, B. Nature (1999) [Pubmed]
  5. Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1. Gay, F., Calvo, D., Lo, M.C., Ceron, J., Maduro, M., Lin, R., Shi, Y. Genes Dev. (2003) [Pubmed]
  6. The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell. Kagoshima, H., Sawa, H., Mitani, S., Bürglin, T.R., Shigesada, K., Kohara, Y. Dev. Biol. (2005) [Pubmed]
  7. Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. Andrée, B., Hillemann, T., Kessler-Icekson, G., Schmitt-John, T., Jockusch, H., Arnold, H.H., Brand, T. Dev. Biol. (2000) [Pubmed]
  8. Bves expression during avian embryogenesis. Osler, M.E., Bader, D.M. Dev. Dyn. (2004) [Pubmed]
  9. Blood vessel/epicardial substance (bves) expression, essential for embryonic development, is down regulated by Grk/EFGR signalling. Lin, S., Zhao, D., Bownes, M. Int. J. Dev. Biol. (2007) [Pubmed]
  10. CYP2D6 mutations and therapeutic outcome in schizophrenic patients. Hamelin, B.A., Dorson, P.G., Pabis, D., Still, D., Bouchard, R.H., Pourcher, E., Rail, J., Turgeon, J., Crismon, M.L. Pharmacotherapy (1999) [Pubmed]
  11. Production, purification and characterization of non-myristylated human T-cell protein tyrosine kinase in a baculovirus expression system. Lehr, R.V., Ma, Y.G., Kratz, D., Brake, P.G., Wang, S., Faltynek, C.R., Wang, X.M., Stevis, P.E. Gene (1996) [Pubmed]
  12. Bves, a member of the Popeye domain-containing gene family. Osler, M.E., Smith, T.K., Bader, D.M. Dev. Dyn. (2006) [Pubmed]
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