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Gene Review

umuC  -  DNA polymerase V subunit UmuC

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of umuC

  • Several flavones inhibited the in vitro activation of aflatoxin B1 in a system employing umuC gene activation due to DNA damage in Salmonella typhimurium TA1535/pSK1002, with naringenin being as effective as any [1].
  • These results show that while technical toxaphene is a weak, direct-acting mutagen in some bacterial tests, a dose-dependent toxicity and genotoxicity of its photoproducts could be conclusively demonstrated by the umuC test [2].
 

High impact information on umuC

 

Chemical compound and disease context of umuC

 

Biological context of umuC

 

Anatomical context of umuC

  • All-trans beta-carotene enhances mitogenic responses and ornithine decarboxylase activity of BALB/c 3T3 fibroblast cells induced by tumor promoter and fetal bovine serum but suppresses mutagen-dependent umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) [7].
  • Furthermore, when DEHP was treated with highly purified lipase from porcine pancreas, a significant umu C gene expression was observed and this expression was enhanced in the presence of 1 or 5 mM bile acids such as choric acid and deoxychoric acid [8].
 

Associations of umuC with chemical compounds

References

  1. In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. Guengerich, F.P., Kim, D.H. Carcinogenesis (1990) [Pubmed]
  2. Genotoxic activity of a technical toxaphene mixture and its photodegradation products in SOS genotoxicity tests. Bartos, T., Skarek, M., Cupr, P., Kosubová, P., Holoubek, I. Mutat. Res. (2005) [Pubmed]
  3. Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002. Oda, Y., Yamazaki, H., Shimada, T. Carcinogenesis (1999) [Pubmed]
  4. Reduction and mutagenic activation of nitroaromatic compounds by a Mycobacterium sp. Rafii, F., Selby, A.L., Newton, R.K., Cerniglia, C.E. Appl. Environ. Microbiol. (1994) [Pubmed]
  5. Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses. Baertschi, S.W., Raney, K.D., Shimada, T., Harris, T.M., Guengerich, F.P. Chem. Res. Toxicol. (1989) [Pubmed]
  6. Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B(1)-induced genotoxicities. Ueng, Y.F., Shyu, C.C., Liu, T.Y., Oda, Y., Lin, Y.L., Liao, J.F., Chen, C.F. Biochem. Pharmacol. (2001) [Pubmed]
  7. All-trans beta-carotene enhances mitogenic responses and ornithine decarboxylase activity of BALB/c 3T3 fibroblast cells induced by tumor promoter and fetal bovine serum but suppresses mutagen-dependent umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002). Okai, Y., Higashi-Okai, K., Yano, Y., Otani, S. Cancer Lett. (1996) [Pubmed]
  8. Enhancing effect of a plastic plasticizer, di-2-ethylhexyl phthalate on umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002). Okai, Y., Higashi-Okai, K. J. UOEH (2000) [Pubmed]
  9. Induction of umuC gene expression by nitrogen dioxide in Salmonella typhimurium. Kosaka, H., Oda, Y., Uozumi, M. Mutat. Res. (1985) [Pubmed]
  10. A microplate version of the SOS/umu-test for rapid detection of genotoxins and genotoxic potentials of environmental samples. Reifferscheid, G., Heil, J., Oda, Y., Zahn, R.K. Mutat. Res. (1991) [Pubmed]
  11. In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenase in mouse liver. Ueng, Y.F., Chang, Y.L., Oda, Y., Park, S.S., Liao, J.F., Lin, M.F., Chen, C.F. Life Sci. (1999) [Pubmed]
  12. Use of a high-throughput umu-microplate test system for rapid detection of genotoxicity produced by mutagenic carcinogens and airborne particulate matter. Oda, Y., Funasaka, K., Kitano, M., Nakama, A., Yoshikura, T. Environ. Mol. Mutagen. (2004) [Pubmed]
  13. Analysis of the involvement of human N-acetyltransferase 1 in the genotoxic activation of bladder carcinogenic arylamines using a SOS/umu assay system. Oda, Y. Mutat. Res. (2004) [Pubmed]
 
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