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Gene Review

Bmp6  -  bone morphogenetic protein 6

Mus musculus

Synonyms: BMP-6, Bmp-6, Bone morphogenetic protein 6, D13Wsu115e, VG-1-related protein, ...
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Disease relevance of Bmp6


High impact information on Bmp6


Biological context of Bmp6


Anatomical context of Bmp6


Associations of Bmp6 with chemical compounds


Regulatory relationships of Bmp6

  • Double immunolabeling studies revealed that only approximately 10% of BMP-6-positive bone marrow cells co-expressed the osteoblast transcription factor Cbfa1 suggesting that they are largely distinct from the osteoblast precursor population generated concurrently [10].
  • Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation [12].

Other interactions of Bmp6

  • We thus concluded that endogenous BMP2 and BMP6 cooperatively play pivotal roles in bone formation under both physiological and pathological conditions [1].
  • Although bmp6 was expressed, ihh transcripts were not found in primordia of intramembranous bones, nor in cells lining the future articular surfaces [2].
  • Based on knockout mouse models BMP-6 does not play an essential role in ovarian function, but GDF-9 is absolutely required for preantral follicle development [13].
  • Radiographic and histological evaluation demonstrated that BMP-6 and BMP-9 induced the most robust and mature ossification at multiple time points [6].
  • In contrast, misexpression of BMP-6 resulted in complete agenesis of the pancreas and reduced the size of the stomach and spleen dramatically and caused fusion of the liver and duodenum [14].

Analytical, diagnostic and therapeutic context of Bmp6


  1. Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation. Kugimiya, F., Kawaguchi, H., Kamekura, S., Chikuda, H., Ohba, S., Yano, F., Ogata, N., Katagiri, T., Harada, Y., Azuma, Y., Nakamura, K., Chung, U.I. J. Biol. Chem. (2005) [Pubmed]
  2. Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis. Iwasaki, M., Le, A.X., Helms, J.A. Mech. Dev. (1997) [Pubmed]
  3. Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Lyons, K.M., Pelton, R.W., Hogan, B.L. Genes Dev. (1989) [Pubmed]
  4. Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions. Blessing, M., Schirmacher, P., Kaiser, S. J. Cell Biol. (1996) [Pubmed]
  5. Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart. Kim, R.Y., Robertson, E.J., Solloway, M.J. Dev. Biol. (2001) [Pubmed]
  6. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Kang, Q., Sun, M.H., Cheng, H., Peng, Y., Montag, A.G., Deyrup, A.T., Jiang, W., Luu, H.H., Luo, J., Szatkowski, J.P., Vanichakarn, P., Park, J.Y., Li, Y., Haydon, R.C., He, T.C. Gene Ther. (2004) [Pubmed]
  7. Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Jones, C.M., Lyons, K.M., Hogan, B.L. Development (1991) [Pubmed]
  8. A novel role for bone morphogenetic proteins in the synthesis of follicle-stimulating hormone. Huang, H.J., Wu, J.C., Su, P., Zhirnov, O., Miller, W.L. Endocrinology (2001) [Pubmed]
  9. Mice lacking Bmp6 function. Solloway, M.J., Dudley, A.T., Bikoff, E.K., Lyons, K.M., Hogan, B.L., Robertson, E.J. Dev. Genet. (1998) [Pubmed]
  10. Increased bone morphogenetic protein-6 expression in mouse long bones after estrogen administration. Plant, A., Tobias, J.H. J. Bone Miner. Res. (2002) [Pubmed]
  11. Attenuation of osteoclastogenesis and osteoclast function by apigenin. Bandyopadhyay, S., Lion, J.M., Mentaverri, R., Ricupero, D.A., Kamel, S., Romero, J.R., Chattopadhyay, N. Biochem. Pharmacol. (2006) [Pubmed]
  12. Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation. D'Souza, S.J., Pajak, A., Balazsi, K., Dagnino, L. J. Biol. Chem. (2001) [Pubmed]
  13. Oocyte-expressed TGF-beta superfamily members in female fertility. Elvin, J.A., Yan, C., Matzuk, M.M. Mol. Cell. Endocrinol. (2000) [Pubmed]
  14. Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dichmann, D.S., Miller, C.P., Jensen, J., Scott Heller, R., Serup, P. Dev. Dyn. (2003) [Pubmed]
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