The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tnc  -  tenascin C

Rattus norvegicus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tnc


High impact information on Tnc


Chemical compound and disease context of Tnc


Biological context of Tnc


Anatomical context of Tnc

  • Tenascin-C regulates proliferation and migration of cultured astrocytes in a scratch wound assay [10].
  • Our results show novel expression patterns and cell associations of inhibitory CSPGs and tenascin-C that have important implications for axon regeneration across acute and chronic spinal cord scar tissue [13].
  • A mechanism of impaired mobility of oligodendrocyte progenitor cells by tenascin C through modification of wnt signaling [14].
  • After wounding, glial cells rapidly released the largest TNC isoform and proliferated in the border zones [10].
  • Our results suggest that tenascin C is involved in the impaired mobility of OLG progenitor cells through increased amounts of adhesion complex as well as the prevention of wnt signaling [14].

Associations of Tnc with chemical compounds

  • An angiotensin II receptor type 1 antagonist inhibited mechanical induction of brain natriuretic peptide but not tenascin-C [15].
  • Antioxidants such as N-acetyl-L-cysteine, catalase, and 1, 2-dihydroxy-benzene-3,5-disulfonate significantly inhibited induction of tenascin-C [15].
  • Selective depletion of this monocytic cell population, using either clodronate-liposomes or gadolinium chloride, prevented pulmonary adventitial remodeling (ie, production of collagen, fibronectin, and tenascin-C and accumulation of myofibroblasts) [16].
  • Mechanical strain induced tenascin-C mRNA (3.9 +/- 0.5-fold, p < 0.01, n = 13) and tenascin-C protein in an amplitude-dependent manner but did not induce secreted protein acidic and rich in cysteine nor fibronectin [15].
  • In experiments using various protein kinase inhibitors, we observed that selective inhibitors of cyclic GMP-dependent protein kinase, KT5823 and Rp-8-Br-cGMPS, blocked the effects of both the active sequence of thrombospondin 1 (hep I) and the alternatively-spliced segment (TNfnA-D) of tenascin-C on focal adhesion disassembly [17].

Physical interactions of Tnc


Regulatory relationships of Tnc


Other interactions of Tnc


Analytical, diagnostic and therapeutic context of Tnc


  1. Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Cowan, K.N., Heilbut, A., Humpl, T., Lam, C., Ito, S., Rabinovitch, M. Nat. Med. (2000) [Pubmed]
  2. Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease. Cowan, K.N., Jones, P.L., Rabinovitch, M. J. Clin. Invest. (2000) [Pubmed]
  3. Effects of tenascin-C in cultured hippocampal astrocytes: NCAM and fibronectin immunoreactivity changes. Mahler, M., Ferhat, L., Ben-Ari, Y., Represa, A. Glia (1997) [Pubmed]
  4. Serotonergic reinnervation reverses lesion-induced decreases in PSA-NCAM labeling and proliferation of hippocampal cells in adult rats. Brezun, J.M., Daszuta, A. Hippocampus. (2000) [Pubmed]
  5. Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells. Alvarez-Dolado, M., González-Sancho, J.M., Navarro-Yubero, C., García-Fernández, L.F., Muñoz, A. J. Neurosci. Res. (1999) [Pubmed]
  6. Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R. Srinivasan, J., Schachner, M., Catterall, W.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  7. Tenascin-C is induced with progressive pulmonary vascular disease in rats and is functionally related to increased smooth muscle cell proliferation. Jones, P.L., Rabinovitch, M. Circ. Res. (1996) [Pubmed]
  8. Locally applied cilostazol suppresses neointimal hyperplasia by inhibiting tenascin-C synthesis and smooth muscle cell proliferation in free artery grafts. Fujinaga, K., Onoda, K., Yamamoto, K., Imanaka-Yoshida, K., Takao, M., Shimono, T., Shimpo, H., Yoshida, T., Yada, I. J. Thorac. Cardiovasc. Surg. (2004) [Pubmed]
  9. Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and smooth muscle cell apoptosis. Cowan, K.N., Jones, P.L., Rabinovitch, M. Circ. Res. (1999) [Pubmed]
  10. Tenascin-C regulates proliferation and migration of cultured astrocytes in a scratch wound assay. Nishio, T., Kawaguchi, S., Yamamoto, M., Iseda, T., Kawasaki, T., Hase, T. Neuroscience (2005) [Pubmed]
  11. Balloon catheterization induces arterial expression of new Tenascin-C isoform. Wallner, K., Shah, P.K., Sharifi, B.G. Atherosclerosis (2002) [Pubmed]
  12. Secretion of tenascin-C by cultured astrocytes: regulation of cell proliferation and process elongation. Nishio, T., Kawaguchi, S., Iseda, T., Kawasaki, T., Hase, T. Brain Res. (2003) [Pubmed]
  13. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. Tang, X., Davies, J.E., Davies, S.J. J. Neurosci. Res. (2003) [Pubmed]
  14. A mechanism of impaired mobility of oligodendrocyte progenitor cells by tenascin C through modification of wnt signaling. Kakinuma, Y., Saito, F., Osawa, S., Miura, M. FEBS Lett. (2004) [Pubmed]
  15. Induction of tenascin-C in cardiac myocytes by mechanical deformation. Role of reactive oxygen species. Yamamoto, K., Dang, Q.N., Kennedy, S.P., Osathanondh, R., Kelly, R.A., Lee, R.T. J. Biol. Chem. (1999) [Pubmed]
  16. Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Frid, M.G., Brunetti, J.A., Burke, D.L., Carpenter, T.C., Davie, N.J., Reeves, J.T., Roedersheimer, M.T., van Rooijen, N., Stenmark, K.R. Am. J. Pathol. (2006) [Pubmed]
  17. Cyclic GMP-dependent protein kinase is required for thrombospondin and tenascin mediated focal adhesion disassembly. Murphy-Ullrich, J.E., Pallero, M.A., Boerth, N., Greenwood, J.A., Lincoln, T.M., Cornwell, T.L. J. Cell. Sci. (1996) [Pubmed]
  18. Tenascin-C in rat lung: distribution, ontogeny and role in branching morphogenesis. Young, S.L., Chang, L.Y., Erickson, H.P. Dev. Biol. (1994) [Pubmed]
  19. Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts. II. Tenascin-C. Zhang, Y., Campbell, G., Anderson, P.N., Martini, R., Schachner, M., Lieberman, A.R. J. Comp. Neurol. (1995) [Pubmed]
  20. Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension. Schermuly, R.T., Yilmaz, H., Ghofrani, H.A., Woyda, K., Pullamsetti, S., Schulz, A., Gessler, T., Dumitrascu, R., Weissmann, N., Grimminger, F., Seeger, W. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  21. Inhibition of matrix metalloproteinase activity attenuates tenascin-C production and calcification of implanted purified elastin in rats. Vyavahare, N., Jones, P.L., Tallapragada, S., Levy, R.J. Am. J. Pathol. (2000) [Pubmed]
  22. Distribution of tenascin-C and tenascin-X, apoptotic and proliferating cells in postnatal soft-diet rat temporomandibular joint (TMJ). Sato, I., Uneno, R., Miwa, Y., Sunohara, M. Ann. Anat. (2006) [Pubmed]
  23. Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition. Bouvet, C., Gilbert, L.A., Girardot, D., deBlois, D., Moreau, P. Hypertension (2005) [Pubmed]
WikiGenes - Universities