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Gene Review

CD300A  -  CD300a molecule

Homo sapiens

Synonyms: CD300 antigen-like family member A, CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, ...
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Disease relevance of CD300A


High impact information on CD300A


Biological context of CD300A

  • The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17 [6].
  • An immune complex-mediated cross-linking of IRp60 led to inhibition of IgE-induced degranulation and stem cell factor-mediated survival via a mechanism involving tyrosine phosphorylation, phosphatase recruitment, and termination of cellular calcium influx [4].
  • The genes for the CMRF-35A and CMRF-35H molecules are closely linked on chromosome 17 [7].

Anatomical context of CD300A

  • The function of these molecules is unknown, however the presence of putative immunoreceptor tyrosine-based inhibitory motifs (ITIM) in the cytoplasmic domain of the CMRF-35H molecule suggests that this molecule may play a regulatory role in leukocyte function [6].
  • These data demonstrate a novel pathway for the regulation of human mast cell function and allergic responses, indicating IRp60 as a candidate target for future treatment of allergic and mast cell-associated diseases [4].
  • Since IRp60 is also expressed by other cell types, including T cell subsets, monocytes and granulocytes, it may play a more general role in the negative regulation of different leukocyte populations [8].
  • Specific radioreceptor assays for FSH and LH, which employ tissue receptors from rat testis and highly purified human FSH (LER 1575-C) and LH (Hartree IRC-2, 24/6/69) as standards, have been developed to determine the FSH-like and LH-like activities in pregnant mare serum gonadotropin (PMSG) [9].

Other interactions of CD300A

  • This would further indicate that, like other ITIM/ITAM containing molecules, CMRF-35H/CMRF-35A will also play an important role in the immune response [6].
  • Since there is a strong association between Ankylosing Spondylitis (AS) and HLA-B27, which is specifically recognized by the NK-inhibitory receptor KIR3DL1, this study evaluated the potential involvement of NK cells in AS [10].

Analytical, diagnostic and therapeutic context of CD300A

  • Southern blot analysis revealed cross-hybridization with monkey and mouse genomic DNA, thus suggesting that IRp60 may be conserved among different species [8].
  • Purified preparations of human luteinizing hormone (hLH), Hartree IRC-2, and NIH LER-960, have been examined after gel filtration of unlabelled and iodinated hormone [11].


  1. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Ikeda, H., Lethé, B., Lehmann, F., van Baren, N., Baurain, J.F., de Smet, C., Chambost, H., Vitale, M., Moretta, A., Boon, T., Coulie, P.G. Immunity (1997) [Pubmed]
  2. Sister cytotoxic CD8+ T cell clones differing in natural killer inhibitory receptor expression in human astrocytoma. Perrin, G., Speiser, D., Porret, A., Quiquerez, A.L., Walker, P.R., Dietrich, P.Y. Immunol. Lett. (2002) [Pubmed]
  3. The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils. Munitz, A., Bachelet, I., Eliashar, R., Moretta, A., Moretta, L., Levi-Schaffer, F. Blood (2006) [Pubmed]
  4. The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. Bachelet, I., Munitz, A., Moretta, A., Moretta, L., Levi-Schaffer, F. J. Immunol. (2005) [Pubmed]
  5. IREM-1 is a novel inhibitory receptor expressed by myeloid cells. Alvarez-Errico, D., Aguilar, H., Kitzig, F., Brckalo, T., Sayós, J., López-Botet, M. Eur. J. Immunol. (2004) [Pubmed]
  6. The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. Clark, G.J., Green, B.J., Hart, D.N. Tissue Antigens (2000) [Pubmed]
  7. The gene encoding the immunoregulatory signaling molecule CMRF-35A localized to human chromosome 17 in close proximity to other members of the CMRF-35 family. Clark, G.J., Cooper, B., Fitzpatrick, S., Green, B.J., Hart, D.N. Tissue Antigens (2001) [Pubmed]
  8. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. Cantoni, C., Bottino, C., Augugliaro, R., Morelli, L., Marcenaro, E., Castriconi, R., Vitale, M., Pende, D., Sivori, S., Millo, R., Biassoni, R., Moretta, L., Moretta, A. Eur. J. Immunol. (1999) [Pubmed]
  9. Pregnant mare serum gonadotrophin: ratio of follicle-stimulating hormone and luteinizing hormone activities measured by radioreceptor assay. Stewart, F., Allen, W.R., Moor, R.M. J. Endocrinol. (1976) [Pubmed]
  10. The involvement of NK cells in ankylosing spondylitis. Azuz-Lieberman, N., Markel, G., Mizrahi, S., Gazit, R., Hanna, J., Achdout, H., Gruda, R., Katz, G., Arnon, T.I., Battat, S., Zamir, E., Adawi, M., Mader, R., Mandelboim, O. Int. Immunol. (2005) [Pubmed]
  11. Heterogeneity of purified human pituitary luteinizing hormone: effect on hormone measurement by radioimmunoassay. Benveniste, R., Frohman, L.A., Rabinowitz, D. Endocrinology (1975) [Pubmed]
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