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Gene Review

Tjp2  -  tight junction protein 2

Rattus norvegicus

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Disease relevance of Tjp2


High impact information on Tjp2


Biological context of Tjp2

  • ZO-2 is particularly intriguing both because of this tight junction gene's pattern of prolonged over-expression after injury and because of its potential role in determining the distinctive epithelioid phenotype of smooth muscle cells identified in rat and other species [6].
  • We found that in the latter condition the phosphorylation level of ZO-2 is significantly higher and is due to the action of both PKC and cAMP-dependent protein kinase [7].

Anatomical context of Tjp2


Associations of Tjp2 with chemical compounds


Other interactions of Tjp2

  • We confirmed the interaction of ZO-2 with Cx43 by using a combination of fusion protein "pull down," co-immunoprecipitation, and co-localization experiments [5].
  • ZO-2 and alpha1(I)collagen messages were modulated for up to a month, whereas SPARC message showed no consistent change [6].

Analytical, diagnostic and therapeutic context of Tjp2

  • We have further characterized some of these interacting proteins, including Zonula Occludens-2 (ZO-2), via western blotting and "pull down" experiments [9].


  1. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Mark, K.S., Davis, T.P. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  2. Connexin-occludin chimeras containing the ZO-binding domain of occludin localize at MDCK tight junctions and NRK cell contacts. Mitic, L.L., Schneeberger, E.E., Fanning, A.S., Anderson, J.M. J. Cell Biol. (1999) [Pubmed]
  3. The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells. Yamamoto, T., Harada, N., Kano, K., Taya, S., Canaani, E., Matsuura, Y., Mizoguchi, A., Ide, C., Kaibuchi, K. J. Cell Biol. (1997) [Pubmed]
  4. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. Müller, B.M., Kistner, U., Veh, R.W., Cases-Langhoff, C., Becker, B., Gundelfinger, E.D., Garner, C.C. J. Neurosci. (1995) [Pubmed]
  5. Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner. Singh, D., Solan, J.L., Taffet, S.M., Javier, R., Lampe, P.D. J. Biol. Chem. (2005) [Pubmed]
  6. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams, L.D., Lemire, J.M., Schwartz, S.M. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  7. Tight-junction protein zonula occludens 2 is a target of phosphorylation by protein kinase C. Avila-Flores, A., Rendón-Huerta, E., Moreno, J., Islas, S., Betanzos, A., Robles-Flores, M., González-Mariscal, L. Biochem. J. (2001) [Pubmed]
  8. Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. Yi, X., Wang, Y., Yu, F.S. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  9. Identification of connexin-43 interacting proteins. Singh, D., Lampe, P.D. Cell Commun. Adhes. (2003) [Pubmed]
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