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Gene Review

Neu2  -  sialidase 2

Rattus norvegicus

Synonyms: Cytosolic sialidase, N-acetyl-alpha-neuraminidase 2, Sialidase-2
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Disease relevance of Neu2

  • The levels of lysosomal and cytosolic sialidase activities in liver and hepatomas were then studied in the pellet and supernatant fractions, respectively, obtained by centrifuging the postnuclear supernatant at 105,000g for 1 hr [1].

High impact information on Neu2


Biological context of Neu2


Anatomical context of Neu2


Associations of Neu2 with chemical compounds


Other interactions of Neu2


Analytical, diagnostic and therapeutic context of Neu2

  • Western blot analyses of CS, PMS, and LMS in the liver subfractions showed that changes in protein levels of CS, LMS, and PMS were consistent with the corresponding changes in the respective mRNA levels [8].


  1. Sialidase of rat hepatomas: qualitative and quantitative comparison with rat liver sialidase. Miyagi, T., Goto, T., Tsuiki, S. Gann = Gan. (1984) [Pubmed]
  2. Purification and characterization of cytosolic sialidase from rat liver. Miyagi, T., Tsuiki, S. J. Biol. Chem. (1985) [Pubmed]
  3. Genetic analysis of liver neuraminidase isozymes in Rattus norvegicus: independent control of NEU-1 and NEU-2 phenotypes. Samollow, P.B., Vandeberg, J.L., Ford, A.L., Kunz, H.W., Gill, T.J. Genetics (1986) [Pubmed]
  4. An investigation of the activity of recombinant rat skeletal muscle cytosolic sialidase. Albouz-Abo, S., Turton, R., Wilson, J.C., von Itzstein, M. FEBS Lett. (2005) [Pubmed]
  5. Overexpression of cytosolic sialidase Neu2 induces myoblast differentiation in C2C12 cells. Fanzani, A., Giuliani, R., Colombo, F., Zizioli, D., Presta, M., Preti, A., Marchesini, S. FEBS Lett. (2003) [Pubmed]
  6. Rat-liver lysosomal sialidase. Solubilization, substrate specificity and comparison with the cytosolic sialidase. Miyagi, T., Tsuiki, S. Eur. J. Biochem. (1984) [Pubmed]
  7. Involvement of an endogenous sialidase in skeletal muscle cell differentiation. Sato, K., Miyagi, T. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  8. Chronic ethanol consumption upregulates the cytosolic and plasma membrane sialidase genes, but down regulates lysosomal membrane sialidase gene in rat liver. Garige, M., Azuine, M.A., Lakshman, M.R. Metab. Clin. Exp. (2006) [Pubmed]
  9. Cytosolic sialidase Neu2 upregulation during PC12 cells differentiation. Fanzani, A., Colombo, F., Giuliani, R., Preti, A., Marchesini, S. FEBS Lett. (2004) [Pubmed]
  10. Genomic organization and the 5'-upstream sequence of the rat cytosolic sialidase gene. Sato, K., Miyagi, T. Glycobiology (1995) [Pubmed]
  11. Immunohistochemical localization of cytosolic sialidase in photoreceptor cells. Uehara, F., Ohba, N., Sameshima, M., Yanagita, T., Iwakiri, N., Ozawa, M., Miyagi, T. Jpn. J. Ophthalmol. (1996) [Pubmed]
  12. Deleterious actions of chronic ethanol treatment on the glycosylation of rat brain clusterin. Hale, E.A., Raza, S.K., Ciecierski, R.G., Ghosh, P. Brain Res. (1998) [Pubmed]
  13. Differential effect of various inhibitors on four types of rat sialidase. Miyagi, T., Hata, K., Hasegawa, A., Aoyagi, T. Glycoconj. J. (1993) [Pubmed]
  14. Chronic ethanol feeding controls the activities of various sialidases by regulating their relative synthetic rates in the rat liver. Azuine, M.A., Patel, S.J., Lakshman, M.R. Metab. Clin. Exp. (2005) [Pubmed]
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