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Gene Review

Gdf2  -  growth differentiation factor 2

Mus musculus

Synonyms: BMP-9, Bmp9, Bone morphogenetic protein 9, GDF-2, Growth/differentiation factor 2
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High impact information on Gdf2


Biological context of Gdf2


Anatomical context of Gdf2


Other interactions of Gdf2

  • Radiographic and histological evaluation demonstrated that BMP-6 and BMP-9 induced the most robust and mature ossification at multiple time points [4].
  • However, cross-competition experiments demonstrate that the BMP-9 receptors on HepG2 cells do not bind other BMPs or TGF-beta s, indicating that these are novel receptors with binding specificity for BMP-9 [7].
  • In the presence of neutralizing antibodies (Ab) against TGF-beta1, BMP-9 concentrations of 3 ng or higher synergized with IL-3, SF+IL-3, SF+IL-11/12, or IL-3+SF+IL-11/12 to increase CFU-C generation [8].

Analytical, diagnostic and therapeutic context of Gdf2

  • To determine whether the genes induced by BMP9 in culture were constituents of the BFCN transcriptome, we purified BFCN from embryonic day 18 mouse septum by using fluorescence-activated cell sorting of NGFR(+) cells and profiled mRNA expression of these and NGFR(-) cells [2].


  1. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Truksa, J., Peng, H., Lee, P., Beutler, E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Lopez-Coviella, I., Follettie, M.T., Mellott, T.J., Kovacheva, V.P., Slack, B.E., Diesl, V., Berse, B., Thies, R.S., Blusztajn, J.K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. Peng, Y., Kang, Q., Luo, Q., Jiang, W., Si, W., Liu, B.A., Luu, H.H., Park, J.K., Li, X., Luo, J., Montag, A.G., Haydon, R.C., He, T.C. J. Biol. Chem. (2004) [Pubmed]
  4. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Kang, Q., Sun, M.H., Cheng, H., Peng, Y., Montag, A.G., Deyrup, A.T., Jiang, W., Luu, H.H., Luo, J., Szatkowski, J.P., Vanichakarn, P., Park, J.Y., Li, Y., Haydon, R.C., He, T.C. Gene Ther. (2004) [Pubmed]
  5. Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain. Lopez-Coviella, I., Mellott, T.M., Kovacheva, V.P., Berse, B., Slack, B.E., Zemelko, V., Schnitzler, A., Blusztajn, J.K. Brain Res. (2006) [Pubmed]
  6. Upregulation of acetylcholine synthesis by bone morphogenetic protein 9 in a murine septal cell line. López-Coviella, I., Berse, B., Thies, R.S., Blusztajn, J.K. J. Physiol. Paris (2002) [Pubmed]
  7. Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation. Song, J.J., Celeste, A.J., Kong, F.M., Jirtle, R.L., Rosen, V., Thies, R.S. Endocrinology (1995) [Pubmed]
  8. Bone morphogenetic protein 9 is a potent synergistic factor for murine hemopoietic progenitor cell generation and colony formation in serum-free cultures. Ploemacher, R.E., Engels, L.J., Mayer, A.E., Thies, S., Neben, S. Leukemia (1999) [Pubmed]
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