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Gene Review

Bach2  -  BTB and CNC homology 2

Mus musculus

Synonyms: BTB and CNC homolog 2, E030004N02Rik, Transcription regulator protein BACH2
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Disease relevance of Bach2

  • The Bach2-enhanced green fluorescent protein bicistronic retrovirus was used to monitor the fate of Bach2-expressing cells at the single cell level [1].
  • Bach2 is involved in neuronal differentiation of N1E-115 neuroblastoma cells [2].

High impact information on Bach2

  • Bach2 is a B-cell- and neuron-specific transcription repressor that forms heterodimers with the Maf-related oncoproteins [3].
  • In transfection assays using fibroblast cells, the fgf4 gene was upregulated in the presence of both MAZR and Bach2 in a BTB/POZ domain-dependent manner [3].
  • A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain [3].
  • MAZR forms homo- and hetero-oligomers with Bach2 through the BTB domain, which oligomers bind to guanine-rich sequences [3].
  • Bach1 and Bach2 function as transcription repressors in transfection assays using fibroblast cells, but they function as a transcriptional activator and repressor, respectively, in cultured erythroid cells [4].

Biological context of Bach2


Anatomical context of Bach2

  • Consistent with the fact that subcellular localization of Bach2 is regulated by nuclear export in cultured cells, extensive Bach2-staining was found in the cytoplasmic regions of developing neuronal and lens cells [5].
  • Little is known about the direct target genes of Bach2 in B cells [6].
  • Therefore, the Prdm1 regulation in B cells involves the repression by Bach2, which may be cancelled upon terminal plasma cell differentiation [6].

Associations of Bach2 with chemical compounds


Physical interactions of Bach2


Regulatory relationships of Bach2

  • These results suggest that Bach2 regulates AP-1- and Maf-dependent gene expression during development of neuronal and lens cells and that its activity may be regulated by nuclear export in these cells [5].

Other interactions of Bach2


Analytical, diagnostic and therapeutic context of Bach2

  • The largest average increase was observed for the transcription factor Bach2, and this increase was confirmed by RT-PCR [7].


  1. Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies. Muto, A., Tashiro, S., Tsuchiya, H., Kume, A., Kanno, M., Ito, E., Yamamoto, M., Igarashi, K. J. Biol. Chem. (2002) [Pubmed]
  2. Bach2 is involved in neuronal differentiation of N1E-115 neuroblastoma cells. Shim, K.S., Rosner, M., Freilinger, A., Lubec, G., Hengstschläger, M. Exp. Cell Res. (2006) [Pubmed]
  3. A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. Kobayashi, A., Yamagiwa, H., Hoshino, H., Muto, A., Sato, K., Morita, M., Hayashi, N., Yamamoto, M., Igarashi, K. Mol. Cell. Biol. (2000) [Pubmed]
  4. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Oyake, T., Itoh, K., Motohashi, H., Hayashi, N., Hoshino, H., Nishizawa, M., Yamamoto, M., Igarashi, K. Mol. Cell. Biol. (1996) [Pubmed]
  5. Expression of the oxidative stress-regulated transcription factor bach2 in differentiating neuronal cells. Hoshino, H., Igarashi, K. J. Biochem. (2002) [Pubmed]
  6. Plasmacytic transcription factor blimp-1 is repressed by bach2 in B cells. Ochiai, K., Katoh, Y., Ikura, T., Hoshikawa, Y., Noda, T., Karasuyama, H., Tashiro, S., Muto, A., Igarashi, K. J. Biol. Chem. (2006) [Pubmed]
  7. Microarray analysis of altered gene expression in the TM4 Sertoli-like cell line exposed to chromium(III) chloride. Cheng, R.Y., Alvord, W.G., Powell, D., Kasprzak, K.S., Anderson, L.M. Reprod. Toxicol. (2002) [Pubmed]
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